| Description : |
IFNGR1, also known as interferon gamma receptor 1, is a member of the hematopoietic cytokine receptor superfamily. It is a receptor that binds interferon-γ, the sole member of interferon type II. It induces the rapid dimerization of chains, thereby forming a site that is recognized by the extracellular domain of IFNGR2. It is expressed in a membrane-bound form in many cell types, and is over-expressed in tumour cells. Its signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6. It is crucial for host defence against mycobacterial infections. It is associated with susceptibility to pulmonary tuberculosis (TB). |
| Source : |
Insect cell |
| Species : |
Human |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
26.6 kDa |
| AASequence : |
EMGTADLGPSSVPTPTNVTIESYNM NPIVYWEYQIMPQVPVFTVEVKNYG VKNSEWIDACINISHHYCNISDHVG DPSNSLWVRVKARVGQKESAYAKSE EFAVCRDGKIGPPKLDIRKEEKQIM IDIFHPSVFVNGDEQEVDYDPETTC YIRVYNVYVRMNGSEIQYKILTQKE DDCDEIQCQLAIPVSSLNSQYCVSA EGVLHVWGVTTEKSKEVCITIFNSS IKGHHHHHH |
| N-terminal Sequence Analysis : |
Glu 18 |
| Endotoxin : |
< 1.0 EU per 1 μg of protein (determined by LAL method) |
| Purity : |
> 90% by SDS - PAGE |
| Storage : |
Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles. |
| Concentration : |
1.0 mg/mL (determined by Absorbance at 280nm) |
| Storage Buffer : |
In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol. |
| Warning : |
For research use only. This product is not intended or approved for human, diagnostics or veterin |
