ifngr1
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  • Official Full Name
  • IFNGR1 interferon gamma receptor 1
  • Background
  • It reacts with CD119, the alpha chain of the interferon gamma (IFN-gamma) receptor. This receptor is expressed by mouse leukocytes, endothelial, and epithelial cells, but not by mature erythrocytes. This antibody recognizes an epitope (susceptible to certain fixatives) in the ligand-binding site of the receptor. It can block the binding of mouse IFN-gamma; therefore, it can inhibit IFN-gamma mediated effects including the activation of mouse macrophages for tumor cell killing. IFN-gamma has been reported to induce the expression of Ly-6A/E antigen on cell lines and normal B lymphocytes, and the antibody is capable of inhibiting the IFN-gamma.induced expression of Ly-6A/E on the mouse B lymphoma line A20. The binding of the antibody to CD119 is inhibited by IFN-gamma. This antibody reportedly does not have any agonist effect.
  • Synonyms
  • IFNGR1; interferon gamma receptor 1; IFNGR; CD119; CDw119; AVP, type 2; IFN-gamma-R1; CD119 antigen; IFN-gamma receptor 1; antiviral protein, type 2; immune interferon receptor 1; interferon-gamma receptor alpha chain; FLJ45734;
Cat.#:IFNGR1-001HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human IFNGR1 Protein, His-tagged
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Cat.#:IFNGR1-381HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNGR1 Protein (Glu 18 - Gly 245), Fc-tagged
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Cat.#:IFNGR1-1186HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNGR1 Protein, MYC/DDK-tagged
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Cat.#:IFNGR1-22HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interferon Gamma Receptor 1, Fc Chimera
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Cat.#:IFNGR1-57HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Interferon Gamma Receptor 1
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Cat.#:IFNGR1-596Tag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Interferon Gamma Receptor 1
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Cat.#:Ifngr1-1748MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interferon Gamma Receptor 1, Fc-tagged
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Cat.#:IFNGR1-116HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNGR1 protein
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Cat.#:IFNGR1-143HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human IFNGR1
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Cat.#:IFNGR1-2250HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNGR1, His tagged
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Cat.#:IFNGR1-28503THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human IFNGR1, Fc-tagged
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Cat.#:IFNGR1-612HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNGR1, Fc-His tagged
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Cat.#:IFNGR1-7038HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IFNGR1 protein, His & T7-tagged
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Cat.#:Ifngr1-6953MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifngr1, Fc tagged
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Cat.#:Ifngr1-6954MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ifngr1, His tagged
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Cat.#:Ifngr1-7039MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ifngr1 protein, GST-tagged
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Cat.#:Ifngr1-8732RTag:N/A
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ifngr1, Fc tagged
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Cat.#:IFNGR1-105CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNGR1, His tagged
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Cat.#:IFNGR1-1207CTag:Fc
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNGR1 Protein, Fc-tagged
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Cat.#:IFNGR1-1550RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IFNGR1 Protein
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Cat.#:IFNGR1-1551RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IFNGR1 Protein, hIgG1-tagged
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Cat.#:IFNGR1-1552RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey IFNGR1 Protein, hIgG4-tagged
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Cat.#:IFNGR1-2208RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IFNGR1 Protein, His-tagged
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Cat.#:IFNGR1-3852CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IFNGR1
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Cat.#:IFNGR1-7671ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IFNGR1
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Cat.#:IFNGR1-2646HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IFNGR1 cell lysate
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Cat.#:IFNGR1-1775MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IFNGR1 cell lysate
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Cat.#:IFNGR1-1175RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IFNGR1 cell lysate
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Cat.#:IFNGR1-1003CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IFNGR1 cell lysate
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Involved Pathway

IFNGR1 involved in several pathways and played different roles in them. We selected most pathways IFNGR1 participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with IFNGR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
TNFRSF21; CCL7; IFNA6; PRL; TNFRSF25; IFNA5; CXCR3; TNFSF12; LIF; IFNA1
HIF- signaling pathway
SLC2A1; IFNG; PDHA1; IFNGR2; ANGPT1; PIK3R3; ERBB2; IFNGR1; ANGPT4; PFKFB3
Osteoclast differentiation
MAPK9; IL1R1; PPP3R2; IFNAR1; PIK3R3; PIK3R2; FCGR1A; MAPK8; BLNK; NCF1
Jak-STAT signaling pathway
LEPA; HRASB; CRLF2; IFNA10; IL11; NT5C3; IL6; IL7R; IL21R; IL4
Natural killer cell mediated cytotoxicity
SHC3; RAET1D; Raet1c; NFATC2; IFNA7; MAP2K1; KIR2DS2; GZMB; KIR2DL1; PIK3CD
Salmonella infection
ARPC5LA; WASF1; MAPK9; CASP1; WASL; IL8L2; MYD88; MAPK13; KLC2; CXCL3
Leishmaniasis
HLA-DPA1; IFNG; ELK1; NCF1; TGFB2; HLA-DMB; HLA-DRB3; TGFB1; IL12A; FCGR4
Chagas disease (American trypanosomiasis)
TLR9; PLCB4; MAPK11; IFNG; GNAL; IRAK1; MAPK12; TNFRSF1A; GNAS; FADD
Toxoplasmosis
TNF; HSPA8; HSPA1B; IRGM1; LAMA2; Casp3; HSPA6; MAPK11; MAP2K3; HLA-DOB
Tuberculosis
ATP6V0B; FCGR2B; ATP6V0A4; NFYB; ITGB2; CARD9; NFKB1; ATP6V0C; ATP6V0A1; TLR2
Measles
cgr2b; EIF3H; PIK3CG; IRF7; IFNAR2; IFNGR1; Fasl; IFNA14; IFIH1; IFNA13
Influenza A
NXF2; NUP98; HSPA6; EIF2AK2; SOCS3; TRIM25; IFNA1; RNASEL; RSAD2; MAP2K2
Herpes simplex infection
Ccl12; TBP; TRAF3; ALYREF; OAS2; NFKBIB; TLR9; EIF2AK1; SRSF5B; ABCB3L1
Inflammatory bowel disease (IBD)
IFNGR1; TLR2; IFNG; IL23R; RORA; TGFB3; IL17F; RORC; Il23a; IL1A

Protein Function

IFNGR1 has several biochemical functions, for example, cytokine binding, interferon-gamma receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IFNGR1 itself. We selected most functions IFNGR1 had, and list some proteins which have the same functions with IFNGR1. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine binding
Related Protein CSF1RA; TNFRSF11A; KITA; CD74; IFNGR1; IL31RA; NOG; CNTFR; Fzd4; IL17F
Function interferon-gamma receptor activity
Related Protein IFNGR2; IFNGR1
Function protein binding
Related Protein PRPF19; PRF1; FUBP3; RCOR3; TJP1; CD300LD; SP3; POP7; KIF3B; TPP2

Interacting Protein

IFNGR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IFNGR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IFNGR1.
STAT1; IFNG; c-fos promoter region; NFKB1; purL; fruB; Stat3

IFNGR1 Related Articles

Ciftdogan, DY; Onay, H; et al. IFNG and IFNGR1 gene polymorphisms in children with nonresponse to the hepatitis B vaccine. FUTURE VIROLOGY 9:123-130(2014).
Lee, SH; Carrero, JA; et al. Identifying the Initiating Events of Anti-Listeria Responses Using Mice with Conditional Loss of IFN-gamma Receptor Subunit 1 (IFNGR1). JOURNAL OF IMMUNOLOGY 191:4223-4234(2013).

IFNGR1 Related Gene Family

Cytokines