Recombinant Human NR1I2 Protein (Ser130-Ile431), His tagged

• Cat.No.: NR1I2-5260H
• Product Overview: Recombinant human NR1I2 (Ser130-Ile431) fused with His tag was expressed in E. coli.

Specification

• Description: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 34.89 kDa
• Protein Length: Ser130-Ile431
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: NR1I2 nuclear receptor subfamily 1, group I, member 2 [ Homo sapiens (human) ]
• Official Symbol: NR1I2
• Synonyms: NR1I2; nuclear receptor subfamily 1, group I, member 2; nuclear receptor subfamily 1 group I member 2; BXR; ONR1; PAR2; PXR; SXR; pregnane X receptor; orphan nuclear receptor PXR; orphan nuclear receptor PAR1; steroid and xenobiotic receptor; pregnane X nuclear receptor variant 2; PAR; PRR; SAR; PAR1; PARq
• Gene ID: 8856
• mRNA Refseq: NM_003889
• Protein Refseq: NP_003880
• MIM: 603065
• UniProt ID: O75469