Recombinant Human PODXL Protein (32-458 aa), His-tagged
Cat.No. : | PODXL-1640H |
Product Overview : | Recombinant Human PODXL Protein (32-458 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial. |
- Specification
- Gene Information
- Related Products
Description : | Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma mbrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. |
Source : | Yeast |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer,50% glycerol |
Molecular Mass : | 46.2 kDa |
Protein length : | 32-458 aa |
AA Sequence : | QNATQTTTDSSNKTAPTPASSVTIM ATDTAQQSTVPTSKANEILASVKAT TLGVSSDSPGTTTLAQQVSGPVNTT VARGGGSGNPTTTIESPKSTKSADT TTVATSTATAKPNTTSSQNGAEDTT NSGGKSSHSVTTDLTSTKAEHLTTP HPTSPLSPRQPTSTHPVATPTSSGH DHLMKISSSSSTVAIPGYTFTSPGM TTTLLETVFHHVSQAGLELLTSGDL PTLASQSAGITASSVISQRTQQTSS QMPASSTAPSSQETVQPTSPATALR TPTLPETMSSSPTAASTTHRYPKTP SPTVAHESNWAKCEDLETQTQSEKQ LVLNLTGNTLCAGGASDEKLISLIC RAVKATFNPAQDKCGIRLASVPGSQ TVVVKEITIHTKLPAKDVYERLKDK WDELKEAGVSDMKLGDQGPPEEAED RF |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with reconstitution instruction is sent along with the products. |
Gene Name : | PODXL podocalyxin-like [ Homo sapiens ] |
Official Symbol : | PODXL |
Synonyms : | PODXL; podocalyxin-like; podocalyxin; Gp200; PC; PCLP; GCTM-2 antigen; podocalyxin-like protein 1; PCLP-1; MGC138240; |
Gene ID : | 5420 |
mRNA Refseq : | NM_001018111 |
Protein Refseq : | NP_001018121 |
MIM : | 602632 |
UniProt ID : | O00592 |
Products Types
◆ Recombinant Protein | ||
Podxl-4977M | Recombinant Mouse Podxl Protein, Myc/DDK-tagged | +Inquiry |
PODXL-2605H | Recombinant Human PODXL Protein, His-tagged | +Inquiry |
PODXL-3885H | Recombinant Human PODXL Protein, His (Fc)-Avi-tagged | +Inquiry |
PODXL-4217R | Recombinant Rat PODXL Protein, His (Fc)-Avi-tagged | +Inquiry |
Podxl-1956M | Recombinant Mouse Podxl Protein, His-tagged | +Inquiry |
◆ Lysates | ||
PODXL-3059HCL | Recombinant Human PODXL 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPODXL promotes cancer cell migration and invasion, facilitating the spread of cancer to distant organs and tissues.
Yes, PODXL expression in CTCs can be a valuable biomarker for monitoring cancer progression and treatment response.
Yes, several clinical trials are investigating the efficacy of drugs targeting PODXL as a novel approach in cancer treatment.
Yes, targeting PODXL is being explored as a potential therapeutic strategy to inhibit cancer progression and metastasis.
Elevated PODXL expression is often associated with poor prognosis in cancer patients, indicating a more aggressive disease course.
Customer Reviews (3)
Write a reviewManufacturers may offer the option for custom protein production.
They can assist in identifying the most suitable experimental protocols or provide recommendations for optimal usage.
Manufacturers can provide researchers with purified and validated ARL5B protein, ensuring its quality and reliability for use in experiments and trials.
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