sox2
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  • Official Full Name
  • SRY (sex determining region Y)-box 2
  • Background
  • This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]
  • Synonyms
  • SOX2; SRY (sex determining region Y)-box 2; ANOP3; MCOPS3; transcription factor SOX-2; transcription factor SOX2; SRY-related HMG-box gene 2;
Cat.#:SOX2-3629HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOX2
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Cat.#:SOX2-2049HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRY (Sex Determining Region Y)-Box 2, His-tagged
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Cat.#:SOX2-562HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SOX2 protein, MYC/DDK-tagged
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Cat.#:SOX2-608HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOX2 Protein, His-tagged
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Cat.#:SOX2-667HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOX2, His-tagged
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Cat.#:SOX2-67HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOX2 protein
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Cat.#:SOX2-15780MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SOX2 Protein
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Cat.#:Sox2-193MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sox2, His-tagged
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Cat.#:SOX2-4413RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SOX2 Protein, His-tagged
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Cat.#:SOX2-6743CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SOX2
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Cat.#:SOX2-12337ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SOX2
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Cat.#:SOX2-1561HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SOX2 293 Cell Lysate
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Cat.#:Kit-2289Tag:
Source (Host):Species:
Product nameSOX2 (Human) Transcription Factor Activity Assay Kit
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Involved Pathway

SOX2 involved in several pathways and played different roles in them. We selected most pathways SOX2 participated on our site, such as Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Hippo signaling pathway
WNT9A; ID2; STK3; TEAD2; YWHAZ; CDH1; TEAD3; GLI2; BMPR2; PRKCI
Signaling pathways regulating pluripotency of stem cells
WNT3A; WNT2B; MAPK1; STAT3; PIK3CG; MEIS1; WNT8B; WNT10B; ESX1; AXIN2

Protein Function

SOX2 has several biochemical functions, for example, DNA binding, miRNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX2 itself. We selected most functions SOX2 had, and list some proteins which have the same functions with SOX2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein KLF14; HMBOX1; TIGD3; ZBTB16; ARX; HIST1H4F; CASZ1; GATA4; WDHD1; ZBTB43
Function miRNA binding
Related Protein MEF2C; POU5F1; PNPT1; TRIM71; AGO4; TARBP2; SOX2; LIN28A; AGO1; AGO2
Function protein binding
Related Protein RAET1D; GJB6; LEPROT; TBRG1; MSI2; ADRB2; ARHGEF15; FAM164A; SH2D4A; ITGB4
Function sequence-specific DNA binding
Related Protein SOX14; LHX1A; DMBX1A; FOXN1; MKXB; MIXL1; ZBTB14; CEBPD; HLFB; IRX4B
Function transcription factor activity, sequence-specific DNA binding
Related Protein AHR1A; POU2F1B; PBX1A; ZNF549; RORCA; LMX1B; MESPBA; DMRT1; POU6F1; BATF
Function transcription regulatory region DNA binding
Related Protein ZNF335; TAF9; CDK9; NKX3; RFX6; H2AFY; TBL1X; ARRB1; CCNT1; DLX5
Function transcription regulatory region sequence-specific DNA binding
Related Protein BTBD8; CREB3L3; NFKB1; NFE2L1A; NR5A1; TFAP2A; ATF3; HDAC1; FOXJ1; NKX3
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein E2F4; MYB; FOXD1; SP1; FOXA1; PLSCR1; TCF21; MYOCD; SPI1; RFX4

Interacting Protein

SOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX2.
SUMO1; PRKCI; POU5F1; SALL2; CASP8; hhat_human_gene; gli2_human_gene; jag1_human_gene; gli3_human_gene; mycn_human_gene; necd_human_gene

SOX2 Related Articles

Tyagi, D; Perez, JB; et al. Detection of embryonic stem cell lysate biomarkers by surface plasmon resonance with reduced nonspecific adsorption. ANALYTICAL BIOCHEMISTRY 471:29-37(2015).
Ginisty, A; Gely-Pernot, A; et al. Evidence for a Subventricular Zone Neural Stem Cell Phagocytic Activity Stimulated by the Vitamin K-Dependent Factor Protein S. STEM CELLS 33:515-525(2015).