Recombinant Human PRMT5 protein, GST-tagged

• Cat.No.: PRMT5-301624H
• Product Overview: Recombinant Human PRMT5 (283-637 aa) protein, fused to GST tag, was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: GST
• Form: The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8.). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization.
• Protein length: Tyr283-Leu637
• AA Sequence: YLEYLSQNRPPPNAYELFAKGYEDY LQSPLQPLMDNLESQTYEVFEKDPI KYSQYQQAIYKCLLDRVPEEEKDTN VQVLMVLGAGRGPLVNASLRAAKQA DRRIKLYAVEKNPNAVVTLENWQFE EWGSQVTVVSSDMREWVAPEKADII VSELLGSFADNELSPECLDGAQHFL KDDGVSIPGEYTSFLAPISSSKLYN EVRACREKDRDPEAQFEMPYVVRLH NFHQLSAPQPCFTFSHPNRDPMIDN NRYCTLEFPVEVNTVLHGFAGYFET VLYQDITLSIRPETHSPGMFSWFPI LFPIKQPITVREGQTICVRFWRCSN SKKVWYEWAVTAPVCSAIHNPTGRS YTIGL
• Purity: 85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
• Stability: Store for up to 12 months at -20°C to -80°C as lyophilized powder.
• Storage: Short-term storage: Store at 2-8°C for (1-2 weeks).
  Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles.

Gene Information

• Gene Name: PRMT5 protein arginine methyltransferase 5 [ Homo sapiens ]
• Official Symbol: PRMT5
• Synonyms: PRMT5; protein arginine methyltransferase 5; HRMT1L5, SKB1, skb1 (S. pombe) homolog , SKB1 homolog (S. pombe); protein arginine N-methyltransferase 5; SKB1Hs; SKB1 homolog; jak-binding protein 1; 72 kDa ICln-binding protein; HMT1 hnRNP methyltransferase-like 5; shk1 kinase-binding protein 1 homolog; histone-arginine N-methyltransferase PRMT5; JBP1; SKB1; IBP72; HRMT1L5
• Gene ID: 10419
• mRNA Refseq: NM_001039619
• Protein Refseq: NP_001034708
• MIM: 604045
• UniProt ID: O14744

Reviews

02/18/2023

Great performance in ELISA.

11/01/2018

Its purity and functionality ensure precise and reproducible results, enabling me to achieve my research objectives with confidence.

10/30/2016

The PRMT5 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

Q&As

Are there any ongoing clinical trials targeting PRMT5?

Yes, there are ongoing clinical trials investigating the efficacy of PRMT5 inhibitors in various cancer types.

How does PRMT5 affect cellular differentiation?

PRMT5 influences cellular differentiation by regulating the expression of genes involved in the process.

Can PRMT5 inhibitors be used in combination therapies?

Yes, there is interest in exploring combination therapies involving PRMT5 inhibitors with other anticancer agents to enhance treatment efficacy.

How does PRMT5 contribute to epigenetic regulation?

PRMT5 methylates histone proteins, leading to changes in chromatin structure and gene expression, thus playing a crucial role in epigenetic regulation.

How does PRMT5 influence neurodegenerative diseases?

PRMT5 has been implicated in neurodegenerative diseases, and understanding its role may provide insights into developing therapies for conditions like Alzheimer's and Parkinson's disease.