Recombinant Full Length Human MYD88 Protein, C-Flag-tagged

• Cat.No.: MYD88-687HFL
• Product Overview: Recombinant Full Length Human MYD88 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 33.1 kDa
• AA Sequence: MAAGGPGAGSAAPVSSTSSLPLAAL NMRVRRRLSLFLNVRTQVAADWTAL AEEMDFEYLEIRQLETQADP TGRLLDAWQGRPGASVGRLLELLTK LGRDDVLLELGPSIEEDCQKYILKQ QQEEAEKPLQVAAVDSSVPR TAELAGITTLDDPLGHMPERFDAFI CYCPSDIQFVQEMIRQLEQTNYRLK LCVSDRDVLPGTCVWSIASE LIEKRCRRMVVVVSDDYLQSKECDF QTKFALSLSPGAHQKRLIPIKYKAM KKEFPSILRFITVCDYTNPC
  TKSWFWTRLAKALSLPTRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome
• Protein Pathways: Apoptosis, Toll-like receptor signaling pathway

Gene Information

• Gene Name: MYD88 MYD88 innate immune signal transduction adaptor [ Homo sapiens (human) ]
• Official Symbol: MYD88
• Synonyms: IMD68; MYD88D
• Gene ID: 4615
• mRNA Refseq: NM_002468.5
• Protein Refseq: NP_002459.3
• MIM: 602170
• UniProt ID: Q99836