itga5
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  • Official Full Name
  • integrin alpha 5 (fibronectin receptor alpha)
  • Background
  • Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats. Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain. Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
  • Synonyms
  • ITGA5; integrin alpha 5 (fibronectin receptor alpha); integrin alpha-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor alpha polypeptide; Fnra; VLA5; Cd49e
Cat.#:ITGA5 & ITGB1-1877HTag:His-Avi
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA5 & ITGB1 Protein, His-Avi-tagged, Biotinylated
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Cat.#:ITGA5-4996HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ITGA5 Protein
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Cat.#:ITGA5-164HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA5 & ITGB6, Flag & His tagged
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Cat.#:ITGA5-331HTag:GST
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA5 Protein, GST-tagged
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Cat.#:ITGA5-4116HTag:Flag/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA5, flag & His tagged
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Cat.#:ITGA5-5282HTag:His/Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA5, Strep II-His-tagged
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Cat.#:ITGA5-6771HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ITGA5 protein, His & GST-tagged
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Cat.#:ITGAVB3-101HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Integrin Alpha 5 Beta 3 Heterodimer Protein
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Cat.#:Itga5-6772MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Itga5 protein, His & GST-tagged
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Cat.#:ITGA5-8351MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ITGA5 Protein
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Cat.#:ITGA5-1234ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ITGA5
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Cat.#:ITGA5-6770CTag:His/GST
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle ITGA5 protein, His & GST-tagged
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Cat.#:ITGA5 & ITGB1-1877HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA5 & ITGB1 cell lysate
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Cat.#:ITGA5&ITGB6-854HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ITGA5&ITGB6 cell lysate
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Cat.#:ITGA5-5132HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ITGA5 293 Cell Lysate
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Involved Pathway

ITGA5 involved in several pathways and played different roles in them. We selected most pathways ITGA5 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Phagosome
SCARB1; SEC61A1; NOX1; CTSL1B; ATP6V0D2; CCDC102A; DYNC2H1; CALRL2; SEC61G; ATP6V0A2B
PIK-Akt signaling pathway
YWHAG; KLK1B4; PRKAA2; SGK3; LAMC2; MAPK1; FIGF; EPO; LAMB1; GNB1
Focal adhesion
RAC3B; MAPK4; MYLPF; COL6A4; PDGFAA; MYL12A; THBS4B; VEGFC; TLN1; SPP1
ECM-receptor interaction
Npnt; ITGA5; SV2B; SV2C; ITGB6; CD44; COL6A6; THBS2; LAMA3; THBS1
Hematopoietic cell lineage
CSF3; GP5; IL6; IL1R2; FCER2; CR1; FLT3; GM-CSF; CD1B; IL1B
Regulation of actin cytoskeleton
INS2; ITGB5; PAK1; ITGA2; FGD3; BRAF; MYL12.1; INS1; RAC3A; WASB
Bacterial invasion of epithelial cells
ARPC5L; ILK; SHC4; PIK3R3; ELMO3; PIK3R1; ELMO1; ARPC1B; SEPT11; PXN
Shigellosis
ROCK2; ITGB1; WASL; ELMO2; MAPK3; SRC; BTRC; WASF1; U2AF1L4; PFN1
Pertussis
IL23; Il23a; Il12b; MAPK13; ITGA5; IRF3; IRF8; CALML5; CALML3; CXCL6; C1QC
Proteoglycans in cancer
WNT11; DDX5; SOS1; CAMK2G; FAS; PPP1R12A; PRKCB; PTK2; WNT5A; WNT3A
MicroRNAs in cancer
MTOR; FGFR3; STAT3; MMP16; ERBB3; ZFPM2; NFKB1; RHOA; KRAS; BMI1
Hypertrophic cardiomyopathy (HCM)
CACNA2D1; MYH7; ITGAV; MYBPC3; CACNB3; CACNG4; TPM2; TPM4; PRKAA2; ITGA6
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
DMD; SGCG; CACNB3; ACTN1; DSC2; JUP; CACNG8; ITGA10; ITGA9; ITGB6
Dilated cardiomyopathy
ITGB3; DAG1; CACNA2D4; ACTG1; TGFB1; ITGA6; GNAS; CACNA2D1; TPM2; TNNC1

Protein Function

ITGA5 has several biochemical functions, for example, integrin binding, metal ion binding, platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA5 itself. We selected most functions ITGA5 had, and list some proteins which have the same functions with ITGA5. You can find most of the proteins on our site.
Function
Related Protein
Function integrin binding
Related Protein LAMB2; ITGB6; NOV; CTGFA; ADAM17; P4HB; EGFL6; Tcam1; ACTN4; LAMB1
Function metal ion binding
Related Protein ZNF26; SUMF1; EYA3; CYP46A1.1; GBGT1; OVOL2; ADNPA; RXRBA; PRKD3; DOM3Z
Function platelet-derived growth factor receptor binding
Related Protein IL1R1; Pdgfa&Pdgfb; PDGFAB; PDGFC; PDGFB; PDGFRB; PDGFD; TYMP; ITGA5; LYN
Function protein binding
Related Protein FRA10AC1; CLCN1; NME2; ASCL4; TRAF2; VASP; SRSF10; COX4I2; NR4A2; CD2AP
Function vascular endothelial growth factor receptor 2 binding
Related Protein ITGB3; PDCL3; VEGFA; GREM1; ITGA5
Function virus receptor activity
Related Protein ITGA2; ITGB1; CR2; RPSA; PVRL1; HAVCR1; F11R; IDE; LDLR; NPC1

Interacting Protein

ITGA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA5.
ITGB1; SHARPIN; ENG; FN1; ganglioside_gm1; Rab21; PPAP2B