SIRT1 Protein, sirtuin 1


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Official Full Name sirtuin 1
Background This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Synonyms SIRT1; sirtuin 1; SIR2L1; NAD-dependent protein deacetylase sirtuin-1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1; regulatory protein SIR2 homolog 1; NAD-dependent deacetylase sirtuin-1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse SIRT1-101M Recombinant Mouse SIRT1 protein, His-tagged E.coli His
    Human SIRT1-30H Recombinant Human SIRT1 Protein, GST-tagged E.coli GST
    Human SIRT1-1165H Recombinant Human SIRT1, His tagged E.coli His
    Human SIRT1-11H Recombinant Human SIRT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SIRT1-132H Recombinant Human SIRT1, His-tagged E.coli His
    Human SIRT1-1360H Recombinant Human SIRT1 (Active), His-tagged Sf9 Insect Cell His
    Human SIRT1-190H Recombinant Human SIRT1 Protein, His-tagged E.coli His
    Human SIRT1-30565TH Recombinant Human SIRT1 E.coli N/A
    Human SIRT1-31404TH Recombinant Human SIRT1, His-tagged E.coli His
    Human SIRT1-462H Recombinant Human SIRT1, GST-tagged E.coli GST
    Human SIRT1-463H Recombinant Human SIRT1, His-tagged E.coli His
    Human SIRT1-4873H Recombinant Human Sirtuin 1, His-tagged Sf9 Insect Cell His
    Human SIRT1-4874H Recombinant Human Sirtuin 1, GST-tagged E.coli GST
    Human SIRT1-595HCL Recombinant Human SIRT1 lysate HEK293 N/A
    Human SIRT1-658H Recombinant Human SIRT1, His-tagged E.coli His
    Human SIRT1-698H Recombinant Human SIRT1 Mammalian Cell His
    Mouse SIRT1-100M Recombinant Mouse SIRT1 Protein, His-tagged E.coli His
    Rat Sirt1-1374R Recombinant Rat Sirt1 protein, His-tagged E.coli His
    Chicken SIRT1-1238C Recombinant Chicken SIRT1 Mammalian Cell His
    Kit-2024 SIRT1 Direct Fluorescent Screening Assay Kit N/A
    Kit-2025 SIRT1 FRET-Based Screening Assay Kit N/A
    Kit-2156 SIRT1 Inhibitor/Activator Screening Kit N/A

    SIRT1 involved in several pathways and played different roles in them. We selected most pathways SIRT1 participated on our site, such as FoxO signaling pathway, AMPK signaling pathway, Glucagon signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    FoxO signaling pathway NLK2; NLK1; CCND1; Fasl; PRKAG3B; CCNB3; MAP2K2B; GADD45B; SLC2A4; SGK2
    AMPK signaling pathway PPP2R2D; INS; ACACB; CPT1B; PPP2R5E; PPP2R3C; STK11; RAB2A; PPP2R5B; EEF2
    Glucagon signaling pathway PHKG1; LDHA; PRKACB; LDHAL6B; PRKAA2; PPP3CB; GCGR; LDHB; CALM2; PRKAG3
    Amphetamine addiction FOS; GRIN3A; GRIN1; CALM1; CALM3; CAMK4; GRIN2B; CREB3L3; GRIN3B; CAMK2B
    MicroRNAs in cancer EZH2; UBE2I; HMGA2; CDC25A; GLS2; TTC6; RASSF1; TRIM71; SOS1; TNXB

    SIRT1 has several biochemical functions, for example, HLH domain binding, NOT NAD+ ADP-ribosyltransferase activity, NAD+ binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT1 itself. We selected most functions SIRT1 had, and list some proteins which have the same functions with SIRT1. You can find most of the proteins on our site.

    Function Related Protein
    HLH domain binding UBE2I; PKD2; SIRT1
    NOT NAD+ ADP-ribosyltransferase activity SIRT3; SIRT2; SIRT1; SIRT5
    NAD-dependent histone deacetylase activity SIRT1; SIRT2; SIRT6
    NAD-dependent histone deacetylase activity (H3-K9 specific) SIRT6; SIRT1
    NAD-dependent protein deacetylase activity SIRT1; SIRT2
    bHLH transcription factor binding SIRT1; TCF4; MAP3K10; LMO2; SP1; USF2; SOX9; TCF12; RUNX2; TCF3A
    core promoter sequence-specific DNA binding CHD2; MEOX1; SOX9; PPARG; NR1D2; PROX1; NRIP1; ZFHX3; SOX1; H2AFY
    deacetylase activity SIRT1; C6orf130; HDAC1; MACROD2; MAPK1IP1L; MACROD1; NDST1; HDAC2; NDST3; AADAC
    enzyme binding LAMB1; TH; PICK1; CTNNB1; NOTCH3; ESR1; ITGB3; PDCD2; BRCA1; PTPLAD2
    histone binding SIRT1; HJURP; HIST1H3I; NOC2L; RAG1; L3MBTL2; NPM2; SNCA; HIST1H3C; HIST1H4M
    histone deacetylase activity MTA2; NACC2; HDAC4; SIRT2; HDAC3; HDAC8; HDAC1; HDAC9; HDAC2; HDAC9B
    identical protein binding ATXN10; USP2; PRNP; RELA; SHANK1; GOT1L1; CCL3; PYDC3; DAPK2; G6PD
    keratin filament binding VIM; SIRT1; KRT14
    metal ion binding ZC4H2; ZMYND10; ATP13A4; GFI1AB; ZNF444; PPP4CA; CTDSPL; MORC2A; NRXN3B; HBBE1.1
    mitogen-activated protein kinase binding TPR; MAPKAPK2B; NBR1; MAPKAPK2; TNIP1; CDK5RAP3; MAPKAPK2A; EP300; ARRB2; ATF7
    nuclear hormone receptor binding EP300; HIF1A; SNW1; BUD31; MYOD1; SIRT1; ACTN4; TACC2; TCF7L2; NCOA1
    p53 binding TAF9; HSPD1; TRP53; PTTG1IP; GATA1; TRIAP1; BLM; SETD8; SMARCB1; TP73
    protein C-terminus binding ERCC3; TJP2; TCF4; PHB; VTA1; ERBB2; NCF2; CALCOCO1; NEIL1; CD2AP
    protein binding CETN2; ELMO1; GLYCTK; GNB1B; RPL12; FHL1; POGK; ATP1B2; ZNF624; DAB2
    protein deacetylase activity HDAC5; HDAC4; HDAC2; HDAC9; HDAC1; SIN3A; SIRT2; HDAC10; HDAC3; SIRT1
    transcription corepressor activity RCOR2; CTCF; NR2F2; RYBP; BHLHE40; YWHAB; SSX2; SF1; E2F8; SETD8
    transcription factor binding UBN1; TP73; FOXO4; PSMC5; FOXA3; PPRC1; FLNA; GATA4; KEAP1; HIF1A

    SIRT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT1.

    TP53; WRN

    Al-Bahrani, R; Tuertcher, D; et al. Differential SIRT1 Expression in Hepatocellular Carcinomas and Cholangiocarcinoma of the Liver. ANNALS OF CLINICAL AND LABORATORY SCIENCE 45:3-9(2015).
    Yeung, F; Ramsey, CS; et al. Regulation of the mitogen-activated protein kinase kinase (MEK)-1 by NAD(+)-dependent deacetylases. ONCOGENE 34:798-804(2015).

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