sirt1
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  • Official Full Name
  • sirtuin 1
  • Background
  • This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
  • Synonyms
  • SIRT1; sirtuin 1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1;
Cat.#:SIRT1-11HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRT1 Protein, MYC/DDK-tagged
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Cat.#:SIRT1-100MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse SIRT1 Protein, His-tagged
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Cat.#:SIRT1-1165HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT1, His tagged
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Cat.#:SIRT1-132HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT1, His-tagged
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Cat.#:SIRT1-190HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human SIRT1 Protein, His-tagged
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Cat.#:SIRT1-30565THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT1
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Cat.#:SIRT1-31404THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT1, His-tagged
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Cat.#:SIRT1-462HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT1, GST-tagged
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Cat.#:SIRT1-463HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT1, His-tagged
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Cat.#:SIRT1-4873HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sirtuin 1, His-tagged
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Cat.#:SIRT1-4874HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 1, GST-tagged
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Cat.#:SIRT1-658HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT1, His-tagged
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Cat.#:SIRT1-698HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SIRT1
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Cat.#:Sirt1-1374RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirt1 protein, His-tagged
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Cat.#:SIRT1-1238CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIRT1
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Cat.#:SIRT1-1360HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SIRT1 (Active), His-tagged
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Cat.#:SIRT1-595HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human SIRT1 lysate
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Cat.#:Kit-2024Tag:
Source (Host):Species:
Product nameSIRT1 Direct Fluorescent Screening Assay Kit
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Cat.#:Kit-2025Tag:
Source (Host):Species:
Product nameSIRT1 FRET-Based Screening Assay Kit
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Cat.#:Kit-2156Tag:
Source (Host):Species:
Product nameSIRT1 Inhibitor/Activator Screening Kit
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Involved Pathway

SIRT1 involved in several pathways and played different roles in them. We selected most pathways SIRT1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
FoxO signaling pathway
CDKN1BB; USP7; PRKAG2; MAPK11; TGFBR1A; MAP2K2B; PRKAG3; PIK3R3A; GABARAPA; IRS1
AMPK signaling pathway
PFKM; RAB2A; LEPR; PRKAB1; ADIPOR2; IRS1; ADIPOQ; AKT1S1; PPP2R5E; G6PC
Glucagon signaling pathway
PPARA; FOXO1; PPP3R1; PRKAA2; G6PC; SMEK1; ATF4; LDHB; PHKB; FBP1
Amphetamine addiction
ATF2; CALML3; ARC; JUN; GRIA1; SLC6A3; SLC18A1; CAMK2A; CALM2; GRIA4
MicroRNAs in cancer
TPM1; ABCB1A; PLCG1; SERPINB5; CCNG1; PIK3CA; BRCA1; KRAS; EZR; NOTCH1

Protein Function

SIRT1 has several biochemical functions, for example, HLH domain binding, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT1 itself. We selected most functions SIRT1 had, and list some proteins which have the same functions with SIRT1. You can find most of the proteins on our site.
Function
Related Protein
Function HLH domain binding
Related Protein SIRT1; UBE2I; PKD2
Function NOT NAD+ ADP-ribosyltransferase activity
Related Protein SIRT2; SIRT1; SIRT3; SIRT5
Function NAD+ binding
Related Protein SIRT6; ALDH1A3; SIRT4; SIRT3; SIRT5; SIRT7; SIRT2; SIRT1; GLUD1; UXS1
Function NAD-dependent histone deacetylase activity
Related Protein SIRT1; SIRT6; SIRT2
Function NAD-dependent histone deacetylase activity (H3-K9 specific)
Related Protein SIRT6; SIRT1
Function NAD-dependent protein deacetylase activity
Related Protein SIRT2; SIRT1
Function bHLH transcription factor binding
Related Protein TCF3; SP1; IKZF4; TCF4; USF2; SOX9; TCF12; MAP3K10; RUNX2; FOXH1
Function core promoter sequence-specific DNA binding
Related Protein MLL1; NR1D2; PDX1; ZFHX3; NR4A3; KLF10; TRP53; SP1; TP53; SOX4
Function deacetylase activity
Related Protein MAPK1IP1L; HDAC1; NDST4; AADAC; HDAC2; MACROD2; NDST3; NDST1; MACROD1; SIRT1
Function enzyme binding
Related Protein TAL1; HDAC1; TSPAN5; HMGA1; PICK1; APP; CYP2A4; ARRB2; HIST1H2AG; PEBP1
Function histone binding
Related Protein CHD2; HIST1H4N; COPRS; RNF168; UHRF1; HAT1; DAXX; CTSL1; HIST1H3E; PHF21A
Function histone deacetylase activity
Related Protein HDAC3; HDAC5; HDAC9B; HDAC8; NACC2; SIRT2; ATXN3L; MTA2; HDAC10; HDAC4
Function identical protein binding
Related Protein UBE4A; MNS1; DNM1; MSANTD3; AIM2; CLDN15; CUBN; ALK; EWSR1; SH3GLB1
Function keratin filament binding
Related Protein SIRT1; KRT14; VIM
Function metal ion binding
Related Protein ATP13A1; CLIP1; SPON2; ACAP3; BCL11AB; EBF3A; ESRRGA; ZFP746; ITGAX; ZDHHC3B
Function mitogen-activated protein kinase binding
Related Protein TNIP1; MICALCL; NBR1; TPR; EP300; ACE; MAPKAPK2B; DUSP2; PLCB4; ARRB2
Function nuclear hormone receptor binding
Related Protein CTNNB1; HIF1A; MED1; CRY1; NCOA2; NCOR1; TACC2; ACTN4; TCF7L2; SIRT1
Function p53 binding
Related Protein MAPKAPK5; KDM1A; RNF34; RFFL; MDM2; TP53BP1; TP73; BRD4; ZMAT3; EHMT2
Function protein C-terminus binding
Related Protein SIRT1; SIAH1; MED12; OPRL1; PIAS3; PLEKHB1; ERCC2; YAP1; ECM1; DGKZ
Function protein binding
Related Protein TUBA3D; DHRS2; CHRDL2; ITGAM; OCLN; RARB; AHNAK; VHLL; EPHB6; IARS
Function protein deacetylase activity
Related Protein SIRT2; HDAC5; HDAC9; SIRT1; HDAC10; SIN3A; HDAC2; HDAC4; HDAC1; HDAC3
Function transcription corepressor activity
Related Protein KCTD1; CDX2; SKOR1B; RARA; YY1; HDAC7; CRYM; NCOR2; YAF2; BRD7
Function transcription factor binding
Related Protein HTT; PPP1R13BB; NFATC4; IFI203; EGR1; BRD7; IRF4; PPID; GTF2A2; DIP2A

Interacting Protein

SIRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT1.
TP53; WRN

SIRT1 Related Articles

Al-Bahrani, R; Tuertcher, D; et al. Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:3-9(2015).
Yeung, F; Ramsey, CS; et al. Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases. ONCOGENE 34:798-804(2015).