nr1i2
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  • Official Full Name
  • nuclear receptor subfamily 1, group I, member 2
  • Background
  • PXR (also known as orphan nuclear receptor PXR, pregnane X receptor, orphan nuclear receptor PAR1, and steroid and xenobiotic receptor (SXR)) is a member of the nuclear hormone receptor family, NR1 subfamily containing a zinc finger domain. Alternatively
  • Synonyms
  • NR1I2; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1 group I member 2; BXR; ONR1; PAR2; PXR; SXR; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X n
Cat.#:NR1I2-1300HTag:His-SUMO/MYC
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1I2 Protein, His-SUMO/MYC-tagged
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Cat.#:NR1I2-6073HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NR1I2 Protein, GST-tagged
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Cat.#:NR1I2-1896HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1I2, Ligand Binding Domain
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Cat.#:NR1I2-107HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Pregnane X receptor LBD/Hsp90 complex, GST-tagged
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Cat.#:NR1I2-1095HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Nuclear Receptor Subfamily 1, Group I, Member 2
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Cat.#:NR1I2-1356HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NR1I2, His-tagged
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Cat.#:NR1I2-31269THTag:
Source (Host):Species:Human
Product nameRecombinant Human NR1I2
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Cat.#:NR1I2-8489HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human NR1I2, His-tagged
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Cat.#:NR1I2-10859MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NR1I2 Protein
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Cat.#:Nr1i2-1085MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nr1i2 protein, His & GST-tagged
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Cat.#:Nr1i2-1086RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nr1i2 protein, His & GST-tagged
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Cat.#:NR1I2-4065RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NR1I2 Protein
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Cat.#:NR1I2-3093RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey NR1I2 Protein, His-tagged
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Cat.#:NR1I2-5691ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NR1I2
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Cat.#:NR1I2-3718HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NR1I2 293 Cell Lysate
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Involved Pathway

NR1I2 involved in several pathways and played different roles in them. We selected most pathways NR1I2 participated on our site, such as Drug Induction of Bile Acid Pathway, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Drug Induction of Bile Acid Pathway
SLCO1B1; NR1I2; CYP7A1; NR1I3; ABCC2; SLC51B
Gene Expression
ZNF227; METTL3; CDK9; SRSF11; COX16; NR4A2A; ZNF215; ZNF234; VDRB; RORAA
Generic Transcription Pathway
TUBB3; ZNF333; ZNF471; ZNF311; ZNF786; COX5B; ZNF222; ZNF582; SKI; ZNF747
Nuclear Receptor transcription pathway
NR1I3; ESRRGA; RARG; NRBF2; ESRRG; NR2C1; NR2F1; NR1D2A; RARAB; VDRB
Nuclear Receptors
NR2C2; NR2F1; NR0B1; NR1D2; NR2F6; RARG; RARGA; RORAA; NR2F1A; NR1H3
Nuclear receptors in lipid metabolism and toxicity
CYP27B1; VDRB; RARG; ABCC2; NR1I3; RARGA; NR1I2; CYP24A1; RARGB; CYP26A1

Protein Function

NR1I2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1I2 itself. We selected most functions NR1I2 had, and list some proteins which have the same functions with NR1I2. You can find most of the proteins on our site.
Function
Related Protein
Function RNA polymerase II regulatory region sequence-specific DNA binding
Related Protein FOXF2; PLAGL1; ZNF812; ELF5; ATF3; ZNF711; ATF5A; FOXD3; FOXC1; ZFAT
Function RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
Related Protein HNF4A; AHR; NR2F6A; HNF4G; RXRA; RORCA; NR2F6B; NR1I3; NR1H4; RORAA
Function drug binding
Related Protein DHODH; DHFR; SRP54; GSTP2; CYP4B1; HMGB2; TLR7; CHRNA3; PDE2A; DRD3
Function protein binding
Related Protein DDX58; CCDC170; MLF1; RANBP3; VCL; MDH1; REEP1; CALR; MICALL1; TOE1
Function steroid hormone receptor activity
Related Protein NR6A1B; RXRA; RARG; NR2F6B; PPARDB; RXRBB; RXRBA; VDR; ESRRG; RORB
Function transcription coactivator activity
Related Protein MED17; BRDT; NRIP1; SUB1A; SAP130; NFYC; MED12; WNT3A; TFDP1A; GMEB1
Function transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Related Protein TRP53; ATF5; MSGN1; MAFB; NR1I2; CREBBP; MAFGB; RAD21; EAF2; GATA2A
Function zinc ion binding
Related Protein CHURC1; RABGGTB; CA2; NEURL1B; ZNF276; NR1D4A; LHX8A; ZNF185; CSRP1A; NRAP

Interacting Protein

NR1I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1I2.
HSP90AB1; pxr-re_consensus_dna-probe; Sirt1; Ppargc1a; FGR; MAPK7; NFATC4; ATP6AP1; TFAP2C; SDF4; cp2c8_human_dr5-site_dna-probe

NR1I2 Related Articles

Huang, Q; Xue, JL; et al. NR4A1 is associated with chronic low-grade inflammation in patients with type 2 diabetes. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1648-1654(2014).
Xiao, SS; Zhou, YH; et al. CD44 affects the expression level of FOS-like antigen 1 in cervical cancer tissues. MOLECULAR MEDICINE REPORTS 9:1667-1674(2014).