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ITGA5

  • Official Full Name

    integrin alpha 5 (fibronectin receptor alpha)

  • Overview

    Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats. Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain. Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions.
  • Synonyms

    ITGA5; integrin alpha 5 (fibronectin receptor alpha); integrin alpha-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor alpha polypeptide; Fnra; VLA5; Cd49e;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • Flag|His
  • GST
  • His (Fc)
  • Avi
  • His|Avi
  • His|GST
  • His|StrepII
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITGAVB3-101H Active Recombinant Human Integrin Alpha 5 Beta 3 Heterodimer Protein HEK293 N/A
Human ITGA5-5282H Active Recombinant Human ITGA5, Strep II-His-tagged HEK293 His/StrepII
Human ITGA5-6771H Recombinant Human ITGA5 protein, His & GST-tagged E.coli His/GST Glu895~Ala1049 (Accession # P08648)
Human ITGA5-164H Recombinant Human ITGA5 & ITGB6, Flag & His tagged Human Cell His
Human ITGA5-331H Recombinant Human ITGA5 Protein, GST-tagged HEK293 GST Phe42-Tyr995
Human ITGA5-4116H Recombinant Human ITGA5, flag & His tagged Human Cell Flag/His
Human ITGA5 & ITGB1-1877HCL Recombinant Human ITGA5 & ITGB1 cell lysate Human Cell N/A
Human ITGA5&ITGB6-854HCL Recombinant Human ITGA5&ITGB6 cell lysate Human Cell N/A
Human ITGA5-5132HCL Recombinant Human ITGA5 293 Cell Lysate HEK293 N/A
Human ITGA5-078H Recombinant Human ITGA5 Protein, C-His-tagged E.coli C-His
Human ITGA5-5170H Recombinant Human ITGA5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ITGA5-4996H Recombinant Human ITGA5 Protein Wheat Germ N/A
Human ITGA5-1211H-B Recombinant Human ITGA5 Protein Pre-coupled Magnetic Beads HEK293
Human ITGA5-1211H Recombinant Human ITGA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ITGA5-5724HF Recombinant Full Length Human ITGA5 Protein In Vitro Cell Free System 1,065 amino acids
Human ITGA5 & ITGB1-1877H Active Recombinant Human ITGA5 & ITGB1 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
Human ITGA5-0951H Recombinant Human ITGA5 Protein (Glu895-Ala1049), N-GST tagged E.coli N-GST Glu895-Ala1049
Human ITGA5-3122H Recombinant Human ITGA5 Protein (Phe42-Tyr995), C-His tagged Mammalian cells C-His Phe42-Tyr995
Human ITGA5&ITGB1-1878H Recombinant Human ITGA5 & ITGB1 protein, Flag/His-tagged HEK293 Flag/His 1745
Human ITGA5 & ITGB1-567H Recombinant Human ITGA5 & ITGB1 protein, His-Avi-tagged HEK293 His-Avi It contains Phe42-Tyr995 (P08648) acidic tail& Gln21-His 728 (P05556) basic tail.
Human ITGA5 & ITGB1-1878H Active Recombinant Human ITGA5 & ITGB1 protein, Flag & His-tagged HEK293 Flag/His
Human ITGA5-4320H Recombinant Human ITGA5 Protein (Met1-Tyr995), C-His tagged Mammalian cells C-His Met1-Tyr995
Human ITGA5-2935H Recombinant Human ITGA5 protein, His-tagged E.coli His 874-995 aa
Human ITGA5-2341H Recombinant Human ITGA5 Protein, His-tagged E.coli N-His Phe42-Asn664
Human ITGA5-1624HFL Recombinant Full Length Human ITGA5 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Itga5-6772M Recombinant Mouse Itga5 protein, His & GST-tagged E.coli His/GST Glu899~Ala1053 (Accession # P11688)
Mouse ITGA5-8351M Recombinant Mouse ITGA5 Protein Mammalian Cell His
Mouse Itga5-3596M Recombinant Mouse Itga5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse ITGA5-4638M-B Recombinant Mouse ITGA5 Protein Pre-coupled Magnetic Beads HEK293
Mouse ITGA5-4638M Recombinant Mouse ITGA5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Itga5-1697R Recombinant Rat Itga5 Protein, His-tagged E.coli N-His Asp516-Cys971
Cattle ITGA5-6770C Recombinant Cattle ITGA5 protein, His & GST-tagged E.coli His/GST Cys649~Arg900
Zebrafish ITGA5-1234Z Recombinant Zebrafish ITGA5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITGA5 Related Research Area

ITGA5 involved in several pathways and played different roles in them. We selected most pathways ITGA5 participated on our site, such as Phagosome, PIK-Akt signaling pathway, Focal adhesion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PhagosomeTLR4;PIKFYVE;FCAR;RAB5AB;FCGR2A;FCGR4;ATP6V1E1B;TUBA8L2;ACTB1
PIK-Akt signaling pathwayITGB4;FOXO3;PRKAA1;PHLPP1;PPP2R2C;IFNA7;MCL1;RELA;IKBKG
Focal adhesionAASS;PRKCB;VEGFA;PARVAA;MYL12.2;PPP1CAA;LAMC3;LAMA1;COL27A1
ECM-receptor interactionCOL4A1;VWF;GP5;GP9;GP1BA;ITGB7;ITGB3B;ITGA3B;LAMB3
Hematopoietic cell lineageITGA1;EPO;CD1d1;CD1D;TNF;CSF1R;IL1R1;CD1E, B2M;CD1C
Regulation of actin cytoskeletonPDGFRA;FGF6;RAF1B;RHOAA;FGF10;ARHGEF7B;PIK3R1;FGD1;ACTN3
Bacterial invasion of epithelial cellsARPC5L;CTNNA3;PIK3R3;ARPC4;ACTB;CD2AP;ARPC3;SEPT11;CRK
ShigellosisMAPK8;MAPK11;IKBKB;VCL;U2AF1L4;CD44;ROCK1;PFN2;ELMO2
PertussisCALM2;ITGB2;CASP7;Il23a;C3;IL1A;CALM4;NOS2;MAPK11
Proteoglycans in cancerARAF;DROSHA;FLNC;WNT9A;GPC1;PTPN6;TWIST1;FZD10;CCND1
MicroRNAs in cancerNFKB1;RHOA;SHC1;SOX4;SLC7A1;TNXB;PLCG2;MDM2;MARCKS
Hypertrophic cardiomyopathy (HCM)TGFB2;ACTB;TPM4;PRKAA1;ITGA1;ACTC1;CACNA2D4;SGCG;CACNG8
Arrhythmogenic right ventricular cardiomyopathy (ARVC)CTNNA1;SGCB;CACNG6;DAG1;SLC8A1;CACNG2;DES;ITGAV;CTNNA3
Dilated cardiomyopathyCACNA2D3;CACNB3;ITGB7;ITGB1;TNNC1;ITGA3;SGCB;DAG1;PRKACA

ITGA5 has several biochemical functions, for example, integrin binding, metal ion binding, platelet-derived growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA5 itself. We selected most functions ITGA5 had, and list some proteins which have the same functions with ITGA5. You can find most of the proteins on our site.

Function Related Protein
integrin bindingADAM17;IGF1;CTGF;Npnt;CIB2;ITGA5;ICAM5;ADAM25;NIPAL1
metal ion bindingCYP39A1;MOCS1;ACVR1;ZBTB22;CLEC4M;ZFYVE26;EBF3A;ZBTB6;ZDHHC20A
platelet-derived growth factor receptor bindingPDGFAA;PDGFA;PDGFAB;PDGFC;Pdgfa&Pdgfb;PDGFRA;FIGF;PDGFB;PTPRJ
protein bindingINO80;ANK2;ERLIN2;CENPK;DUSP5;PTPN4;PRIMPOL;SMPD1;TMSB10
vascular endothelial growth factor receptor 2 bindingITGA5;PDCL3;GREM1;ITGB3;VEGFA
virus receptor activityCD86;ITGB1;MRC1;HYAL2;SERPINB4;SLC20A2;DAG1;CCR5;TNFRSF14

ITGA5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA5.

ITGB1; SHARPIN; ENG; FN1; ganglioside_gm1; Rab21; PPAP2B

  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does ITGA5 interact with other components of the extracellular matrix? 10/12/2022

ITGA5 works with extracellular matrix components, regulating cell-matrix interactions.

What is the impact of altered ITGA5 activity on wound healing? 05/03/2020

Altered ITGA5 activity can impact wound healing and tissue repair processes.

How do genetic variations in ITGA5 affect cell function? 04/14/2020

Genetic mutations in ITGA5 can lead to impaired cell adhesion and migration, affecting tissue integrity.

What is the primary role of ITGA5 in cell adhesion? 03/01/2020

ITGA5, an integrin, is crucial for cell adhesion, facilitating cells' attachment to the extracellular matrix.

What role does ITGA5 play in tissue remodeling? 12/21/2018

ITGA5 is involved in tissue remodeling, aiding in the reorganization and repair of tissues.

What potential therapeutic applications arise from targeting ITGA5 in regenerative medicine? 02/15/2018

Targeting ITGA5 could offer new strategies for enhancing tissue repair and regeneration in various medical conditions.

How does ITGA5 contribute to cell migration? 04/04/2017

It plays a key role in cell migration, essential for processes like wound healing and tissue formation.

Customer Reviews (3)

Write a review
Reviews
10/15/2022

    Outstanding accuracy, accelerates research progress.

    08/02/2021

      Efficient service, essential for research outcomes.

      03/15/2021

        Trusted for research integrity, an invaluable research asset.

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