ITGA5
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Official Full Name
integrin alpha 5 (fibronectin receptor alpha)
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Overview
Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats. Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain. Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions. -
Synonyms
ITGA5; integrin alpha 5 (fibronectin receptor alpha); integrin alpha-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor alpha polypeptide; Fnra; VLA5; Cd49e;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cattle
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Flag
- Flag|His
- GST
- His (Fc)
- Avi
- His|Avi
- His|GST
- His|StrepII
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ITGA5 Related Research Area
ITGA5 involved in several pathways and played different roles in them. We selected most pathways ITGA5 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Phagosome | TLR4;PIKFYVE;FCAR;RAB5AB;FCGR2A;FCGR4;ATP6V1E1B;TUBA8L2;ACTB1 |
PIK-Akt signaling pathway | ITGB4;FOXO3;PRKAA1;PHLPP1;PPP2R2C;IFNA7;MCL1;RELA;IKBKG |
Focal adhesion | AASS;PRKCB;VEGFA;PARVAA;MYL12.2;PPP1CAA;LAMC3;LAMA1;COL27A1 |
ECM-receptor interaction | COL4A1;VWF;GP5;GP9;GP1BA;ITGB7;ITGB3B;ITGA3B;LAMB3 |
Hematopoietic cell lineage | ITGA1;EPO;CD1d1;CD1D;TNF;CSF1R;IL1R1;CD1E, B2M;CD1C |
Regulation of actin cytoskeleton | PDGFRA;FGF6;RAF1B;RHOAA;FGF10;ARHGEF7B;PIK3R1;FGD1;ACTN3 |
Bacterial invasion of epithelial cells | ARPC5L;CTNNA3;PIK3R3;ARPC4;ACTB;CD2AP;ARPC3;SEPT11;CRK |
Shigellosis | MAPK8;MAPK11;IKBKB;VCL;U2AF1L4;CD44;ROCK1;PFN2;ELMO2 |
Pertussis | CALM2;ITGB2;CASP7;Il23a;C3;IL1A;CALM4;NOS2;MAPK11 |
Proteoglycans in cancer | ARAF;DROSHA;FLNC;WNT9A;GPC1;PTPN6;TWIST1;FZD10;CCND1 |
MicroRNAs in cancer | NFKB1;RHOA;SHC1;SOX4;SLC7A1;TNXB;PLCG2;MDM2;MARCKS |
Hypertrophic cardiomyopathy (HCM) | TGFB2;ACTB;TPM4;PRKAA1;ITGA1;ACTC1;CACNA2D4;SGCG;CACNG8 |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | CTNNA1;SGCB;CACNG6;DAG1;SLC8A1;CACNG2;DES;ITGAV;CTNNA3 |
Dilated cardiomyopathy | CACNA2D3;CACNB3;ITGB7;ITGB1;TNNC1;ITGA3;SGCB;DAG1;PRKACA |
ITGA5 has several biochemical functions, for example, integrin binding, metal ion binding, platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA5 itself. We selected most functions ITGA5 had, and list some proteins which have the same functions with ITGA5. You can find most of the proteins on our site.
Function | Related Protein |
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integrin binding | ADAM17;IGF1;CTGF;Npnt;CIB2;ITGA5;ICAM5;ADAM25;NIPAL1 |
metal ion binding | CYP39A1;MOCS1;ACVR1;ZBTB22;CLEC4M;ZFYVE26;EBF3A;ZBTB6;ZDHHC20A |
platelet-derived growth factor receptor binding | PDGFAA;PDGFA;PDGFAB;PDGFC;Pdgfa&Pdgfb;PDGFRA;FIGF;PDGFB;PTPRJ |
protein binding | INO80;ANK2;ERLIN2;CENPK;DUSP5;PTPN4;PRIMPOL;SMPD1;TMSB10 |
vascular endothelial growth factor receptor 2 binding | ITGA5;PDCL3;GREM1;ITGB3;VEGFA |
virus receptor activity | CD86;ITGB1;MRC1;HYAL2;SERPINB4;SLC20A2;DAG1;CCR5;TNFRSF14 |
ITGA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA5.
ITGB1; SHARPIN; ENG; FN1; ganglioside_gm1; Rab21; PPAP2B
- Q&As
- Reviews
Q&As (7)
Ask a questionITGA5 works with extracellular matrix components, regulating cell-matrix interactions.
Altered ITGA5 activity can impact wound healing and tissue repair processes.
Genetic mutations in ITGA5 can lead to impaired cell adhesion and migration, affecting tissue integrity.
ITGA5, an integrin, is crucial for cell adhesion, facilitating cells' attachment to the extracellular matrix.
ITGA5 is involved in tissue remodeling, aiding in the reorganization and repair of tissues.
Targeting ITGA5 could offer new strategies for enhancing tissue repair and regeneration in various medical conditions.
It plays a key role in cell migration, essential for processes like wound healing and tissue formation.
Customer Reviews (3)
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