PRMT5

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PRMT5

Official Full Name protein arginine methyltransferase 5
Background Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.
Synonyms PRMT5; protein arginine methyltransferase 5; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5; protein arginine N-methyltransferase 5; SKB1 homolog; jak-binding protein 1; 72 kDa ICln-binding protein; HMT1 hnRNP methyltransferase-like 5; shk1 kinase-binding protein 1 homolog; histone-arginine N-methyltransferase PRMT5;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Free Style 293-F Cell
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • His
    • GST
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRMT5-4447H Recombinant Human PRMT5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Prmt5-5133M Recombinant Mouse Prmt5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human PRMT5&MEP50-315H Recombinant Human PRMT5&MEP50 protein, Flag/His-tagged Insect Cell Flag/His
    Human PRMT5-1618H Recombinant Human Protein Arginine Methyltransferase 5, GST-tagged Sf9 Insect Cell GST
    Human PRMT5-177H Recombinant Human PRMT5 Protein, Flag-tagged Insect Cell Flag
    Human PRMT5-178H Recombinant Human PRMT5/MEP50 complex Protein, Flag/His-tagged Insect Cell Flag/His
    Human PRMT5-1969H Recombinant Human PRMT5, GST-tagged E.coli GST
    Human PRMT5-2321H Recombinant Human PRMT5, Flag & His tagged Human Cell Flag/His
    Human PRMT5-2577HCL Recombinant Human PRMT5 cell lysate Human Cell N/A
    Human PRMT5-3004H Recombinant Human PRMT5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PRMT5-32H Recombinant Human PRMT5/WDR77 protein, FLAG/His-tagged HEK293 Flag/His
    Human PRMT5-452H Recombinant Human Protein Arginine Methyltransferase 5 Free Style 293-F Cell N/A
    Human PRMT5-6962H Recombinant Human PRMT5, GST-tagged Sf9 Insect Cell GST
    Mouse PRMT5-13419M Recombinant Mouse PRMT5 Protein Mammalian Cell His
    Rhesus Macaque PRMT5-3614R Recombinant Rhesus monkey PRMT5 Protein, His-tagged Mammalian Cell His
    Zebrafish PRMT5-1659Z Recombinant Zebrafish PRMT5 Mammalian Cell His
    Kit-1858 PRMT5 Chemiluminescent Assay Kit N/A
    Kit-1859 PRMT5 Homogeneous Assay Kit N/A

    PRMT5 involved in several pathways and played different roles in them. We selected most pathways PRMT5 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chromatin modifying enzymes SAP30; COPRS; PADI1; PHF2; SMARCA2; KDM2A; PHF8; GATAD2AB; RBBP7; SMARCB1A
    Chromatin organization MORF4L1; SAP30L; SUZ12; COPRS; PADI6; RBBP5; ANO9A; MSL3; KDM5BB; PBRM1
    E2F transcription factor network CES5A; CES3; SMARCA2; MYBL2; CEBPA; TRIM28; HIC1; RBBP8; E2F4; CDKN2C
    Gene Expression DHX9; ZNF79; RORAA; AIMP2; MED15; DPY19L2; ANP32A; ZNF354B; ZNF543; LSM10
    Metabolism of non-coding RNA CLNS1A; DDX20; WDR77; PRMT5; SNUPN; PEAK1
    RMTs methylate histone arginines PBRM1; SMARCC2; SMARCC1; WDR77; SMARCB1B; PRMT5; SMARCD1; SMARCD3B; SMARCC1B; SMARCB1
    RNA transport EIF3H; POP5; THOC5; NUP210; EIF4A1A; UBE2IB; EEF1A1L1; EIF4G3; EIF3C; KPNB1
    Signaling events mediated by HDAC Class I MXD1; TFCP2; SIRT5; NR2C1; PRMT5; FKBP3; SIRT2; GATA1; SIRT4; GATA2

    PRMT5 has several biochemical functions, for example, core promoter sequence-specific DNA binding, histone-arginine N-methyltransferase activity, methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT5 itself. We selected most functions PRMT5 had, and list some proteins which have the same functions with PRMT5. You can find most of the proteins on our site.

    Function Related Protein
    core promoter sequence-specific DNA binding SOHLH1; ZFP932; PROX1; SOX4; ESR1; NRIP1; REST; NR4A3; MYOCD; NR1D1
    histone-arginine N-methyltransferase activity PRMT3; PRMT5; PRMT6; PRMT8; CARM1; PRMT2; PRMT7
    methyltransferase activity SMYD2B; METTL8; NTMT1; PRDM14; TOMT; SETD1B; PMT; SUV39H1A; GAMT; METTL18
    protein binding DESI1; DISC1; SNRPN; BRE; NDUFS3; HSCB; SF1; ACAA1; PCK2; RGS3
    protein complex binding LRP1; MLC1; ABP1; CCND1; MYO7A; BCAP31; HADHA; CPS1; MTHFR; PTK2B
    protein heterodimerization activity HIST1H2AB; LIFR; ABCG1; TXLNG; HIST1H4C; UGT1A4; SPNA1; TAS1R3; SUPT3H; UBA2
    protein-arginine N-methyltransferase activity METTL23; PRMT5; PRDM11; METTL21A; FBXO11; METTL7B; PRDM13; DIMT1; NDUFAF5; RNMTL1A
    protein-arginine omega-N symmetric methyltransferase activity PRMT5; PRMT7
    ribonucleoprotein complex binding PIGC; RNASEL; SRP54A; ITCH; TIMM50; SECISBP2; BOP1; PRMT5; PES; YBX2
    transcription corepressor activity NR0B1; UBP1; BASP1; SUFU; ERF; MYBBP1A; SKOR1A; HDAC3; ZHX1; AEBP2

    PRMT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT5.

    WDR77; YWHAZ; E2F1; CLNS1A

    Uzdensky, A; Demyanenko, S; et al. Expression of proteins involved in epigenetic regulation in human cutaneous melanoma and peritumoral skin. TUMOR BIOLOGY 35:8225-8233(2014).
    McLaughlin, N; Wang, FL; et al. In situ histone landscape of nephrogenesis. EPIGENETICS 9:222-235(2014).

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