pim1
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  • Official Full Name
  • pim-1 oncogene
  • Background
  • PIM-1 is a member of the serine/threonine kinase PIM oncogene family. PIM-1 has been implicated in lymphomagenesis, cell proliferation, apoptosis, differentiation and tumourigenesis. The PIM-1 protein kinase is upregulated in prostate cancer.
  • Synonyms
  • PIM1; pim-1 oncogene; PIM; serine/threonine-protein kinase pim-1; Oncogene PIM1; pim-1 kinase 44 kDa isoform; pim-1 oncogene (proviral integration site 1); proto-oncogene serine/threonine-protein kinase pim-1
Cat.#:PIM1-392HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Pim-1 Oncogene, GST-tagged, Active
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Cat.#:PIM1-168HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIM1 protein, GST-tagged
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Cat.#:PIM1-30290THTag:
Source (Host):Species:Human
Product nameRecombinant Human PIM1
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Cat.#:PIM1-310HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PIM1
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Cat.#:PIM1-551HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PIM1, GST-tagged
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Cat.#:PIM1-7553HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIM1, His-tagged
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Cat.#:PIM1-7906HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIM1 protein, His & GST-tagged
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Cat.#:Pim1-7907MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pim1 protein, His-tagged
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Cat.#:PIM1-4465RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIM1 Protein
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Cat.#:Pim1-7908RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pim1 protein, His-tagged
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Cat.#:PIM1-9086ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIM1
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Cat.#:PIM1-1288HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Pim-1 Oncogene, His-tagged
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Cat.#:PIM1-726HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Pim-1 Oncogene, GST-His
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Cat.#:PIM1-3181HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PIM1 293 Cell Lysate
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Cat.#:Kit-1619Tag:
Source (Host):Species:
Product namePIM1 Kinase Binding Assay Kit
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Involved Pathway

PIM1 involved in several pathways and played different roles in them. We selected most pathways PIM1 participated on our site, such as Jak-STAT signaling pathway, MicroRNAs in cancer, Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Jak-STAT signaling pathway
AOX2P; IL11RA; PIAS1; IL10RB; SOCS9; STAT5A; AKT2; STAT1; PIK3CA; PIK3R3A
MicroRNAs in cancer
CCNE2; PLCG2; RDX; DNMT1; ERBB2; RASSF1; SERPINB5; CD44; ST14; TTC6
Acute myeloid leukemia
BRAF; PML; SPI1; NRAS; RELA; HRAS; CCNA1; AKT1; MAP2K1; RARA

Protein Function

PIM1 has several biochemical functions, for example, ATP binding, manganese ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIM1 itself. We selected most functions PIM1 had, and list some proteins which have the same functions with PIM1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2I; SGK3; NAIP1; IKBKAP; ABCA6; ENTPD3; ORC4L; HARS; TAE1; BAT1
Function manganese ion binding
Related Protein MTPAP; PAPOLA; PPM1NB; FEN1; GYLTL1B; PPM1AB; GALNT1; B4GALT7; HMGCL; NUDT16
Function protein binding
Related Protein KIAA0247; MEF2A; TXLNA; UBE2I; CDKN1A; POT1A; RASL11A; HPN; COG8; PLK4
Function protein serine/threonine kinase activity
Related Protein MAPK8A; MOS; PRKACBA; MAP2K6; PKZ; ROCK2; AURKA; ULK1A; LIMK2; RPS6KA2
Function ribosomal small subunit binding
Related Protein DDX3X; PIM1; ERAL1; MTIF3; NPM1; NME1; CPEB2; DHX29; PTCD3
Function transcription factor binding
Related Protein TFDP1; RNF4; APBB3; HDAC11; BRD7; PIAS2; SLC26A5; PAX2; ESR1; APBB2

Interacting Protein

PIM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIM1.
RPS19; TFPT; FH; FXR2; NHLH1; BEND7

PIM1 Related Articles

Perera, GK; Ainali, C; et al. Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis. SCIENCE TRANSLATIONAL MEDICINE 6:-(2014).
Dourado, IBZ; Batista, WL; et al. Dual localization of Mdj1 in pathogenic fungi varies with growth temperature. MEDICAL MYCOLOGY 52:187-195(2014).