Recombinant Full Length Human ITGA5 Protein, C-Flag-tagged

• Cat.No.: ITGA5-1624HFL
• Product Overview: Recombinant Full Length Human ITGA5 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 110 kDa
• AA Sequence: MGSRTPESPLHAVQLRWGPRRRPPL LPLLLLLLPPPPRVGGFNLDAEAPA VLSGPPGSFFGFSVEFYRPG TDGVSVLVGAPKANTSQPGVLQGGA VYLCPWGASPTQCTPIEFDSKGSRL LESSLSSSEGEEPVEYKSLQ WFGATVRAHGSSILACAPLYSWRTE KEPLSDPVGTCYLSTDNFTRILEYA PCRSDFSWAAGQGYCQGGFS AEFTKTGRVVLGGPGSYFWQGQILS ATQEQIAESYYPEYLINLVQGQLQT RQASSIYDDSYLGYSVAVGE FSGDDTEDFVAGVPKGNLTYGYVTI LNGSDIRSLYNFSGEQMASYFGYAV AATDVNGDGLDDLLVGAPLL MDRTPDGRPQEVGRVYVYLQHPAGI EPTPTLTLTGHDEFGRFGSSLTPLG DLDQDGYNDVAIGAPFGGET QQGVVFVFPGGPGGLGSKPSQVLQP LWAASHTPDFFGSALRGGRDLDGNG YPDLIVGSFGVDKAVVYRGR PIVSASASLTIFPAMFNPEERSCSL EGNPVACINLSFCLNASGKHVADSI GFTVELQLDWQKQKGGVRRA LFLASRQATLTQTLLIQNGAREDCR EMKIYLRNESEFRDKLSPIHIALNF SLDPQAPVDSHGLRPALHYQ SKSRIEDKAQILLDCGEDNICVPDL QLEVFGEQNHVYLGDKNALNLTFHA QNVGEGGAYEAELRVTAPPE AEYSGLVRHPGNFSSLSCDYFAVNQ SRLLVCDLGNPMKAGASLWGGLRFT VPHLRDTKKTIQFDFQILSK NLNNSQSDVVSFRLSVEAQAQVTLN GVSKPEAVLFPVSDWHPRDQPQKEE DLGPAVHHVYELINQGPSSI SQGVLELSCPQALEGQQLLYVTRVT GLNCTTNHPINPKGLELDPEGSLHH QQKREAPSRSSASSGPQILK CPEAECFRLRCELGPLHQQESQSLQ LHFRVWAKTFLQREHQPFSLQCEAV YKALKMPYRILPRQLPQKER QVATAVQWTKAEGSYGVPLWIIILA ILFGLLLLGLLIYILYKLGFFKRSL PYGTAMEKAQLKPPATSDATRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton

Gene Information

• Gene Name: ITGA5 integrin subunit alpha 5 [ Homo sapiens (human) ]
• Official Symbol: ITGA5
• Synonyms: FNRA; CD49e; VLA-5; VLA5A
• Gene ID: 3678
• mRNA Refseq: NM_002205.5
• Protein Refseq: NP_002196.4
• MIM: 135620
• UniProt ID: P08648