Active Recombinant Human MMP14, His-tagged
Cat.No. : | MMP14-161H |
Product Overview : | Recombinant human MMP14 containing 6*his tag at Cterminalwas expressed in mouse myeloma cell, 60 kD (518aa). |
- Specification
- Gene Information
- Related Products
Cat. No. : | MMP14-161H |
Description : | Proteinsof the matrix metalloproteinase (MMP) family are involved in the breakdown ofextracellular matrix in normal physiological processes, such as embryonicdevelopment, reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's are secreted asinactive proproteins which are activated when cleaved by extracellularproteinases. However, the protein encoded by this gene is a member of themembrane-type MMP (MT-MMP) subfamily; each member of this subfamily containsa potential transmembrane domain suggesting that these proteins are expressedat the cell surface rather than secreted. This protein activates MMP2protein, and this activity may be involved in tumor invasion. |
Source : | Mammalian cells |
Species : | Human |
NterminalSequenceAnalysis : | Ala21 |
Activity : | Measured by its ability to cleave a fluorogenic peptide substrate McaKPLGLDpaARNH2.The specific activity is >500 pmol/min/μg. |
EndotoxinLevel : | <1.0 EU per 1 μg of the protein by the LAL method. |
Purity : | >80%, as determined by SDSPAGE. |
Formulation : | Supplied as a 0.2 μm filtered solution in Sodium Acetate, NaCl, CaCl2, Glycer-ol. |
Stability&Storage : | Use amanual defrost freezer and avoid repeated freezethaw cycles. 6 months fromdate of receipt, 70 °C as supplied. 3 months, 70 °C under sterileconditions after opening. |
OfficialSymbol : | MMP14 |
Gene Name : | MMP14 matrix metallopeptidase 14(membrane-inserted) [ Homo sapiens ] |
Synonyms : | MMP14; matrixmetallopeptidase 14 (membrane-inserted); 1; MMP-X1; MT-MMP; MT1MMP; MTMMP1;MT1-MMP; MT-MMP 1; matrix metalloproteinase-14; membrane type 1metalloprotease; membrane-type matrix metalloproteinase 1; membrane-type-1matrix metalloproteinase; MMP-14; EC 3.4.24.80; OTTHUMP00000027917; EC 3.4.24 |
Gene ID : | 4323 |
mRNA Refseq : | NM_004995 |
Protein Refseq : | NP_004986 |
MIM : | 600754 |
UniProt ID : | P50281 |
Chromosome Location : | 14q11-q12 |
Pathway : | Activation of Matrix Metalloproteinases; Extracellularmatrix organization; GnRH signaling pathway |
Function : | calcium ion binding; integrin binding; metalloendopeptidaseactivity |
Products Types
◆ Recombinant Protein | ||
MMP14-5599M | Recombinant Mouse MMP14 Protein, His (Fc)-Avi-tagged | +Inquiry |
MMP14-5423H | Recombinant Human MMP14 Protein, GST-tagged | +Inquiry |
MMP14-571H | Recombinant Human MMP14 Protein, MYC/DDK-tagged | +Inquiry |
MMP14-3369R | Recombinant Rat MMP14 Protein, His (Fc)-Avi-tagged | +Inquiry |
Mmp14-4098M | Recombinant Mouse Mmp14 Protein, Myc/DDK-tagged | +Inquiry |
◆ Lysates | ||
MMP14-4279HCL | Recombinant Human MMP14 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2123 | MMP-14 Inhibitor Screening Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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