Recombinant Human Pregnane X receptor LBD/Hsp90 complex, GST-tagged
Cat.No. : | NR1I2-107H |
Product Overview : | Recombinant Human GST-tagged Pregnane X receptor ligand-binding domain (PXR-LBD) consists of a 218 a.a. GST tag, a 14 a.a. flexible linker and a 233 a.a. PXR, NR1I2 ligand binding domain, Acc# AAH17304.2, amino acids 201-433. Human Pregnane X receptor ligand-binding domain (PXR-LBD) in complex with human Hsp90 was produced in insect cells co-infected with two recombinant baculoviruses. GST tagged PXR-LBD, Hsp90 and Hsc70 are the major components of the complex. |
- Specification
- Gene Information
- Related Products
Source : | Sf9 insect cells |
Species : | Human |
Tag : | GST |
Form : | 20 mM Na-P pH 8.0, 40 mM KCl, 20 mM Na2MoO4, 7 mM reduced glutathione, 15% glycerol. |
Purity : | >90% |
Applications : | Ligand binding and coactivator peptide recruitment assays. |
Storage : | Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice. |
Gene Name : | NR1I2 nuclear receptor subfamily 1, group I, member 2 [ Homo sapiens ] |
Official Symbol : | NR1I2 |
Synonyms : | NR1I2; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1 group I member 2; BXR; ONR1; PAR2; PXR; SXR; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X nuclear receptor variant 2; PAR; PRR; SAR; PAR1; PARq; |
Gene ID : | 8856 |
mRNA Refseq : | NM_003889 |
Protein Refseq : | NP_003880 |
MIM : | 603065 |
UniProt ID : | O75469 |
Chromosome Location : | 3q12-q13.3 |
Pathway : | Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem; Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem; |
Function : | drug binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription coactivator activity; zinc ion binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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