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Recombinant Mouse Nr1i2 protein, His & GST-tagged

Cat.No. : Nr1i2-1085M
Product Overview : Recombinant Mouse Nr1i2 aa. (Tyr205-Gly390 (Accession # O54915) fused with N-terminal His & GST tag was produced in E. coli cells.
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  • Gene Information
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Source : E. coli
Species : Mouse
Tag : His & GST
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 48.7kDa.
Protein length : Tyr205-Gly390 (Accession # O54915)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.6.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Nr1i2 nuclear receptor subfamily 1, group I, member 2 [ Mus musculus (house mouse) ]
Official Symbol : Nr1i2
Synonyms : Nr1i2; nuclear receptor subfamily 1, group I, member 2; PXR; SXR; PXR1; mPXR; PXR.1; PXR.2; nuclear receptor subfamily 1 group I member 2; Pregnane X receptor; orphan nuclear receptor PXR
Gene ID : 18171
mRNA Refseq : NM_001098404.1
Protein Refseq : NP_001091874.1
UniProt ID : O54915

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any diseases associated with dysregulation of NR1I2? 01/13/2022

Dysregulation of NR1I2 has been implicated in certain liver diseases and metabolic disorders, where impaired drug metabolism may contribute to disease progression.

How does NR1I2 influence the efficacy of chemotherapy drugs? 06/05/2021

NR1I2 can influence the metabolism of chemotherapy drugs, affecting their bioavailability and efficacy in cancer treatment.

Are there any drugs that specifically target NR1I2 for therapeutic purposes? 06/09/2020

Some drugs are designed to modulate NR1I2 activity for therapeutic purposes, aiming to enhance or inhibit its function based on the clinical context.

How does NR1I2 respond to xenobiotic exposure? 10/30/2019

NR1I2 is activated in response to xenobiotic exposure, leading to the upregulation of enzymes involved in detoxification and elimination of foreign substances.

Can genetic variations in NR1I2 influence drug response? 04/18/2017

Yes, genetic variations in NR1I2 can lead to inter-individual differences in drug metabolism, potentially impacting drug efficacy and safety.

Customer Reviews (3)

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Reviews
02/22/2023

    Their experienced team is dedicated to resolving any issues or challenges I may encounter during my experiments, providing prompt and effective solutions.

    03/02/2022

      The NR1I2 protein is renowned for its exceptional quality, making it a perfect match for my experimental requirements.

      10/22/2016

        In addition to its high-quality attributes, the manufacturer of the NR1I2 protein offers exemplary technical support.

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