Recombinant Full Length Human IFNGR1 Protein, C-Flag-tagged

• Cat.No.: IFNGR1-1061HFL
• Product Overview: Recombinant Full Length Human IFNGR1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 52.5 kDa
• AA Sequence: MALLFLLPLVMQGVSRAEMGTADLG PSSVPTPTNVTIESYNMNPIVYWEY QIMPQVPVFTVEVKNYGVKN SEWIDACINISHHYCNISDHVGDPS NSLWVRVKARVGQKESAYAKSEEFA VCRDGKIGPPKLDIRKEEKQ IMIDIFHPSVFVNGDEQEVDYDPET TCYIRVYNVYVRMNGSEIQYKILTQ KEDDCDEIQCQLAIPVSSLN SQYCVSAEGVLHVWGVTTEKSKEVC ITIFNSSIKGSLWIPVVAALLLFLV LSLVFICFYIKKINPLKEKS IILPKSLISVVRSATLETKPESKYV SLITSYQPFSLEKEVVCEEPLSPAT VPGMHTEDNPGKVEHTEELS SITEVVTTEENIPDVVPGSHLTPIE RESSSPLSSNQSEPGSIALNSYHSR NCSESDHSRNGFDTDSSCLE SHSSLSDSEFPPNNKGEIKTEGQEL ITVIKAPTSFGYDKPHVLVDLLVDD SGKESLIGYRPTEDSKEFSTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity

Gene Information

• Gene Name: IFNGR1 interferon gamma receptor 1 [ Homo sapiens (human) ]
• Official Symbol: IFNGR1
• Synonyms: CD119; IFNGR; IMD27A; IMD27B
• Gene ID: 3459
• mRNA Refseq: NM_000416.3
• Protein Refseq: NP_000407.1
• MIM: 107470
• UniProt ID: P15260