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ICAM1

  • Official Full Name

    intercellular adhesion molecule 1

  • Overview

    This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008] ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family thatfunctions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is asingle-chain glycoprotein that can be expressed on non-hematopoietic cells ofmany lineages. The role of ICAM-1 as a disease marker has been demonstrated fora number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for therecruitment of activated leukocytes and the pathogenesis of allergic rhinitis.In lymphoproliferative disorders, ICAM-1 is related to the degree ofmalignancy.
  • Synonyms

    ICAM1; intercellular adhesion molecule 1; BB2; CD54; P3.58; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; ICAM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Dog
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Pig
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse
  • Yeast
  • C
  • hIgG
  • His
  • hFc
  • mFc
  • Fc
  • Fc Chimera
  • Avi
  • Fc|His
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • His|GST
  • His|T7
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ICAM1-2249H Active Recombinant Human ICAM1 protein, His-tagged HEK293 His Met 1-Glu 480
Human ICAM1-471H Active Recombinant Human ICAM1, Fc Chimera Mammalian cells Fc Chimera
Human ICAM1-89H Active Recombinant Human ICAM1 Mammalian cells N/A
Human ICAM1-101H Active Recombinant Human ICAM1, HIgG1 Fc-tagged CHO Fc
Human ICAM1-146H Active Recombinant Human ICAM1, Fc-tagged CHO Fc
Human ICAM1-102H Active Recombinant Human ICAM1, HIgG1 Fc-tagged, mutant CHO Fc
Human ICAM1 Active Recombinant Human ICAM1 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Gln28-Glu480
Human ICAM1-28631TH Recombinant Human ICAM1, His-tagged E.coli His
Human ICAM1-2777H Recombinant Human ICAM1 protein, GST-tagged E.coli GST Asn26~Glu480 (Accession # P05362)
Human ICAM1-1625H Recombinant Human Intercellular Adhesion Molecule 1, Fc Chimera Mammalian cells Fc
Human ICAM1-22H Recombinant Human ICAM1 Protein, Fc-His-tagged Insect Cell Fc/His
Human ICAM1-657H Recombinant Human ICAM1 protein(Met1-Glu480) HEK293 N/A Met1-Glu480
Human ICAM1-946H Recombinant Human Intercellular Adhesion Molecule 1 CHO N/A
Human ICAM1-655H Recombinant Human ICAM1 protein, Fc-tagged HEK293 human/IgG1/Fc 453
Human ICAM1-28924TH Recombinant Human ICAM1 E.coli N/A
Human ICAM1-278H Recombinant Human Intercellular Adhesion Molecule-1, His-tagged E.coli His
Human ICAM1-656H Recombinant Human ICAM1, Fc-His tagged Human Cell Fc/His
Human ICAM1-28590TH Recombinant Human ICAM1 CHO N/A
Human ICAM1-2655HCL Recombinant Human ICAM1 cell lysate Human Cell N/A
Human ICAM1-1179HFL Recombinant Full Length Human ICAM1 Protein, C-Flag-tagged Mammalian cells Flag
Human ICAM1-799H Recombinant Human ICAM1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ICAM1-2365H Recombinant Human ICAM1 Protein (Met1-Glu480), C-His tagged Mammalian cells C-His Met1-Glu480
Human CAB11556MH Mouse Anti-Human Inter-Cellular Adhesion Molecule 1 Monoclonal Antibody Mouse N/A
Human ICAM1-292H Recombinant Human ICAM1 Protein, Fc-tagged HEK293 Fc 532
Human ICAM1-151H Recombinant Human ICAM1 Protein, His-tagged Human Cells His
Human ICAM1-14H Active Recombinant Human ICAM1 Protein (28-480aa), C-hIgG-His-tagged Insect Cell C-hIgG-His 28-480 aa
Human ICAM1-88H-B Recombinant Human ICAM1 Protein Pre-coupled Magnetic Beads HEK293
Human ICAM1-88H Recombinant Human ICAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ICAM1-5234H Recombinant Human ICAM1 protein, GST-tagged E.coli GST 28-480aa
Human ICAM1-540H Recombinant Human ICAM1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ICAM1-0235H Active Recombinant Human ICAM1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln28-Glu480
Human ICAM1-1202H Recombinant Human ICAM1 Protein (Gln28-Glu480), N-His tagged E.coli N-His Gln28-Glu480
Human ICAM1-0237H Active Recombinant Human ICAM1 protein, Fc-tagged HEK293 Fc Gln28-Glu480
Human ICAM1-627H Recombinant Human ICAM1 Protein (Gln48-Glu480), C-mFc-tagged HEK293 C-mFc Gln48-Glu480
Human ICAM1-2364H Recombinant Human ICAM1 Protein (Gln28-Glu480), C-His tagged Mammalian cells C-His Gln28-Glu480
Mouse ICAM1-316M Active Recombinant Mouse ICAM1, MIgG2a Fc-tagged CHO Fc
Mouse ICAM1-317M Active Recombinant Mouse ICAM1, MIgG2a Fc-tagged, mutant CHO Fc
Mouse Icam1-5640M Active Recombinant Mouse Intercellular Adhesion Molecule 1, Fc-tagged Mammalian cells Fc
Mouse Icam1-2778M Recombinant Mouse Icam1 protein, His-tagged E.coli His Val46~Leu301 (Accession # P13597)
Mouse Icam1-2779M Recombinant Mouse Icam1 protein, His-tagged E.coli His Ser328~Ser465 (Accession # P13597)
Mouse ICAM1-23M Recombinant Mouse Icam1 Protein, His-tagged Insect Cell His 28-485aa
Mouse Icam1-3323M Active Recombinant Mouse Icam1 protein(Met1-Asn485), His&hFc-tagged HEK293 C-His&hFc Met1-Asn485
Mouse Icam1-2293M Active Recombinant Mouse Icam1 protein(Met1-Asn485), His-tagged HEK293 C-His Met1-Asn485
Mouse ICAM1-2487MCL Recombinant Mouse ICAM1 cell lysate Human Cell N/A
Mouse Icam1-1204M Recombinant Mouse Icam1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ICAM1-0236M Recombinant Mouse ICAM1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gln28-Asn485
Mouse Icam1-58M Recombinant Mouse Icam1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Icam1-58M-B Recombinant Mouse Icam1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Icam1-4322M Recombinant Mouse Icam1 Protein Yeast N/A 458aa
Rat Icam1-2781R Recombinant Rat Icam1 protein, His & T7-tagged E.coli His/T7 Ser102~Arg306 (Accession # Q00238)
Rat Icam1-1793R Recombinant Rat Intercellular Adhesion Molecule 1 Mammalian cells N/A
Rat Icam1-4086R Recombinant Rat Icam1, His tagged Human Cell His
Rat Icam1-1067R Recombinant Rat Icam1 Protein, Fc-tagged HEK293 Fc
Rat ICAM1-2979R Recombinant Rat ICAM1 Protein Mammalian Cell His
Rat ICAM1-1970RCL Recombinant Rat ICAM1 cell lysate Human Cell N/A
Rat Icam1-6383R Recombinant Rat Icam1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Icam1-6383R-B Recombinant Rat Icam1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus monkey ICAM1-1795R Recombinant Rhesus Monkey ICAM1 Protein HEK293 N/A
Rhesus monkey ICAM1-1797R Recombinant Rhesus Monkey ICAM1 Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey ICAM1-1796R Recombinant Rhesus Monkey ICAM1 Protein, hIgG1-tagged HEK293 hIgG1
Rabbit ICAM1-2266R Recombinant Rabbit ICAM1 Protein, His&SUMO-tagged E.coli N-His&SUMO Ser43-Asn295
Dog ICAM1-2776D Recombinant Dog ICAM1 protein, His & GST-tagged E.coli His/GST Gly25~Pro531 (Accession # F1PB95)
Bovine ICAM1-4320B Recombinant Bovine ICAM1 Protein Yeast N/A 453aa
Canis lupus familiaris (Dog) (Canis familiaris) RFL19727CF Recombinant Full Length Dog Intercellular Adhesion Molecule 1(Icam1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-528)
Homo sapiens (Human) RFL22358HF Recombinant Full Length Human Intercellular Adhesion Molecule 1(Icam1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-532)
Mus musculus (Mouse) RFL31469MF Recombinant Full Length Mouse Intercellular Adhesion Molecule 1(Icam1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-537)
Rattus norvegicus (Rat) RFL28346RF Recombinant Full Length Rat Intercellular Adhesion Molecule 1(Icam1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-545)
Rhesus ICAM1-1005R Recombinant Rhesus ICAM1 Protein (Met1-Glu480), His-tagged HEK293 His Met1-Glu480
Rhesus Macaque ICAM1-2184R Recombinant Rhesus monkey ICAM1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ICAM1-2005R Recombinant Rhesus Macaque ICAM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ICAM1-2005R-B Recombinant Rhesus Macaque ICAM1 Protein Pre-coupled Magnetic Beads HEK293
Pig ICAM1-2780P Recombinant Pig ICAM1 protein, His & T7-tagged E.coli His/T7 Gly27~Ala209 (Accession # Q9MZU5)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ICAM1 Related Articles

ICAM1 involved in several pathways and played different roles in them. We selected most pathways ICAM1 participated on our site, such as NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with ICAM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
NF-kappa B signaling pathwayMAP3K14;IRAK1;BCL2A1A;LRDD;IKBKG;DDX58;PIAS4;NFKBIA;GM1987
Cell adhesion molecules (CAMs)HLA-B;NRCAM;ITGB2L;VCAM1;SELPLG;NRXN3;ICAM2;CLDN11B;CDH2
Natural killer cell mediated cytotoxicityPLCG1;MICA;KIR3DL2;NCR3;FCGR3;TNFRSF10B;TNFRSF10A;IFNB1;FCGR3B
TNF signaling pathwayMAPK10;NFKB1;CASP10;MMP9;FAS;PGAM5;MAP3K5;CASP8;CFLAR
Leukocyte transendothelial migrationMYL5;MAPK13;ITGB2;CLDN16;PTPN11;RAP1A;MAPK12;VASP;MYL12A
African trypanosomiasisF2RL1;FAS;HPR;PRKCB;IDO2;GNAQ;LAMA4;Fasl;HBA2
MalariaIL-8;KLRK1;COMP;GYPB;MET;CD40;TLR9;GYPA;THBS1
Staphylococcus aureus infectionPTAFR;HLA-DRB1;ITGAM;FCGR1;HLA-DRB4;HLA-DRB3;H2-AB1;DSG1A;FCAR
Influenza ABMA2;GSK3B;PRKCB;MAVS;IFNA7;IFNB;TBK1;IFNA12;MAPK9
HTLV-I infectionANAPC2;VCAM1;CRTC2;ELK1;PDGFB;TP53;TBPL1;WNT11;ICAM1
Epstein-Barr virus infectionMAPK10;HSPA1A;POLR3F;NCOR2;PSMD3;HLA-DQB1;AKT2;PIK3CG;RB1
Rheumatoid arthritisATP6V1E2;IL11;IFNG;IL17A;TEK;HLA-DQA2;TNFRSF11A;MMP1A;LTB
Viral myocarditisRAC1;H2-Q10;MYH7;CASP8;BID;CD40;ITGAL;Casp3;HLA-DRB4

ICAM1 has several biochemical functions, for example, integrin binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ICAM1 itself. We selected most functions ICAM1 had, and list some proteins which have the same functions with ICAM1. You can find most of the proteins on our site.

Function Related Protein
integrin bindingADAM2;CYR61;ADAMTS13;ADAM15;ITGB1;LYN;VWF;FERMT3;ADAM25
protein bindingCDK2AP1;RRAGD;NEDD4L;RNF2;ATP7B;MRPS9;KIF9;ARMC1;TMEM115
receptor activityCD7;TNFRSF9;VPREB1;ITGB4;RAMP3;LILRB3;NR2C2;DARC;KRT1
transmembrane signaling receptor activityEDAR;TNFRSF10C;NCR2;SELE;TNFRSF8;OR4D6;OR4C13;HIST2H3C2;FZD7A
virus receptor activitySLAMF1;CLEC4G;SERPINB3;HSPA1B;ITGB7;TNFRSF14;SELPLG;LAMP1;CD209A

ICAM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ICAM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ICAM1.

ITGAL; FGG; UBC; Tubb4b; HSD3B7; EGFR; cona_canen

Cai, TT; Muhali, FS; et al. Genome-wide DNA methylation analysis in Graves' disease. GENOMICS 105:204-210(2015).
Meliton, AY; Meng, FY; et al. Oxidized phospholipids protect against lung injury and endothelial barrier dysfunction caused by heat-inactivated Staphylococcus aureus. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 308:L550-L562(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can ICAM1 be a potential therapeutic target? 07/11/2021

Yes, targeting ICAM1 is being explored as a potential therapeutic strategy for inflammatory diseases, with research focusing on developing ICAM1 inhibitors.

How is ICAM1 involved in inflammation? 07/09/2020

ICAM1 is upregulated during inflammation, promoting the adhesion of immune cells to the endothelium and facilitating their migration into inflamed tissues.

How is ICAM1 involved in cancer progression? 07/07/2019

ICAM1 expression can be altered in cancer cells and is implicated in promoting cancer progression by facilitating tumor cell adhesion, invasion, and metastasis.

Are there diagnostic applications for ICAM1 in clinical settings? 01/13/2017

ICAM1 levels can be measured in blood or tissue samples, and elevated levels may serve as diagnostic markers for certain inflammatory diseases.

Can ICAM1 be used as a prognostic marker in certain diseases? 08/13/2016

Elevated levels of ICAM1 in some diseases may serve as prognostic markers, indicating disease severity and potential outcomes.

Customer Reviews (3)

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Reviews
04/27/2022

    Manufacturers may provide documentation of the protein's validation, which includes information about its purity, concentration, stability, and potential contaminants.

    11/05/2020

      This can be particularly important in clinical trials to ensure accurate and reliable results.

      10/14/2016

        If the need arises for larger quantities of ICAM1 protein during the later stages of clinical trials, the manufacturer can facilitate scale-up production processes to meet those requirements.

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