|Official Full Name||nuclear receptor subfamily 1, group I, member 2|
|Background||PXR (also known as orphan nuclear receptor PXR, pregnane X receptor, orphan nuclear receptor PAR1, and steroid and xenobiotic receptor (SXR)) is a member of the nuclear hormone receptor family, NR1 subfamily containing a zinc finger domain. Alternatively|
|Synonyms||NR1I2; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1 group I member 2; BXR; ONR1; PAR2; PXR; SXR; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X n|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
NR1I2 involved in several pathways and played different roles in them. We selected most pathways NR1I2 participated on our site, such as Drug Induction of Bile Acid Pathway, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Drug Induction of Bile Acid Pathway||SLCO1B1; ABCC2; SLC51B; NR1I3; NR1I2; CYP7A1|
|Gene Expression||HNRNPA0B; ZNF350; ESR2B; TYW5; ZNF710; NR4A2A; POLRMT; SUZ12; SSRP1A; SUDS3|
|Generic Transcription Pathway||ZNF493; RNF111; ZNF498; ZNF3; ZNF354B; ZNF167; ZNF705A; ZNF701; ZNF253; ZNF480|
|Nuclear Receptor transcription pathway||NR2E3; NR2C2AP; NR2E1; NR6A1; NR1D2; NR2F1A; VDRB; NR6A1A; NR2C1; NR4A2A|
|Nuclear Receptors||NR2F1A; NR2F6; NR2F1; NR2F2; NR4A2A; NR2C2; RARG; NR1D2B; NR0B1; NR2E1|
|Nuclear receptors in lipid metabolism and toxicity||CYP27B1; RARGA; CYP26A1; VDRB; NR1I2; RARGB; ABCC2; CYP24A1; NR1I3; RARG|
NR1I2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1I2 itself. We selected most functions NR1I2 had, and list some proteins which have the same functions with NR1I2. You can find most of the proteins on our site.
|RNA polymerase II regulatory region sequence-specific DNA binding||ZNF548; ZNF583; CUX2; SP1; STOX1; ZBTB4; PLAGL1; CREBBP; ZNF773; NR1D1|
|RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding||NR6A1; Ar; RORCA; NR5A1A; AHR2; RORAA; AHR; NR2F6; NR1I3; NR2F6A|
|drug binding||FSCN1; PPARD; DAAM2; PDE10A; PDE4C; GRIK1; DCK; PIGC; MT2A; SMO|
|protein binding||CXXC5; ZRANB1; SPAG5; ASAP3; FSCN1; EFNA1; CRK; IL33; Kitl; ATE1|
|steroid hormone receptor activity||NR5A1B; RARB; GPR30; NR4A2A; NR1H5; NR6A1B; PAQR8; RORA; RARAB; PPARG|
|transcription coactivator activity||NR5A1; MNT; CRSP7; TAF10; KMT2E; MED12; TFAP2A; NCOA1; NFKB2; HIF3A|
|transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding||MAFA; STAG2; MAFBB; TBX5; ATF1; MYF6; CEBPA; SOHLH1; MSGN1; CREB3L3|
|zinc ion binding||FHL1B; LTN1; ADAM23; ING2; UBR4; TRAF1; MMP19; APEX2; S100A9; UBR7|
NR1I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1I2.
HSP90AB1; pxr-re_consensus_dna-probe; Sirt1; Ppargc1a; FGR; MAPK7; NFATC4; ATP6AP1; TFAP2C; SDF4; cp2c8_human_dr5-site_dna-probe