map3k1
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  • Official Full Name
  • mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
  • Background
  • MEKK1 is member of the serine/threonine protein kinase family and is a target in the JNK and ERK pathways. Phosphorylation of MEKK1 works with other kinases to activate cellular responses to mitogenic and metabolic stimuli.
  • Synonyms
  • MAP3K1; mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase; MEKK1, mitogen activated protein kinase kinase kinase 1; mitogen-activated protein kinase kinase kinase 1; MAPKKK1; MEKK; MEK kinase 1; MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MEKK1; SRXY6; MEKK 1
Cat.#:MAP3K1-393HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MAP3K1 Protein, MYC/DDK-tagged
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Cat.#:MAP3K1-1540HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP3K1 protein, His & T7-tagged
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Cat.#:MAP3K1-30190THTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MAP3K1
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Cat.#:MAP3K1-3563RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MAP3K1 Protein
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Cat.#:Map3k1-665RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mitogen Activated Protein Kinase Kinase Kinase 1
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Cat.#:MAP3K1-1037HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 1, GST-Tagged
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Involved Pathway

Map3k1 involved in several pathways and played different roles in them. We selected most pathways Map3k1 participated on our site, such as MAPK signaling pathway, Ubiquitin mediated proteolysis, RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Map3k1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG7A; PDGFA; RAF1A; FGF12; RPS6KA3B; PAK2A; GADD45G; PLA2G4F; ATF4B1; PPP3R1
Ubiquitin mediated proteolysis
UBE2D4; CUL3; ERCC8; MDM2; RHOBTB2; CDC20; FBXO4; RNF7; WWP2; PRPF19
RIG-I-like receptor signaling pathway
IL12BA; IL12B; Ifna15; TP-1; MAPK9; IKBKG; IFNK; IFNA4; RIPK1L; DDX58
Neurotrophin signaling pathway
KIDINS220; NFKBIE; NTF3; CALM4; MAPK3; BAX; SHC4; TP53; PIK3CD; PIK3R5
GnRH signaling pathway
MAP3K4; ATF4; CALM3; PTK2BB; CALM4; PLCB4; CACNA1D; MAPK12B; ADCY1B; MAP2K7
Hepatitis B
HBXIP; DDX3X; PRKCA; FAS; STAT6; SRC; IFN-a; IL6; IFNA12; IFNA14
HTLV-I infection
NFATC2; CREM; NFKB1; CRTC3; STAT5A; PIK3CD; ATF4; BUB1B; WNT6; TGFBR2

Protein Function

Map3k1 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Map3k1 itself. We selected most functions Map3k1 had, and list some proteins which have the same functions with Map3k1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein YARS; KIF12; TTN; ITPK1A; PRKD2; PTK2BB; GSS; UBE2R2; PDXK; ATP2B3B
Function JUN kinase kinase kinase activity
Related Protein MAP3K10; MAP3K11; ALPK2; MAP3K9; MAP3K1
Function MAP kinase kinase kinase activity
Related Protein MOS; MAP3K6; MAP3K3; RAF1; MAP3K13; MAP3K5; MAP3K12; KIAA1804; ZAK; TAOK1
Function protein binding
Related Protein TGM1; SLC2A4; SOX10; FAM49B; WDFY3; COX8A; VPREB1; DYNLL1; CDKN2AIP; CCPG1
Function protein kinase activity
Related Protein EGFRA; PRPF4BB; TEX14; PRKACAA; NPRL2; PKN1; ZNF143B; FGFR1B; PRKCBA; PIK3C3
Function protein kinase binding
Related Protein EEF2; FGR; TNIP2; MAP3K5; AGTR1A; CDK5; CAMK2N2; SHC4; CNPPD1; TUBB3
Function zinc ion binding
Related Protein NEURL1AA; SP110; CSRP1A; ADAT3; NANOS3; ZKSCAN5; PIAS3; ADAM10A; PRICKLE1B; CA2

Interacting Protein

Map3k1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Map3k1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Map3k1.
DCAF7; YWHAE; BRAF; MAP2K4; HSPA1L; TRAF2; ARRB2