NR1I2 Protein, nuclear receptor subfamily 1, group I, member 2


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Official Full Name nuclear receptor subfamily 1, group I, member 2
Background PXR (also known as orphan nuclear receptor PXR, pregnane X receptor, orphan nuclear receptor PAR1, and steroid and xenobiotic receptor (SXR)) is a member of the nuclear hormone receptor family, NR1 subfamily containing a zinc finger domain. Alternatively
Synonyms NR1I2; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1 group I member 2; BXR; ONR1; PAR2; PXR; SXR; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X n
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human NR1I2-107H Recombinant Human Pregnane X receptor LBD/Hsp90 complex, GST-tagged Sf9 Insect Cell GST
    Human NR1I2-1095H Recombinant Human Nuclear Receptor Subfamily 1, Group I, Member 2 Insect Cell N/A
    Human NR1I2-1300H Recombinant Human NR1I2 Protein, His-SUMO/MYC-tagged E.coli His/SUMO/Myc
    Human NR1I2-1356H Recombinant Human NR1I2, His-tagged E.coli His
    Human NR1I2-1896H Recombinant Human NR1I2, Ligand Binding Domain E.coli N/A
    Human NR1I2-31269TH Recombinant Human NR1I2 N/A
    Human NR1I2-3718HCL Recombinant Human NR1I2 293 Cell Lysate HEK293 N/A
    Human NR1I2-6073H Recombinant Human NR1I2 Protein, GST-tagged Wheat Germ GST
    Human NR1I2-8489H Recombinant Human NR1I2, His-tagged Sf21 Insect Cell His
    Mouse NR1I2-10859M Recombinant Mouse NR1I2 Protein Mammalian Cell His
    Mouse Nr1i2-1085M Recombinant Mouse Nr1i2 protein, His & GST-tagged E.coli His/GST
    Rat Nr1i2-1086R Recombinant Rat Nr1i2 protein, His & GST-tagged E.coli His/GST
    Rat NR1I2-4065R Recombinant Rat NR1I2 Protein Mammalian Cell His
    Rhesus Macaque NR1I2-3093R Recombinant Rhesus monkey NR1I2 Protein, His-tagged Mammalian Cell His
    Zebrafish NR1I2-5691Z Recombinant Zebrafish NR1I2 Mammalian Cell His

    NR1I2 involved in several pathways and played different roles in them. We selected most pathways NR1I2 participated on our site, such as Drug Induction of Bile Acid Pathway, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR1I2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Drug Induction of Bile Acid Pathway SLCO1B1; ABCC2; SLC51B; NR1I3; NR1I2; CYP7A1
    Gene Expression HNRNPA0B; ZNF350; ESR2B; TYW5; ZNF710; NR4A2A; POLRMT; SUZ12; SSRP1A; SUDS3
    Generic Transcription Pathway ZNF493; RNF111; ZNF498; ZNF3; ZNF354B; ZNF167; ZNF705A; ZNF701; ZNF253; ZNF480
    Nuclear Receptor transcription pathway NR2E3; NR2C2AP; NR2E1; NR6A1; NR1D2; NR2F1A; VDRB; NR6A1A; NR2C1; NR4A2A
    Nuclear Receptors NR2F1A; NR2F6; NR2F1; NR2F2; NR4A2A; NR2C2; RARG; NR1D2B; NR0B1; NR2E1
    Nuclear receptors in lipid metabolism and toxicity CYP27B1; RARGA; CYP26A1; VDRB; NR1I2; RARGB; ABCC2; CYP24A1; NR1I3; RARG

    NR1I2 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR1I2 itself. We selected most functions NR1I2 had, and list some proteins which have the same functions with NR1I2. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding ZNF548; ZNF583; CUX2; SP1; STOX1; ZBTB4; PLAGL1; CREBBP; ZNF773; NR1D1
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding NR6A1; Ar; RORCA; NR5A1A; AHR2; RORAA; AHR; NR2F6; NR1I3; NR2F6A
    drug binding FSCN1; PPARD; DAAM2; PDE10A; PDE4C; GRIK1; DCK; PIGC; MT2A; SMO
    protein binding CXXC5; ZRANB1; SPAG5; ASAP3; FSCN1; EFNA1; CRK; IL33; Kitl; ATE1
    steroid hormone receptor activity NR5A1B; RARB; GPR30; NR4A2A; NR1H5; NR6A1B; PAQR8; RORA; RARAB; PPARG
    transcription coactivator activity NR5A1; MNT; CRSP7; TAF10; KMT2E; MED12; TFAP2A; NCOA1; NFKB2; HIF3A
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding MAFA; STAG2; MAFBB; TBX5; ATF1; MYF6; CEBPA; SOHLH1; MSGN1; CREB3L3
    zinc ion binding FHL1B; LTN1; ADAM23; ING2; UBR4; TRAF1; MMP19; APEX2; S100A9; UBR7

    NR1I2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR1I2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR1I2.

    HSP90AB1; pxr-re_consensus_dna-probe; Sirt1; Ppargc1a; FGR; MAPK7; NFATC4; ATP6AP1; TFAP2C; SDF4; cp2c8_human_dr5-site_dna-probe

    Huang, Q; Xue, JL; et al. NR4A1 is associated with chronic low-grade inflammation in patients with type 2 diabetes. EXPERIMENTAL AND THERAPEUTIC MEDICINE 8:1648-1654(2014).
    Xiao, SS; Zhou, YH; et al. CD44 affects the expression level of FOS-like antigen 1 in cervical cancer tissues. MOLECULAR MEDICINE REPORTS 9:1667-1674(2014).

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