Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512

Recombinant Human PRMT5/WDR77 protein, FLAG/His-tagged

Cat.No. : PRMT5-32H
Product Overview : Recombinant Human PRMT5/WDR77(a.a: 2–end (both)) fused with N-terminal FLAG-tag (PRMT5) and N-terminal His-tag (WDR77) was expressed in FreeStyle 293-F cells.
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. Type II PRMTs are found to be strongly implicated in diseases like cancer. For example, PRMT5 plays a role in the repression of certain tumor suppressor genes such as RB tumor suppressors while PRMT7 overexpression is observed in breast cancer
Source : HEK293
Species : Human
Tag : FLAG/His
Form : 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 80 µg/ml Flag peptide, and 20% glycerol.
Molecular Mass : 73 kDa (PRMT5), 37.5 kDa (MEP50)
Purity : >75%
Applications : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Storage : At least 6 months at -80 centigrade. Avoid freeze/thaw cycles.
Gene Name : PRMT5 protein arginine methyltransferase 5 [ Homo sapiens ]
Official Symbol : PRMT5
Synonyms : PRMT5; protein arginine methyltransferase 5; HRMT1L5, SKB1, skb1 (S. pombe) homolog , SKB1 homolog (S. pombe); protein arginine N-methyltransferase 5; SKB1Hs; SKB1 homolog; jak-binding protein 1; 72 kDa ICln-binding protein; HMT1 hnRNP methyltransferase-like 5; shk1 kinase-binding protein 1 homolog; histone-arginine N-methyltransferase PRMT5; JBP1; SKB1; IBP72; HRMT1L5;
Gene ID : 10419
mRNA Refseq : NM_006109
Protein Refseq : NP_006100
MIM : 604045
UniProt ID : O14744
Chromosome Location : 14q11.2
Pathway : E2F transcription factor network, organism-specific biosystem; Gene expression, organism-specific biosystem; Metabolism of non-coding RNA, organism-specific biosystem; RNA transport, organism-specific biosystem; RNA transport, conserved biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; p53 pathway, organism-specific biosystem;
Function : histone-arginine N-methyltransferase activity; methyltransferase activity; protein binding; protein-arginine omega-N symmetric methyltransferase activity; ribonucleoprotein complex binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any ongoing clinical trials targeting PRMT5? 05/31/2021

Yes, there are ongoing clinical trials investigating the efficacy of PRMT5 inhibitors in various cancer types.

How does PRMT5 affect cellular differentiation? 12/10/2019

PRMT5 influences cellular differentiation by regulating the expression of genes involved in the process.

Can PRMT5 inhibitors be used in combination therapies? 07/05/2018

Yes, there is interest in exploring combination therapies involving PRMT5 inhibitors with other anticancer agents to enhance treatment efficacy.

How does PRMT5 contribute to epigenetic regulation? 04/26/2016

PRMT5 methylates histone proteins, leading to changes in chromatin structure and gene expression, thus playing a crucial role in epigenetic regulation.

How does PRMT5 influence neurodegenerative diseases? 01/04/2016

PRMT5 has been implicated in neurodegenerative diseases, and understanding its role may provide insights into developing therapies for conditions like Alzheimer's and Parkinson's disease.

Customer Reviews (3)

Write a review
Reviews
02/18/2023

    Great performance in ELISA.

    11/01/2018

      Its purity and functionality ensure precise and reproducible results, enabling me to achieve my research objectives with confidence.

      10/30/2016

        The PRMT5 protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

        Ask a Question for All PRMT5 Products

        Required fields are marked with *

        My Review for All PRMT5 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends