ITGA5 Protein, integrin alpha 5 (fibronectin receptor alpha)


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Official Full Name integrin alpha 5 (fibronectin receptor alpha)
Background Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats. Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain. Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
Synonyms ITGA5; integrin alpha 5 (fibronectin receptor alpha); integrin alpha-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor alpha polypeptide; Fnra; VLA5; Cd49e
    • Species :
    • Cattle
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag/His
    • Flag
    • His
    • GST
    • Avi
    • StrepII
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGA5&ITGB1-1878H Recombinant Human ITGA5 & ITGB1 protein, Flag/His-tagged HEK293 Flag/His
    Human ITGA5 & ITGB1-1877H Recombinant Human ITGA5 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGA5 & ITGB1-1878H Recombinant Human ITGA5 & ITGB1 protein, Flag & His-tagged HEK293 Flag/His
    Human ITGA5 & ITGB1-1877HCL Recombinant Human ITGA5 & ITGB1 cell lysate Human Cell N/A
    Human ITGA5&ITGB6-854HCL Recombinant Human ITGA5&ITGB6 cell lysate Human Cell N/A
    Human ITGA5-164H Recombinant Human ITGA5 & ITGB6, Flag & His tagged Human Cell His
    Human ITGA5-331H Recombinant Human ITGA5 Protein, GST-tagged HEK293 GST
    Human ITGA5-4116H Recombinant Human ITGA5, flag & His tagged Human Cell Flag/His
    Human ITGA5-4996H Recombinant Human ITGA5 Protein Wheat Germ N/A
    Human ITGA5-5132HCL Recombinant Human ITGA5 293 Cell Lysate HEK293 N/A
    Human ITGA5-5282H Recombinant Human ITGA5, Strep II-His-tagged HEK293 His/StrepII
    Human ITGA5-6771H Recombinant Human ITGA5 protein, His & GST-tagged E.coli His/GST
    Human ITGAVB3-101H Recombinant Human Integrin Alpha 5 Beta 3 Heterodimer Protein HEK293 N/A
    Mouse Itga5-6772M Recombinant Mouse Itga5 protein, His & GST-tagged E.coli His/GST
    Mouse ITGA5-8351M Recombinant Mouse ITGA5 Protein Mammalian Cell His
    Zebrafish ITGA5-1234Z Recombinant Zebrafish ITGA5 Mammalian Cell His
    Cattle ITGA5-6770C Recombinant Cattle ITGA5 protein, His & GST-tagged E.coli His/GST

    ITGA5 involved in several pathways and played different roles in them. We selected most pathways ITGA5 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway YWHAH; SPP1; DDIT4; NGFR; LAMC1; MET; IFNA6; CCNE1; COL6A6; EIF4E1B
    Focal adhesion PDPK1B; MET; PGF; PPP1CAA; AKT2L; VAV3; COL27A1B; ILK; PTENB; TNR
    ECM-receptor interaction GP1BA; THBS1; VTNA; TNR; GP6; LAMC1; CHAD; COL4A1; COL6A3; LAMA4
    Hematopoietic cell lineage CD8A; IL11RA2; IL9R; ANPEP; CR1; CD9; CR2; GM2002; CD1D2; ITGA3
    Regulation of actin cytoskeleton HRASA; FGF1B; PPP1CBL; ARHGEF7B; PAK3; RDX; BCAR1; EGFRA; Itga10&Itgb1; FGF3
    Bacterial invasion of epithelial cells ARPC2; HCLS1; PIK3CA; CDH1; SEPT2; SEPT11; CRKL; SHC1; CBL; CLTB
    Shigellosis ACTG1; MAPK8; CD44; U2AF1L4; SRC; NFKBIB; MAPK3; ACTB; ELMO3; MAPK10
    Pertussis CASP1; IL6; C1QB; SERPING1; IL12A; CFL2; C2; LY96; CALM1; CALML3
    Proteoglycans in cancer PIK3R1; GRB2; Ctsl; WNT11; TLR2; WNT6; PIK3R2; ITPR3; MDM2; ROCK2
    MicroRNAs in cancer PDGFB; MTOR; CCND1; HOXD10; ABCB1; ABL1; CYP24A1; BRCA1; VEGFA; BMPR2
    Hypertrophic cardiomyopathy (HCM) SGCD; TPM3; RYR2; CACNB2; DES; CACNB4; PRKAB1; ITGA2; CACNG8; TPM4
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) CACNG3; AASS; TCF7; DSG2; ITGAV; ITGB7; ACTN3; EMD; GJA1; ACTB
    Dilated cardiomyopathy TGFB2; ACTB; Itga10&Itgb1; CACNG6; ITGB8; ITGA4; CACNG8; ITGA1; CACNG2; IGF1

    ITGA5 has several biochemical functions, for example, integrin binding, metal ion binding, platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA5 itself. We selected most functions ITGA5 had, and list some proteins which have the same functions with ITGA5. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding LAMA5; ITGB1BP2; TLN1; ANXA7; ITGA3; ITGA5; FBN1; IGF1; JAM3; FAP
    metal ion binding ZNF823; ZFP740; Acsm2a; CYP2AA7; NRP2; CYP2K6; FAH; ZNF323; MAT2AA; ATP8A1
    platelet-derived growth factor receptor binding PDGFRB; PTEN; TYMP; IL1R1; LYN; ITGB3; PDGFD; PTPRJ; PDGFB; VEGFA
    vascular endothelial growth factor receptor 2 binding ITGB3; VEGFA; ITGA5; PDCL3; GREM1
    virus receptor activity CXCR4; TFRC; SLC20A2; HTR2A; ICAM1; CD209; CXADR; ITGA2; CLDN1; HYAL2

    ITGA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA5.

    ITGB1; SHARPIN; ENG; FN1; ganglioside_gm1; Rab21; PPAP2B

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