Map3k1 Protein, mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase


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Official Full Name mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Background MEKK1 is member of the serine/threonine protein kinase family and is a target in the JNK and ERK pathways. Phosphorylation of MEKK1 works with other kinases to activate cellular responses to mitogenic and metabolic stimuli.
Synonyms MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; MEKK1, mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; MAPKKK1; MEKK; MEK kinase 1; MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEKK1; SRXY6; MEKK 1
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K1-1037H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 1, GST-Tagged Sf9 Insect Cell GST
    Human MAP3K1-1540H Recombinant Human MAP3K1 protein, His & T7-tagged E.coli His/T7
    Human MAP3K1-30190TH Recombinant Human MAP3K1 Sf9 Insect Cell N/A
    Human MAP3K1-393H Recombinant Human MAP3K1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Rat MAP3K1-3563R Recombinant Rat MAP3K1 Protein Mammalian Cell His
    Rat Map3k1-665R Recombinant Rat Mitogen Activated Protein Kinase Kinase Kinase 1 E.coli N/A

    Map3k1 involved in several pathways and played different roles in them. We selected most pathways Map3k1 participated on our site, such as MAPK signaling pathway, Ubiquitin mediated proteolysis, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map3k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway FGFR1; MAP3K2; RAP1B; HSPA1L; PRKACBB; MEF2CB; FGFR4; MEF2C; PPM1A; MAPK13
    Ubiquitin mediated proteolysis CUL3; PML; FBXW11A; CUL3A; UBE2B; UBA3; UBR5; KEAP1B; RHOBTB1; ANAPC2
    RIG-I-like receptor signaling pathway MAPK8A; IKBKE; CXCL10; TRADD; OTUD5; IKBKB; MAPK8B; IFNA17; IL12BA; NFKBIAA
    Neurotrophin signaling pathway MAPK13; NFKBIA; SHC3; FOXO3; PLCG1; BAD; SH2B1; SH2B2; ARHGDIB; RAC1
    Hepatitis B CREB5; STAT1; IFNA17; IFNA8; Ifna15; MAP3K1; HBXIP; STAT2; MAPK8; CCNA2
    HTLV-I infection VCAM1; WNT3A; CDC20; Pdgfa&Pdgfb; MAPK8; TBP; CD3D; GSK3B; SRF; ETS2

    Map3k1 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Map3k1 itself. We selected most functions Map3k1 had, and list some proteins which have the same functions with Map3k1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NEK2; UBE2T; SYK; ATP1A1A.4; DNAH6; IP6K3; TWF2; PARS2; RLN1; MAP3K9
    JUN kinase kinase kinase activity MAP3K9; MAP3K11; MAP3K1; ALPK2; MAP3K10
    MAP kinase kinase kinase activity ALPK2; MAP3K1; STK3; RAF1; TAOK2; MAP3K14; MAP3K12; YSK4; TAOK3; ZAK
    protein binding TFR2; TK1; SMCR7; ZNF624; PFKFB1; TBX22; MC1R; IL12A; PHF23; ATP6AP2
    protein kinase activity CDK7; BMPR2A; CSNK1G2A; GRK7A; TEX14; DCLK3; TGFBR1A; RPS6KA3; RPS6KB1B; ERBB3A
    protein kinase binding CCNL2; PRKRIP1; KCNQ3; CHEK2; IL31RA; CALM; FAM83D; JIP1; IBTK; HNRNPA0
    zinc ion binding ZNF34; BTR06; CDA; PHC3; BBOX1; CSRP3; BTR29; ZCCHC9; NR2F6B; CXXC4

    Map3k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map3k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map3k1.


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