Recombinant Human ITGA5 protein, His-tagged

• Cat.No.: ITGA5-2935H
• Product Overview: Recombinant Human ITGA5 protein(874-995 aa), fused to His tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole.
• Protein length: 874-995 aa
• AA Sequence: PINPKGLELDPEGSLHHQQKREAPS RSSASSGPQILKCPEAECFRLRCEL GPLHQQESQSLQLHFRVWAKTFLQR EHQPFSLQCEAVYKALKMPYRILPR QLPQKERQVATAVQWTKAEGSY
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.
• Reconstitution: Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage.
  Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage.

Gene Information

• Gene Name: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [ Homo sapiens ]
• Official Symbol: ITGA5
• Synonyms: ITGA5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); FNRA; integrin alpha-5; CD49e; VLA-5; integrin alpha-F; CD49 antigen-like family member E; fibronectin receptor subunit alpha; fibronectin receptor, alpha subunit; very late activation protein 5, alpha subunit; VLA5A
• Gene ID: 3678
• mRNA Refseq: NM_002205
• Protein Refseq: NP_002196
• MIM: 135620
• UniProt ID: P08648

Reviews

10/15/2022

Outstanding accuracy, accelerates research progress.

08/02/2021

Efficient service, essential for research outcomes.

03/15/2021

Trusted for research integrity, an invaluable research asset.

Q&As

How does ITGA5 interact with other components of the extracellular matrix?

ITGA5 works with extracellular matrix components, regulating cell-matrix interactions.

What is the impact of altered ITGA5 activity on wound healing?

Altered ITGA5 activity can impact wound healing and tissue repair processes.

How do genetic variations in ITGA5 affect cell function?

Genetic mutations in ITGA5 can lead to impaired cell adhesion and migration, affecting tissue integrity.

What is the primary role of ITGA5 in cell adhesion?

ITGA5, an integrin, is crucial for cell adhesion, facilitating cells' attachment to the extracellular matrix.

What role does ITGA5 play in tissue remodeling?

ITGA5 is involved in tissue remodeling, aiding in the reorganization and repair of tissues.

What potential therapeutic applications arise from targeting ITGA5 in regenerative medicine?

Targeting ITGA5 could offer new strategies for enhancing tissue repair and regeneration in various medical conditions.

How does ITGA5 contribute to cell migration?

It plays a key role in cell migration, essential for processes like wound healing and tissue formation.