ido1
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  • Official Full Name
  • indoleamine 2,3-dioxygenase 1
  • Background
  • Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in thesuppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.
  • Synonyms
  • IDO1; indoleamine 2,3-dioxygenase 1; IDO, INDO, indoleamine pyrrole 2,3 dioxygenase; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO; IDO-1
Cat.#:IDO1-3829HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human IDO1 protein, GST-tagged
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Cat.#:Ido1-2126MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Indoleamine 2,3-dioxygenase 1, His-tagged
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Cat.#:IDO1-14054HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDO1, GST-tagged
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Cat.#:IDO1-28269THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IDO1
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Cat.#:IDO1-294HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDO1, His-tagged
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Cat.#:IDO1-3920HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDO1, His tagged
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Cat.#:IDO1-7190HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDO1, His-tagged
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Cat.#:IDO1-7325HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IDO1, None tagged
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Cat.#:Ido1-7432MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ido1 Protein, His-tagged
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Cat.#:IDO1-7992MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse IDO1 Protein
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Cat.#:IDO1-2990RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IDO1 Protein
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Cat.#:Ido1-36RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ido1 Protein, His-tagged
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Cat.#:IDO1-5465ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IDO1
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Cat.#:IDO1-5300HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IDO1 293 Cell Lysate
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Cat.#:Kit-1754Tag:
Source (Host):Species:
Product nameHuman IDO1 Cell-Based Assay Kit
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Cat.#:Kit-1755Tag:
Source (Host):Species:
Product nameHuman IDO1 Fluorogenic Inhibitor Screening Assay Kit
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Cat.#:Kit-1756Tag:
Source (Host):Species:
Product nameHuman IDO1 Fluorogenic Inhibitor Screening Assay Kit (384)
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Cat.#:Kit-1757Tag:
Source (Host):Species:
Product nameHuman IDO1 Inhibitor Screening Assay Kit
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Cat.#:Kit-1758Tag:
Source (Host):Species:
Product nameHuman IDO1 Inhibitor Screening Assay Kit (384)
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Cat.#:Kit-1763Tag:
Source (Host):Species:
Product nameIDO1 Inhibitor Mechanism of Action Assay Kit
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Cat.#:Kit-1782Tag:
Source (Host):Species:
Product nameMouse IDO1 Inhibitor Screening Assay Kit
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Cat.#:Kit-2211Tag:
Source (Host):Species:
Product nameIndoleamine 2,3-Dioxygenase 1 Activity Assay Kit
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Cat.#:Kit-2388Tag:
Source (Host):Species:
Product nameIndoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Screening Kit
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Involved Pathway

IDO1 involved in several pathways and played different roles in them. We selected most pathways IDO1 participated on our site, such as Tryptophan metabolism, Metabolic pathways, African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tryptophan metabolism
ANI_1_2390104; TDO2B; KYNU; ACAT2; AADAT; AOX1; MAOB; CYP1A; OGDHL; AOX2P
Metabolic pathways
DAO.1; DOLK; ATP5D; PAFAH2; APRT; B3GNT5; MT-ND4; NDUFV3; CYP2C37; PLA2G2E
African trypanosomiasis
APOA1; APOL1; IDO1; PLCB1; GNAQ; PRKCB; FASLG; IL18; HBB-B2; IFNG

Protein Function

IDO1 has several biochemical functions, for example, electron carrier activity, heme binding, indoleamine 2,3-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDO1 itself. We selected most functions IDO1 had, and list some proteins which have the same functions with IDO1. You can find most of the proteins on our site.
Function
Related Protein
Function electron carrier activity
Related Protein ACAD8; AOX3L1; ME1; NDUFS2; PHGDH; GLRX2; FDX1; GPX2; HSD17B6; MAOB
Function heme binding
Related Protein CYP2C70; HBBE2; CYP2AA1; CYP1D1; HBA-X; IRGM1; CBS; FA2H; HBAA1; HRG
Function indoleamine 2,3-dioxygenase activity
Related Protein IDO1; IDO2
Function metal ion binding
Related Protein RHOV; ZNF397; VDRB; BAK1; KLF10; MB21D1; CYP4V7; ZXDC; ZNF669; ZFP639
Function tryptophan 2,3-dioxygenase activity
Related Protein TDO2B; IDO1; IDO2; TDO2A; TDO2

Interacting Protein

IDO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDO1.
q8d0v8_yerpe; PPP1R16A; DDX24; TERF2IP

IDO1 Related Articles

Theate, I; van Baren, N; et al. Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues. CANCER IMMUNOLOGY RESEARCH 3:161-172(2015).
Kang, W; Marasco, WA; et al. Anti-tat Hutat2:Fc mediated protection against tat-induced neurotoxicity and HIV-1 replication in human monocyte-derived macrophages. JOURNAL OF NEUROINFLAMMATION 11:-(2014).