| Description : |
Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. |
| Species : |
Mouse |
| Tag : |
His |
| Form : |
Liquid |
| Molecular Mass : |
41.0 kDa |
| Protein length : |
22-404 |
| AA Sequence : |
HNGNETSTSAIKSSTVQSHQSATTS TEVTTGHPVASTLASTQPSNPTPFT TSTQSPSMPTSTPNPTSNQSGGNLT SSVSEVDKTKTSSPSSTAFTSSSGQ TASSGGKSGDSFTTAPTTTLGLINV SSQPTDLNTTSKLLSTPTTDNTTSP QQPVDSSPSTASHPVGQHTPAAVPS SSGSTPSTDNSTLTWKPTTHKPLGT SEATQPLTSQTPGITTLPVSTLQQS MASTVGTTTEEFTHLISNGTPVAPP GPSTPSPIWAFGNYQLNCEPPIRPD EELLILNLTRASLCERSPLDEKEKL VELLCHSVKASFKPAEDLCTLHVAP ILDNQAVAVKRIIIETKLSPKAVYE LLKDRWDDLTEAGVSDMKLGKEGPP EVNEDRFSLEHHHHHH |
| Endotoxin : |
< 1.0 EU/μg of protein (determined by LAL method) |
| Purity : |
> 95 % by SDS-PAGE |
| Stability : |
Shelf life: one year from despatch. |
| Storage : |
Store undiluted at 2-8 centigrade for one week or (in aliquots) at -20 to -80 centigrade for longer. Avoid repeated freezing and thawing. |
| Concentration : |
0.5 mg/mL (determined by absorbance at 280nm) |
| Storage Buffer : |
Phosphate Buffered Saline (pH 7.4) containing 10 % glycerol. |
