| Description : |
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
81.5 kDa |
| AA Sequence : |
MADEAALALQPGGSPSAAGADREAA SSPAGEPLRKRPRRDGPGLERSPGE PGGAAPEREVPAAARGCPGAAAAAL WREAEAEAAAAGGEQEAQATAAAGE GDNGPGLQGPSREPPLADNLYDEDD DDEGEEEEEAAAAAIGYRDNLLFGD EIITNGFHSCESDEEDRASHASSSD WTPRPRIGPYTFVQQHLMIGTDPRT ILKDLLPETIPPPELDDMTLWQIVI NILSEPPKRKKRKDINTIEDAVKLL QECKKIIVLTGAGVSVSCGIPDFRS RDGIYARLAVDFPDLPDPQAMFDIE YFRKDPRPFFKFAKEIYPGQFQPSL CHKFIALSDKEGKLLRNYTQNIDTL EQVAGIQRIIQCHGSFATASCLICK YKVDCEAVRGDIFNQVVPRCPRCPA DEPLAIMKPEIVFFGENLPEQFHRA MKYDKDEVDLLIVIGSSLKVRPVAL IPSSIPHEVPQILINREPLPHLHFD VELLGDCDVIINELCHRLGGEYAKL CCNPVKLSEITEKPPRTQKELAYLS ELPPTPLHVSEDSSSPERTSPPDSS VIVTLLDQAAKSNDDLDVSESKGCM EEKPQEVQTSRNVESIAEQMENPDL KNVGSSTGEKNERTSVAGTVRKCWP NRVAKEQISRRLDGNQYLFLPPNRY IFHGAEVYSDSEDDVLSSSSCGSNS DSGTCQSPSLEEPMEDESEIEEFYN GLEDEPDVPERAGGAGFGTDGDDQE AINEAISVKQEVTDMNYPSNKSTRT RPLEQKLISEEDLAANDILDYKDDD DKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
