rbp4
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  • Official Full Name
  • retinol binding protein 4, plasma
  • Background
  • This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
  • Synonyms
  • RBP4; retinol binding protein 4, plasma; RDCCAS; retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial; Retinol-binding protein 4; Plasma retinol-binding protein
Cat.#:RBP4-738HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RBP4 Protein, MYC/DDK-tagged
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Cat.#:RBP4-30009THTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human RBP4, FLAG-tagged
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Cat.#:RBP4-354HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RBP4
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Cat.#:RBP4-3717HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RBP4, His-tagged
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Cat.#:RBP4-442HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human RBP4 protein, His-tagged
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Cat.#:RBP4-52HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human RBP4
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Cat.#:RBP4-836HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human RBP4, His tagged
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Cat.#:RBP4-211MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse RBP4, His tagged
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Cat.#:Rbp4-446MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rbp4, His-tagged
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Cat.#:Rbp4-447MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Rbp4, FLAG-tagged
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Cat.#:Rbp4-2388RTag:Flag
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Retinol Binding Protein 4, Plasma, FLAG-tagged
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Cat.#:Rbp4-448RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Rbp4, His-tagged
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Cat.#:Rbp4-7427RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Rbp4, His tagged
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Cat.#:RBP4-112CTag:Flag/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RBP4, His tagged
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Cat.#:RBP4-1035CTag:Fc
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine RBP4 Protein, Fc-tagged
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Cat.#:RBP4-1036CTag:His
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine RBP4 Protein, His-tagged
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Cat.#:RBP4-5634CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken RBP4 protein, His-tagged
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Cat.#:RBP4-6791CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RBP4
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Cat.#:RBP4-8561ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RBP4
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Cat.#:RBP4-1757CTag:His
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle RBP4 protein, His-tagged
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Cat.#:RBP4-5635PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig RBP4 protein, His-tagged
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Cat.#:RBP4-111HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Retinol Binding Protein 4, Plasma
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Cat.#:RBP4-112HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RBP4, His-tagged
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Cat.#:RBP4-247HTag:
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Retinol Binding Protein 4
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Cat.#:RBP4-2863HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human RBP4 cell lysate
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Cat.#:RBP4-2304MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse RBP4 cell lysate
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Cat.#:RBP4-2271RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat RBP4 cell lysate
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Cat.#:RBP4-1045CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RBP4 cell lysate
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Cat.#:RBP4-1517CCLTag:
Source (Host):HEK293Species:Canine
Product nameRecombinant Canine RBP4 cell lysate
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Cat.#:RBP4-214RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Retinol Binding Protein 4, Plasma, His-tagged
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Involved Pathway

RBP4 involved in several pathways and played different roles in them. We selected most pathways RBP4 participated on our site, such as Disease, Diseases associated with visual transduction, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Disease
NUP35; OS9; FDX1; ACAN; STX1B; CCNC; CHMP4C; FDX1L; STRA6; SYT2
Diseases associated with visual transduction
OPN1SW; STRA6; OPN1MW; OPN1MW2; TTR; RBP4; RBP1; OPN1LW; RLBP1
Diseases of signal transduction
CDK8; CTBP1; JAG1; TTR; FKBP1A; RNF43; DERL2; OPN1SW; CCNC; RBP4
Retinoid cycle disease events
RLBP1; RBP4; STRA6; RBP1
Retinoid metabolism and transport
BCO2; LRP10; APOM; APOA4A; RBP2A; RBP1; APOC2; CLPS; AKR1C4; APOA4B.1
SREBP signalling
INSIG1; RNF139; SEC23B; INSIG2; DBI; RBP4
Signal Transduction
ROR2; ARHGAP44; NMT1A; ACVR1C; RYK; XK; PNOCB; OXGR1A.1; RLBP1A; CD97
The canonical retinoid cycle in rods (twilight vision)
RDH12; MYO7AA; RLBP1A; RBP3; ABCA4A; DHRS9; STRA6; RBP4; IRBP; RPE65A

Protein Function

RBP4 has several biochemical functions, for example, protein binding, protein heterodimerization activity, retinal binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBP4 itself. We selected most functions RBP4 had, and list some proteins which have the same functions with RBP4. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein GOPC; PRLHR; ZBP1; U2AF1; ACAN; CRBN; NPAS2; NR5A2; KRT5; NEGR1
Function protein heterodimerization activity
Related Protein TWIST1; PDGFA; EGFR; POLE4; HIST3H2A; TYRO3; ATF4; UGT1A6B; ENO3; KCNK9
Function retinal binding
Related Protein RBP2A; RBP4; RBP2; RBP5; CRABP1; CRABP2; RBP1; RBP2B; RBP3; RBP7
Function retinol binding
Related Protein RBP4; LRAT; RBP7; ADH4; ADH7; RBP2; RBP3; RBP1; CRABP2; C8G
Function retinol transporter activity
Related Protein RBP4

Interacting Protein

RBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBP4.
TTR; TTR; GRB2; q9wmx2-pro_0000037550

RBP4 Related Articles

Hu, ZY; Lausted, C; et al. Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity. THERANOSTICS 4:215-228(2014).
Kotnik, P; Keuper, M; et al. Interleukin-1 beta Downregulates RBP4 Secretion in Human Adipocytes. PLOS ONE 8:-(2013).