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Recombinant Human PODXL Protein (32-458 aa), His-tagged

Cat.No. : PODXL-1640H
Product Overview : Recombinant Human PODXL Protein (32-458 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.
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  • Gene Information
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Description : Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 46.2 kDa
Protein length : 32-458 aa
AA Sequence : QNATQTTTDSSNKTAPTPASSVTIM ATDTAQQSTVPTSKANEILASVKAT TLGVSSDSPGTTTLAQQVSGPVNTT VARGGGSGNPTTTIESPKSTKSADT TTVATSTATAKPNTTSSQNGAEDTT NSGGKSSHSVTTDLTSTKAEHLTTP HPTSPLSPRQPTSTHPVATPTSSGH DHLMKISSSSSTVAIPGYTFTSPGM TTTLLETVFHHVSQAGLELLTSGDL PTLASQSAGITASSVISQRTQQTSS QMPASSTAPSSQETVQPTSPATALR TPTLPETMSSSPTAASTTHRYPKTP SPTVAHESNWAKCEDLETQTQSEKQ LVLNLTGNTLCAGGASDEKLISLIC RAVKATFNPAQDKCGIRLASVPGSQ TVVVKEITIHTKLPAKDVYERLKDK WDELKEAGVSDMKLGDQGPPEEAED RF
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Gene Name : PODXL podocalyxin-like [ Homo sapiens ]
Official Symbol : PODXL
Synonyms : PODXL; podocalyxin-like; podocalyxin; Gp200; PC; PCLP; GCTM-2 antigen; podocalyxin-like protein 1; PCLP-1; MGC138240;
Gene ID : 5420
mRNA Refseq : NM_001018111
Protein Refseq : NP_001018121
MIM : 602632
UniProt ID : O00592

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does PODXL contribute to cancer metastasis? 02/09/2022

PODXL promotes cancer cell migration and invasion, facilitating the spread of cancer to distant organs and tissues.

Can PODXL be detected in circulating tumor cells (CTCs)? 07/26/2021

Yes, PODXL expression in CTCs can be a valuable biomarker for monitoring cancer progression and treatment response.

Are there ongoing clinical trials targeting PODXL in cancer therapy? 02/17/2021

Yes, several clinical trials are investigating the efficacy of drugs targeting PODXL as a novel approach in cancer treatment.

Are there therapeutic implications for targeting PODXL in cancer treatment? 03/22/2019

Yes, targeting PODXL is being explored as a potential therapeutic strategy to inhibit cancer progression and metastasis.

Can PODXL be used for prognosis in cancer patients? 04/03/2016

Elevated PODXL expression is often associated with poor prognosis in cancer patients, indicating a more aggressive disease course.

Customer Reviews (3)

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Reviews
03/22/2023

    Manufacturers may offer the option for custom protein production.

    02/26/2023

      They can assist in identifying the most suitable experimental protocols or provide recommendations for optimal usage.

      07/24/2017

        Manufacturers can provide researchers with purified and validated ARL5B protein, ensuring its quality and reliability for use in experiments and trials.

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