PRMT5
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Official Full Name
protein arginine methyltransferase 5
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Overview
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. -
Synonyms
PRMT5; protein arginine methyltransferase 5; JBP1; SKB1; IBP72; SKB1Hs; HRMT1L5; protein arginine N-methyltransferase 5; SKB1 homolog; jak-binding protein 1; 72 kDa ICln-binding protein; HMT1 hnRNP methyltransferase-like 5; shk1 kinase-binding protein 1 homolog; histone-arginine N-methyltransferase PRMT5;
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- Mammalian cells
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- Flag|His
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
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- Involved Pathway
- Protein Function
- Interacting Protein
- PRMT5 Related Articles
- PRMT5 Related Research Area
PRMT5 involved in several pathways and played different roles in them. We selected most pathways PRMT5 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, E2F transcription factor network, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRMT5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Chromatin modifying enzymes | SMARCB1;KAT6B;KANSL2;HIST2H3C;PRMT7;VPS72;ARID4A;BRMS1;KDM7AB |
Chromatin organization | AEBP2;MCRS1;MSL2A;KAT6B;GATAD2A;KDM4B;CSRP2BP;SMARCD1;VPS72 |
E2F transcription factor network | TRIM28;DHFR;RYBP;HIC1;RBBP8;UXT;HBP1;CES3;E2F4 |
Gene Expression | EIF2S1;RBM5;SNAPC4;UBTF;ZNF274;PRDX2;ZBTB8OS;LAMTOR1;ZNF445 |
Metabolism of non-coding RNA | DDX20;SNUPN;WDR77;PEAK1;PRMT5;CLNS1A |
RMTs methylate histone arginines | PRMT7;PBRM1;PRMT6;ARID1A;SMARCB1A;SMARCD3;SMARCA4;SMARCC1;PBRM1L |
RNA transport | GEMIN2;EIF2S3Y;FXR1;EIF4BB;EIF4E1C;SRRM1;UBE2IA;RNPS1;NUP155 |
Signaling events mediated by HDAC Class I | GATA2;FKBP3;SIRT2;PRMT5;SIRT4;NR2C1;SIRT5;SIRT7;WDR77 |
PRMT5 has several biochemical functions, for example, core promoter sequence-specific DNA binding, histone-arginine N-methyltransferase activity, methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRMT5 itself. We selected most functions PRMT5 had, and list some proteins which have the same functions with PRMT5. You can find most of the proteins on our site.
Function | Related Protein |
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core promoter sequence-specific DNA binding | NRF1;PROX1;CREM;SOX4;REST;PDX1;MEOX1;CHD2;ATF4 |
histone-arginine N-methyltransferase activity | PRMT6;PRMT8;PRMT5;PRMT3;CARM1;PRMT2;PRMT7 |
methyltransferase activity | NSUN3;MLL1;C9orf114;METTL22;NSUN6;SETD1B;METTL17;THUMPD2;SETDB1B |
protein binding | GPM6A;MAP4K1;HNRNPM;SHFM1;RBBP6;NPHP3;TPX2;PTTG1IP;FAS |
protein complex binding | NDUFA8;CRIPT;VAMP2;STRN;YWHAB;KRAS;RNF40;CRHR1;EP300 |
protein heterodimerization activity | TAF9;PML;GRIN2A;TPD52L1;SOX32;NEFH;BOKA;HIST1H2AG;P2RY1 |
protein-arginine N-methyltransferase activity | METTL21D;DIMT1;PRDM13;FBXO11;TRMT10C;CARM1;FAM86;METTL21A;METTL7B |
protein-arginine omega-N symmetric methyltransferase activity | PRMT7;PRMT5 |
ribonucleoprotein complex binding | PRMT7;PES;CKAP5;RNASEL;SECISBP2;PPIH;PRMT5;PIGC;ITCH |
transcription corepressor activity | BATF3;ZHX3;YWHAB;ZFPM1;ID4;RLIM;E2F7;MXD1;HOMEZB |
PRMT5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRMT5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRMT5.
WDR77; YWHAZ; E2F1; CLNS1A
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, there are ongoing clinical trials investigating the efficacy of PRMT5 inhibitors in various cancer types.
PRMT5 influences cellular differentiation by regulating the expression of genes involved in the process.
Yes, there is interest in exploring combination therapies involving PRMT5 inhibitors with other anticancer agents to enhance treatment efficacy.
PRMT5 methylates histone proteins, leading to changes in chromatin structure and gene expression, thus playing a crucial role in epigenetic regulation.
PRMT5 has been implicated in neurodegenerative diseases, and understanding its role may provide insights into developing therapies for conditions like Alzheimer's and Parkinson's disease.
Customer Reviews (3)
Write a reviewGreat performance in ELISA.
Its purity and functionality ensure precise and reproducible results, enabling me to achieve my research objectives with confidence.
The PRMT5 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
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