Recombinant Human Interferon Gamma Receptor 1
Cat.No. : | IFNGR1-57H |
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Cat. No. : | IFNGR1-57H |
Description : | IFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes. |
Source : | Mammalian cells |
Molecular Weight : | The predicted molecular weight of Recombinant Human IFN-γ R1 is Mr 25 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40-50 kDa. |
State Of Matter : | Lyophilized. |
Purity : | > 95% by SDS Page and analyzed by silver stain. |
Endotoxin : | < 1.0 EU/µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Tag : | Non |
Gene Name : | IFNGR1 interferon gamma receptor 1 [ Homo sapiens ] |
Synonyms : | IFNGR1; interferon gamma receptor 1; CD119; IFNGR; FLJ45734; AVP, type 2; CD119 antigen; immune interferon receptor 1; interferon-gamma receptor alpha chain; IFN-gamma-R1; OTTHUMP00000017285; interferon gamma receptor 1 |
Gene ID : | 3459 |
mRNA Refseq : | NM_000416 |
Protein Refseq : | NP_000407 |
UniProt ID : | P15260 |
Chromosome Location : | 6q23-q24 |
MIM : | 107470 |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity |
Function : | cytokine binding; interferon-gamma receptor activity; receptor activity |
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◆ Lysates | ||
IFNGR1-1775MCL | Recombinant Mouse IFNGR1 cell lysate | +Inquiry |
IFNGR1-1175RCL | Recombinant Rat IFNGR1 cell lysate | +Inquiry |
IFNGR1-1003CCL | Recombinant Cynomolgus IFNGR1 cell lysate | +Inquiry |
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Not For Human Consumption!
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