|Official Full Name||matrix metallopeptidase 14 (membrane-inserted)|
|Background||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]|
|Synonyms||MMP14; matrix metallopeptidase 14 (membrane-inserted); MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; matrix metalloproteinase-14; membrane type 1 metalloprotease; membrane-type-1 matrix metalloproteinase; 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
MMP14 involved in several pathways and played different roles in them. We selected most pathways MMP14 participated on our site, such as TNF signaling pathway, GnRH signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|TNF signaling pathway||MMP14; CREB3L2; TRADD; CXCL2; IL15; CXCL3; CXCL5; Casp3; TRAF2; AKT2|
|GnRH signaling pathway||PRKACAB; RAF1B; MAP2K2; GRB2; CALM3; CAMK2A; CACNA1D; MAPK12A; MAPK10; SRC|
MMP14 has several biochemical functions, for example, calcium ion binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP14 itself. We selected most functions MMP14 had, and list some proteins which have the same functions with MMP14. You can find most of the proteins on our site.
|calcium ion binding||PCDH2G5; MAN1A2; DLL4; MGP; CCDC48; RGN; GUCA1A; GPD2; PCDHA9; DNER|
|integrin binding||TNN; CTGFB; TSPAN8; NF2; WISP2; ITGB6; PTPN2; NOV; ADAMTS5; LYN|
|metalloendopeptidase activity||ADAM2; NPSN; PAPPAA; ADAM22; PMPCB; ADAM33; ADAMTS2; SPG7; ADAM9; PAPLN|
|peptidase activator activity||MMP14; APP; PSME4; PSME4B; FN1; PCOLCE; PCOLCE2; MMP25; CAV1; CLPX|
|protein binding||PDXP; PRDX3; GATSL3; AGXT; GNG4; ETNK1; UBE2M; FRMD7; LGALS2; LARP2|
|zinc ion binding||RNF146; MBTD1; ZFAND2A; NR1D2B; RBM4.2; LDB3; ZNF212; CSRP1B; PIAS2; ZFR|
MMP14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP14 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP14.
ADI1; Gorasp2; LUM