MMP14 Protein, matrix metallopeptidase 14 (membrane-inserted)

MMP14

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MMP14

Official Full Name matrix metallopeptidase 14 (membrane-inserted)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Synonyms MMP14; matrix metallopeptidase 14 (membrane-inserted); MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type-1 matrix metalloproteinase; 1
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP14-84H Recombinant Human MMP14 protein E.coli N/A
    Human MMP14-160H Recombinant Human MMP14(Membrane-inserted), Catalytic Domain E.coli N/A
    Human MMP14-161H Recombinant Human MMP14, His-tagged NS0 His
    Human MMP14-162H Recombinant Human MMP14 Mammalian Cell N/A
    Human MMP14-181H Recombinant Human MMP14 Protein, His-tagged E.coli His
    Human MMP14-1837H Recombinant Human MMP14 protein E.coli N/A
    Human MMP14-38H Recombinant Human MMP14, His-tagged NS0 His
    Human MMP14-39H Recombinant Human MMP14, His-tagged E.coli His
    Human MMP14-4279HCL Recombinant Human MMP14 293 Cell Lysate HEK293 N/A
    Human MMP14-5423H Recombinant Human MMP14 Protein, GST-tagged Wheat Germ GST
    Human MMP14-571H Recombinant Human MMP14 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MMP14-808H Recombinant Human MMP14 E.coli N/A
    Human MMP14-812H Recombinant Human MMP14, Hemopexin Domain, His-tagged E.coli His
    Mouse Mmp14-183M Recombinant Mouse Mmp14 Protein, His-tagged E.coli His
    Mouse MMP14-9909M Recombinant Mouse MMP14 Protein Mammalian Cell His
    Mouse Mmp14-9911M Recombinant Mouse Mmp14 protein, His-tagged E.coli His
    Rat MMP14-3713R Recombinant Rat MMP14 Protein Mammalian Cell His
    Rhesus Macaque MMP14-2790R Recombinant Rhesus monkey MMP14 Protein, His-tagged Mammalian Cell His
    Kit-2123 MMP-14 Inhibitor Screening Kit N/A

    MMP14 involved in several pathways and played different roles in them. We selected most pathways MMP14 participated on our site, such as TNF signaling pathway, GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF signaling pathway MMP14; CREB3L2; TRADD; CXCL2; IL15; CXCL3; CXCL5; Casp3; TRAF2; AKT2
    GnRH signaling pathway PRKACAB; RAF1B; MAP2K2; GRB2; CALM3; CAMK2A; CACNA1D; MAPK12A; MAPK10; SRC

    MMP14 has several biochemical functions, for example, calcium ion binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP14 itself. We selected most functions MMP14 had, and list some proteins which have the same functions with MMP14. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PCDH2G5; MAN1A2; DLL4; MGP; CCDC48; RGN; GUCA1A; GPD2; PCDHA9; DNER
    integrin binding TNN; CTGFB; TSPAN8; NF2; WISP2; ITGB6; PTPN2; NOV; ADAMTS5; LYN
    metalloendopeptidase activity ADAM2; NPSN; PAPPAA; ADAM22; PMPCB; ADAM33; ADAMTS2; SPG7; ADAM9; PAPLN
    peptidase activator activity MMP14; APP; PSME4; PSME4B; FN1; PCOLCE; PCOLCE2; MMP25; CAV1; CLPX
    protein binding PDXP; PRDX3; GATSL3; AGXT; GNG4; ETNK1; UBE2M; FRMD7; LGALS2; LARP2
    zinc ion binding RNF146; MBTD1; ZFAND2A; NR1D2B; RBM4.2; LDB3; ZNF212; CSRP1B; PIAS2; ZFR

    MMP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP14.

    ADI1; Gorasp2; LUM

    Oh, G; Yoo, SW; et al. Intravital imaging of mouse colonic adenoma using MMP-based molecular probes with multi-channel fluorescence endoscopy. BIOMEDICAL OPTICS EXPRESS 5:1677-1689(2014).
    Ali, G; Borrelli, N; et al. Differential Expression of Extracellular Matrix Constituents and Cell Adhesion Molecules between Malignant Pleural Mesothelioma and Mesothelial Hyperplasia. JOURNAL OF THORACIC ONCOLOGY 8:1389-1395(2013).

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