myd88
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  • Official Full Name
  • myeloid differentiation primary response 88
  • Background
  • This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
  • Synonyms
  • MYD88; myeloid differentiation primary response 88; MYD88D; myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88);
Cat.#:MYD88-5796HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MYD88 Protein, GST-tagged
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Cat.#:MYD88-29151THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human MYD88
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Cat.#:MYD88-30HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MYD88 protein, MYC/DDK-tagged
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Cat.#:MYD88-7112HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MYD88, His-tagged
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Cat.#:MYD88-10293MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MYD88 Protein
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Cat.#:Myd88-1827MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Myd88 protein, His-tagged
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Cat.#:Myd88-1828RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Myd88 protein, His & GST-tagged
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Cat.#:MYD88-3843RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MYD88 Protein
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Cat.#:MYD88-2918RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MYD88 Protein, His-tagged
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Cat.#:MYD88-2650CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MYD88
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Cat.#:MYD88-12080ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MYD88
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Cat.#:MYD88-1550HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Myeloid Differentiation Primary Response Gene (88)
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Cat.#:MYD88-4034HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MYD88 293 Cell Lysate
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Involved Pathway

MYD88 involved in several pathways and played different roles in them. We selected most pathways MYD88 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYD88 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NF-kappa B signaling pathway
TNFRSF1A; PIAS4; BCL10; MAP3K7; TNFSF13B; IL-8; TRAF6; LBP; TICAM2; IL1B
Apoptosis
CASP9; IRAK3; PPP3CCB; TP53; BADB; HMGB2; PIK3R3B; HIST1H1D; PIK3CB; CASP8L1
Toll-like receptor signaling pathway
RIPK1; IRAK1; TLR1; MAP2K1; IL12A; CCL4L2; STAT1B; Ifna11; MAPK12A; RAC1
Salmonella infection
NOS2; CCL3; CCL4; RAC1A; TLR5B; IL-8; IL8L1; NLRC4; MAPK12B; NOS2A
Pertussis
MAPK13; MAPK11; Casp3; TRAF6; CD14; GNAI1; PYCARD; CALM2; IL1A; TICAM2
Legionellosis
C3; TLR2; IL1B; MYD88; EEF1A2; BNIP3; CASP7; IL6; RELA; NAIP6
Leishmaniasis
CR1; MAPK1; IFNGR2; HLA-DQA2; NCF1; FCGR2A; TAB2; Itgam&Itgb2; MAP3K7; TRAF6
Chagas disease (American trypanosomiasis)
IL6; GNAL; PIK3R3; MYD88; FOS; GNAS; IL10; MAPK12; TGFB2; MAPK10
African trypanosomiasis
THOP1; VCAM1; LAMA4; HBB; PLCB4; APOL1; IL1B; GNAQ; HPR; IL6
Malaria
HBB; KLRC4-KLRK1; CCL2; GYPA; ITGB2; SELP; IL12A; TLR4; VCAM1; IL18
Toxoplasmosis
HLA-DOA; HSPA6; AKT2; PIK3CD; TLR2; HLA-DQA2; LAMB2; IFNGR2; PIK3R5; GNAI3
Tuberculosis
SYK; HLA-DOB; IL1A; IFNB1; LSP1; Ifna15; HLA-DOA; RAB7A; HLA-DPB1; Pla2r1
Hepatitis B
PIK3R3; BAD; MAPK8; NRAS; Fasl; IFIH1; NFATC4; PIK3CA; STAT2; MYD88
Measles
CD209A; cgr2b; PIK3R3; PRKCQ; SH2D1A; PIK3R5; EIF2AK4; SLAMF1; TLR9; TNFRSF10D
Influenza A
TNFRSF10B; IFNA12; PIK3CG; EIF2AK4; ACTB; IFNA4; NLRX1; LOC100686744; HLA-DQA2; MAP2K1
Herpes simplex infection
TRAF6; PPP1CC; TBPL1; SKP2; TYK2; CLOCKA; STAT1B; BMA1; PKZ; OAS1B

Protein Function

MYD88 has several biochemical functions, for example, TIR domain binding, death receptor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYD88 itself. We selected most functions MYD88 had, and list some proteins which have the same functions with MYD88. You can find most of the proteins on our site.
Function
Related Protein
Function TIR domain binding
Related Protein MYD88
Function death receptor binding
Related Protein FEM1B; CASP8; NOL3; Casp3; FADD; BID; CFLAR; Fasl; TNFSF15; MYD88
Function identical protein binding
Related Protein SCAND1; PPPDE2; LRRK1; MMP9; PRDX3; SNX33; ERN1; PARK2; SHANK1; E2F7
Function protein binding
Related Protein PPP2R2A; CBR4; PAIP2; FAM125A; TP53INP1; GDNF; PAX3; CELF1; ADAMTS10; SCG5

Interacting Protein

MYD88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYD88 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYD88.
TIRAP; SPOP; TNFRSF13B

MYD88 Related Articles

Maeda, A; Bandow, K; et al. Induction of CXCL2 and CCL2 by pressure force requires IL-1 beta-MyD88 axis in osteoblasts. BONE 74:76-82(2015).
Huang, HF; Zeng, Z; et al. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. WORLD JOURNAL OF GASTROENTEROLOGY 21:2937-2948(2015).