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Official Full Name indoleamine 2,3-dioxygenase 1
Background Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in thesuppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
Synonyms IDO1; indoleamine 2,3-dioxygenase 1; IDO, INDO, indoleamine pyrrole 2,3 dioxygenase; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO; IDO-1
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IDO1-085H Recombinant Human IDO1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Ido1-1213M Recombinant Mouse Ido1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human IDO1-1419H Recombinant Human IDO1 Protein (1-403 aa), His-tagged Yeast His
    Mouse IDO1-2077M Recombinant Mouse IDO1 Protein (1-407 aa), His-tagged Yeast His
    Human IDO1-14054H Recombinant Human IDO1, GST-tagged E.coli GST
    Human IDO1-28269TH Recombinant Human IDO1 Wheat Germ N/A
    Human IDO1-294H Recombinant Human IDO1, His-tagged E.coli His
    Human IDO1-3829H Recombinant Human IDO1 protein, GST-tagged Insect Cell N/A
    Human IDO1-3920H Recombinant Human IDO1, His tagged E.coli His
    Human IDO1-5300HCL Recombinant Human IDO1 293 Cell Lysate HEK293 N/A
    Human IDO1-7190H Recombinant Human IDO1, His-tagged E.coli N/A
    Human IDO1-7325H Recombinant Human IDO1, None tagged E.coli N/A
    Mouse Ido1-2126M Recombinant Mouse Indoleamine 2,3-dioxygenase 1, His-tagged E.coli His
    Mouse Ido1-7432M Recombinant Mouse Ido1 Protein, His-tagged E.coli His
    Mouse IDO1-7992M Recombinant Mouse IDO1 Protein Mammalian Cell His
    Rat IDO1-2990R Recombinant Rat IDO1 Protein Mammalian Cell His
    Rat Ido1-36R Recombinant Rat Ido1 Protein, His-tagged E.coli His
    Zebrafish IDO1-5465Z Recombinant Zebrafish IDO1 Mammalian Cell His
    Kit-1754 Human IDO1 Cell-Based Assay Kit N/A
    Kit-1755 Human IDO1 Fluorogenic Inhibitor Screening Assay Kit N/A
    Kit-1756 Human IDO1 Fluorogenic Inhibitor Screening Assay Kit (384) N/A
    Kit-1757 Human IDO1 Inhibitor Screening Assay Kit N/A
    Kit-1758 Human IDO1 Inhibitor Screening Assay Kit (384) N/A
    Kit-1763 IDO1 Inhibitor Mechanism of Action Assay Kit N/A
    Kit-1782 Mouse IDO1 Inhibitor Screening Assay Kit N/A
    Kit-2211 Indoleamine 2,3-Dioxygenase 1 Activity Assay Kit N/A
    Kit-2388 Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Screening Kit N/A

    IDO1 involved in several pathways and played different roles in them. We selected most pathways IDO1 participated on our site, such as Tryptophan metabolism, Metabolic pathways, African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Tryptophan metabolism HADHA; ACAT2; INMT; ALDH2.1; GCDH; TDO2B; MAOB; AOX4; AOC1; TPH1B
    Metabolic pathways HSD17B12A; CYP3A41B; ACOT5; ACADS; LIPG; NDUFA2; ATP5L; CERS4; FUT8A; UCKL1
    African trypanosomiasis PLCB4; PLCB3; PRKCG; HBA1; HBA-A2; TNF; FAS; PRKCB; IL12B; IL18

    IDO1 has several biochemical functions, for example, electron carrier activity, heme binding, indoleamine 2,3-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDO1 itself. We selected most functions IDO1 had, and list some proteins which have the same functions with IDO1. You can find most of the proteins on our site.

    Function Related Protein
    electron carrier activity SH3BGRL3; IDH3B; PTGES2; AKR1A1; GRXCR1; ALDH2; NDUFV2; GCDHA; DERL3; HAAO
    heme binding NENF; CYP2AD2; CYP7A1; CYP2D10; HEBP1; HBE1; CYP2AA1; CYP3A7; HBB-Y; CYP3A5
    indoleamine 2,3-dioxygenase activity IDO2; IDO1
    metal ion binding HEPHL1A; ZEB2B; ZNF548; ZKSCAN1; NAALADL1; REST; CXXC1B; ZNF428; POLR3B; EXT2
    tryptophan 2,3-dioxygenase activity TDO2B; TDO2A; IDO2; TDO2; IDO1

    IDO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDO1.

    q8d0v8_yerpe; PPP1R16A; DDX24; TERF2IP

    Theate, I; van Baren, N; et al. Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues. CANCER IMMUNOLOGY RESEARCH 3:161-172(2015).
    Kang, W; Marasco, WA; et al. Anti-tat Hutat2:Fc mediated protection against tat-induced neurotoxicity and HIV-1 replication in human monocyte-derived macrophages. JOURNAL OF NEUROINFLAMMATION 11:-(2014).

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