MYD88

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MYD88

Official Full Name myeloid differentiation primary response 88
Background This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Synonyms MYD88; myeloid differentiation primary response 88; MYD88D; myeloid differentiation primary response protein MyD88; myeloid differentiation primary response gene (88);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MYD88-1550H Recombinant Human Myeloid Differentiation Primary Response Gene (88) E.coli N/A
    Human MYD88-29151TH Recombinant Human MYD88 Wheat Germ N/A
    Human MYD88-30H Recombinant Human MYD88 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MYD88-4034HCL Recombinant Human MYD88 293 Cell Lysate HEK293 N/A
    Human MYD88-5796H Recombinant Human MYD88 Protein, GST-tagged Wheat Germ GST
    Human MYD88-7112H Recombinant Human MYD88, His-tagged E.coli His
    Mouse MYD88-10293M Recombinant Mouse MYD88 Protein Mammalian Cell His
    Mouse Myd88-1827M Recombinant Mouse Myd88 protein, His-tagged E.coli His
    Rat Myd88-1828R Recombinant Rat Myd88 protein, His & GST-tagged E.coli His/GST
    Rat MYD88-3843R Recombinant Rat MYD88 Protein Mammalian Cell His
    Rhesus Macaque MYD88-2918R Recombinant Rhesus monkey MYD88 Protein, His-tagged Mammalian Cell His
    Chicken MYD88-2650C Recombinant Chicken MYD88 Mammalian Cell His
    Zebrafish MYD88-12080Z Recombinant Zebrafish MYD88 Mammalian Cell His

    MYD88 involved in several pathways and played different roles in them. We selected most pathways MYD88 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with MYD88 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway TRAF1; VCAM1; ATM; TLR4; BLNK; CXCL2; CFLAR; TNFSF14; UBE2I; NFKB2
    Apoptosis BNIP3LB; PRKACAA; RNF8; BAXB; TNFRSF10B; IRAK4; SPNA2; DERL3; STK26; HIST1H1C
    Toll-like receptor signaling pathway STAT1B; MAPK8A; PIK3CD; MAP2K4B; SPP1; IFNAR2; MAPK12B; IFNA6; IKBKB; MAP2K7
    Salmonella infection IFNGR1; DYNC1I2A; CCL3L3; KLC2; ROCK2A; IL1B; CCL4; NOS2; KLC1A; ACTB
    Pertussis IL12B; Il23a; Il12b; IRF8; FOS; IL23; C1QA; TNF; RHOA; C1QC; CALML3
    Legionellosis TLR5; NFKB2; CR1; CASP7; RAB1; RAB1B; RELA; SAR1B; EEF1G; HSF1
    Leishmaniasis HLA-DMA; HLA-DOA; MAP3K7; IL4; H2-AB1; FCGR2C; RELA; TGFB2; IFNGR1; FCGR3A
    Chagas disease (American trypanosomiasis) TLR9; MAPK10; NFKB1; GNA14; IFNGR1; MYD88; CD247; PLCB3; GNAI2; GNAO1
    African trypanosomiasis HBA1; THOP1; HBB-B1; MYD88; TNF; IL1B2; ICAM1; PRKCA; IL1B; IL10
    Malaria HBA1; CD40LG; THBS4; SDC1; DARC; CD81; CSF3; CD36; TLR4; GYPC
    Toxoplasmosis HLA-DPA1; PIK3CA; NFKB1; IFNGR1; HLA-DMA; LAMC1; LAMB4; IL10RA; LAMA4; GNAI3
    Tuberculosis CLEC4E; HLA-DRA; HLA-DMA; IL10RA; MRC2; H2-AA; BCL2; BAX; CLEC4M; ATP6V0A4
    Hepatitis B IFNA2; BCL2; IFNA7; NFKB1; CREB3L3; OSTN; CCND1; ELK1; NFATC1; TLR3
    Measles DDX58; TYK2; SH2D1A; HSPA2; STAT3; IL1B; TLR4; HSPA1B; PIK3R5; Il2
    Influenza A IFNA7; DNAJB1; IKBKB; TYK2; IL12B; ADAR; NLRX1; MAPK8; MAPK1; BMA1
    Herpes simplex infection BLB2; HLA-DRB5; IL12BA; SOCS3B; PPP1CB; C1QBP; OAS1; GTF2IRD1; HLA-B; Fasl

    MYD88 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by MYD88 itself. We selected most functions MYD88 had, and list some proteins which have the same functions with MYD88. You can find most of the proteins on our site.

    Function Related Protein
    TIR domain binding MYD88
    death receptor binding CFLAR; FADD; FEM1B; FASLG; TNFSF15; Casp3; BID; TMBIM1; NOL3; PRDM4
    identical protein binding SNRNP200; CBLL1; SHMT2; CSNK2B; CEP72; SH3GL1; RALYL; PRPF19; TPCN2; ATG101
    protein binding LARP4; MYH10; RNF11; ZHX1; STIM2; ARL4D; EEA1; OGT; TRMT61B; LOXL3

    MYD88 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MYD88 here. Most of them are supplied by our site. Hope this information will be useful for your research of MYD88.

    TIRAP; SPOP; TNFRSF13B

    Maeda, A; Bandow, K; et al. Induction of CXCL2 and CCL2 by pressure force requires IL-1 beta-MyD88 axis in osteoblasts. BONE 74:76-82(2015).
    Huang, HF; Zeng, Z; et al. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. WORLD JOURNAL OF GASTROENTEROLOGY 21:2937-2948(2015).

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