|Official Full Name||indoleamine 2,3-dioxygenase 1|
|Background||Indoleamine 2,3-dioxygenase (IDO) is an enzyme that is responsible for converting tryptophan to kynurenines. IDO is expressed by a wide variety of tissues and IDO can be upregulated by interferon gamma. IDO modulates levels of the amino acid tryptophan, which is vital for cell growth, but is also involved in the suppression of the immune response. IDO may be involved in thesuppression of the immune response to tumours and blocking the IDO pathway may be a potential target for immunotherapy.|
|Synonyms||IDO1; indoleamine 2,3-dioxygenase 1; IDO, INDO, indoleamine pyrrole 2,3 dioxygenase; indole 2,3-dioxygenase; indolamine 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase; IDO; INDO; IDO-1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
IDO1 involved in several pathways and played different roles in them. We selected most pathways IDO1 participated on our site, such as Tryptophan metabolism, Metabolic pathways, African trypanosomiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with IDO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Tryptophan metabolism||HADHA; ACAT2; INMT; ALDH2.1; GCDH; TDO2B; MAOB; AOX4; AOC1; TPH1B|
|Metabolic pathways||HSD17B12A; CYP3A41B; ACOT5; ACADS; LIPG; NDUFA2; ATP5L; CERS4; FUT8A; UCKL1|
|African trypanosomiasis||PLCB4; PLCB3; PRKCG; HBA1; HBA-A2; TNF; FAS; PRKCB; IL12B; IL18|
IDO1 has several biochemical functions, for example, electron carrier activity, heme binding, indoleamine 2,3-dioxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IDO1 itself. We selected most functions IDO1 had, and list some proteins which have the same functions with IDO1. You can find most of the proteins on our site.
|electron carrier activity||SH3BGRL3; IDH3B; PTGES2; AKR1A1; GRXCR1; ALDH2; NDUFV2; GCDHA; DERL3; HAAO|
|heme binding||NENF; CYP2AD2; CYP7A1; CYP2D10; HEBP1; HBE1; CYP2AA1; CYP3A7; HBB-Y; CYP3A5|
|indoleamine 2,3-dioxygenase activity||IDO2; IDO1|
|metal ion binding||HEPHL1A; ZEB2B; ZNF548; ZKSCAN1; NAALADL1; REST; CXXC1B; ZNF428; POLR3B; EXT2|
|tryptophan 2,3-dioxygenase activity||TDO2B; TDO2A; IDO2; TDO2; IDO1|
IDO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IDO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IDO1.
q8d0v8_yerpe; PPP1R16A; DDX24; TERF2IP