MYD88
-
Official Full Name
myeloid differentiation primary response 88
-
Overview
This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] -
Synonyms
MYD88; myeloid differentiation primary response 88; MYD88D; myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- Myc
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- MYC
- Myc|DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- MYD88 Related Articles
- MYD88 Related Research Area
MYD88 involved in several pathways and played different roles in them. We selected most pathways MYD88 participated on our site, such as NF-kappa B signaling pathway, Apoptosis, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYD88 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
NF-kappa B signaling pathway | CCL4;LCK;CXCL2;ATM;CCL21B;ERC1;LBP;NFKB1;LRDD |
Apoptosis | DFFA;PPP3CCB;HIST1H1B;CDK5RAP2;PIK3R5;PPP3CA;DCC;PRKACA;CAPN2 |
Toll-like receptor signaling pathway | RELA;Ifna11;CD86;PIK3R2;CXCL9;NFKBIAA;CCL4L1;PIK3CG;IKBKG |
Salmonella infection | DYNC1LI2;PFN2L;ROCK2B;NFKB1;DYNC1I1;FLNB;TLR4BA;KLC2;TLR5B |
Pertussis | MAPK10;GNAI2;CALML3;Il23a; Il12b;IRAK4;MAPK13;CALM2;CASP1;SERPING1 |
Legionellosis | NAIP6;VCP;HSPD1;TNF;IL6;CXCL3;TLR4;CASP7;RAB1A |
Leishmaniasis | NCF1;TLR2;NCF2;HLA-DRA;Itgam&Itgb2;TGFB1;PRKCB;HLA-DQB1;TNF |
Chagas disease (American trypanosomiasis) | LOC100033925;TLR9;C1QC;GNA11;ACE;PLCB4;PPP2R2C;PPP2R2A;SMAD3 |
African trypanosomiasis | ICAM1;PLCB1;IFNG;IDO2;IL6;PLCB3;Fasl;PRKCA;IL18 |
Malaria | IL-8;TGFB1;THBS4;COMP;CD40LG;THBS2;Ccl12;TGFB3;TGFB2 |
Toxoplasmosis | TAB2;HLA-DPA1;Casp3;LAMC2;ITGB1;HLA-DRB1;TLR2;BIRC2;LAMB2 |
Tuberculosis | RFX5;RIPK2;BID;LSP1;HLA-DRA;PLK3;CAMK2B;TRADD;CARD9 |
Hepatitis B | MAPK1;RB1;PTK2B;MAP2K4;STAT2;AKT2;BAX;TGFB3;PIK3R3 |
Measles | AKT1;TNFRSF10A;TLR2;IFNAR2;PIK3R2;IL12A;IFNGR2;DOK1;OAS3 |
Influenza A | HLA-DPA1;IKBKE;PABPN1;DNAJB1;IFNB1;ADAR;IFNA16;XPO1;PML |
Herpes simplex infection | CRFB2;HLA-DOA;IFNPHI3;HLA-DPB1;HLA-DMB;TAB2;HCFC1;EIF2S1B;IRF3 |
MYD88 has several biochemical functions, for example, TIR domain binding, death receptor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MYD88 itself. We selected most functions MYD88 had, and list some proteins which have the same functions with MYD88. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
TIR domain binding | |
death receptor binding | FEM1B;PRDM4;NOL3;PIDD1;FADD;TMBIM1;MYD88;RIPK1;TNFSF15 |
identical protein binding | SEPHS1;AXIN1;CALCA;TNK2;GRASP;SH3GLB1;RGMB;TPCN2;COL2A1 |
protein binding | PLIN3;SFRS9;RPS6KA2;POLM;HIST1H2BE;BPIFA2;RTN3;SPTSSA;TOB1 |
MYD88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYD88 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYD88.
TIRAP; SPOP; TNFRSF13B
- Q&As
- Reviews
Q&As (5)
Ask a questionMYD88 recruits IRAK kinases to form the Myddosome complex, initiating a signaling cascade that culminates in the activation of NF-κB and pro-inflammatory gene expression.
MYD88 expression is tightly regulated at the transcriptional level by various factors, including transcription factors and epigenetic modifications.
MYD88 is a key mediator in the recognition of microbial components by TLRs, initiating signaling cascades that trigger immune responses against pathogens.
MYD88 activates NF-κB and MAPK signaling pathways, leading to the production of pro-inflammatory cytokines and interferons that orchestrate immune responses.
MYD88 plays a role in shaping adaptive immune responses by influencing the activation and differentiation of T and B cells, promoting an effective immune defense.
Customer Reviews (3)
Write a reviewTop-tier service—customer support's expertise ensured the perfect protein fit.
Dependable quality and service—this recombined protein is a lab favorite.
Rapid delivery, precise results—this product is a lab essential.
Ask a Question for All MYD88 Products
Required fields are marked with *
My Review for All MYD88 Products
Required fields are marked with *