PODXL
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Official Full Name
podocalyxin-like
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Overview
This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. -
Synonyms
PODXL; podocalyxin-like; podocalyxin; Gp200; PC; PCLP; GCTM-2 antigen; podocalyxin-like protein 1; PCLP-1; MGC138240;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Yeast
- DDK|His
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PODXL Related Articles
- PODXL Related Research Area
PODXL involved in several pathways and played different roles in them. We selected most pathways PODXL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PODXL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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PODXL has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PODXL itself. We selected most functions PODXL had, and list some proteins which have the same functions with PODXL. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | GNG5;DCTN1;PIM3;INTS12;TRAPPC3;GRM6;MBNL3;DRD2;YY1 |
PODXL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PODXL here. Most of them are supplied by our site. Hope this information will be useful for your research of PODXL.
IQGAP1
- Q&As
- Reviews
Q&As (5)
Ask a questionPODXL promotes cancer cell migration and invasion, facilitating the spread of cancer to distant organs and tissues.
Yes, PODXL expression in CTCs can be a valuable biomarker for monitoring cancer progression and treatment response.
Yes, several clinical trials are investigating the efficacy of drugs targeting PODXL as a novel approach in cancer treatment.
Yes, targeting PODXL is being explored as a potential therapeutic strategy to inhibit cancer progression and metastasis.
Elevated PODXL expression is often associated with poor prognosis in cancer patients, indicating a more aggressive disease course.
Customer Reviews (3)
Write a reviewManufacturers may offer the option for custom protein production.
They can assist in identifying the most suitable experimental protocols or provide recommendations for optimal usage.
Manufacturers can provide researchers with purified and validated ARL5B protein, ensuring its quality and reliability for use in experiments and trials.
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