mmp14
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  • Official Full Name
  • matrix metallopeptidase 14 (membrane-inserted)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP14; matrix metallopeptidase 14 (membrane-inserted); MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type-1 matrix metalloproteinase; 1
Cat.#:MMP14-181HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP14 Protein, His-tagged
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Cat.#:MMP14-5423HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP14 Protein, GST-tagged
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Cat.#:MMP14-571HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP14 Protein, MYC/DDK-tagged
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Cat.#:Mmp14-183MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp14 Protein, His-tagged
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Cat.#:MMP14-161HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human MMP14, His-tagged
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Cat.#:MMP14-162HTag:N/A
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human MMP14
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Cat.#:MMP14-84HTag:
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human MMP14 protein
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Cat.#:MMP14-160HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP14(Membrane-inserted), Catalytic Domain
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Cat.#:MMP14-1837HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP14 protein
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Cat.#:MMP14-38HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human MMP14, His-tagged
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Cat.#:MMP14-39HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP14, His-tagged
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Cat.#:MMP14-808HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP14
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Cat.#:MMP14-812HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP14, Hemopexin Domain, His-tagged
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Cat.#:MMP14-9909MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP14 Protein
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Cat.#:Mmp14-9911MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp14 protein, His-tagged
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Cat.#:MMP14-3713RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP14 Protein
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Cat.#:MMP14-2790RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MMP14 Protein, His-tagged
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Cat.#:MMP14-4279HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MMP14 293 Cell Lysate
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Cat.#:Kit-2123Tag:
Source (Host):Species:
Product nameMMP-14 Inhibitor Screening Kit
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Involved Pathway

MMP14 involved in several pathways and played different roles in them. We selected most pathways MMP14 participated on our site, such as TNF signaling pathway, GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TNF signaling pathway
CXCL3; CREB5; PIK3R2; Ccl12; PIK3R5; TNFRSF1B; ICAM1; CFLAR; DNM1L; TRAF3
GnRH signaling pathway
PLA2G4A; GRB2B; MAP3K3; PRKCA; CALM2A; GNA15.1; MAPK12B; HRASB; PLD1; FSHB

Protein Function

MMP14 has several biochemical functions, for example, calcium ion binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP14 itself. We selected most functions MMP14 had, and list some proteins which have the same functions with MMP14. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein OIT3; MASP2; PLA2G2E; CALM2; LTBP2; SLC25A23B; CABP4; ZZEF1; PCDHGA2; PLCB4
Function integrin binding
Related Protein WISP1A; Npnt; CTGF; ADAM25; ADAM15; MFGE8; LAMA5; COL3A1; SYK; FN1A
Function metalloendopeptidase activity
Related Protein YME1L1B; BMP1; ADAMTS4; ADAM18; MMP13; ADAMTS18; HE2; ADAMTSL4; ADAM20; ADAM12
Function peptidase activator activity
Related Protein MMP25; APP; PCOLCE2; FBLN1; MMP14; PSME4; CLPX; FN1; PINK1; PSME4B
Function protein binding
Related Protein TRAF3IP3; USP47; JAK2; PSMD7; CYBB; MTMR9; KCNH7; PGBD1; RABGEF1; NDUFB10
Function zinc ion binding
Related Protein ZCRB1; NR5A1A; WBP7; USP49; ZMYM4; MTF2; RNF141; TAF15; UBR1; TRIM69

Interacting Protein

MMP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP14.
ADI1; Gorasp2; LUM

MMP14 Related Articles

Oh, G; Yoo, SW; et al. Intravital imaging of mouse colonic adenoma using MMP-based molecular probes with multi-channel fluorescence endoscopy. BIOMEDICAL OPTICS EXPRESS 5:1677-1689(2014).
Ali, G; Borrelli, N; et al. Differential Expression of Extracellular Matrix Constituents and Cell Adhesion Molecules between Malignant Pleural Mesothelioma and Mesothelial Hyperplasia. JOURNAL OF THORACIC ONCOLOGY 8:1389-1395(2013).

MMP14 Related Gene Family

MMPs