stat2
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  • Official Full Name
  • signal transducer and activator of transcription 2, 113kDa
  • Background
  • STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. Stat2 (113 kDa), originally purified from the nuclei of alpha-interferon-treated cells,Is critical to the transcriptional responses induced by type I interferons,ifN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by ifN-alpha/beta via assocations with receptor-bound Jak kinases.
  • Synonyms
  • STAT2; signal transducer and activator of transcription 2, 113kDa; signal transducer and activator of transcription 2, 113kD; signal transducer and activator of transcription 2; STAT113; interferon alpha induced transcriptional activator; P113; ISGF-3; MGC59816
Cat.#:STAT2-2997HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT2, GST-tagged
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Cat.#:STAT2-30904THTag:
Source (Host):Species:Human
Product nameRecombinant Human STAT2
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Cat.#:STAT2-332HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT2 protein, His/MBP-tagged
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Cat.#:STAT2-333HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT2 protein, His/MBP-tagged
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Cat.#:STAT2-334HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT2 protein, His/MBP-tagged
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Cat.#:STAT2-7056HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STAT2, GST-tagged
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Cat.#:STAT2-8474HTag:His
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human STAT2, His-tagged
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Cat.#:Stat2-1809MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Stat2 protein, His & T7-tagged
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Cat.#:Stat2-1810RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Stat2 protein, His & T7-tagged
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Cat.#:STAT2-4517RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey STAT2 Protein, His-tagged
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Cat.#:STAT2-8272ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STAT2
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Cat.#:STAT2-2515HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human STAT2, His-tagged
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Cat.#:STAT2-1419HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human STAT2 293 Cell Lysate
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Involved Pathway

STAT2 involved in several pathways and played different roles in them. We selected most pathways STAT2 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
VAV2; CDC42; Ccl27a; CXCL2; FOXO3; CXCL6; CCL4L1; PPBP; PIK3R5; GNG11
Osteoclast differentiation
FOS; PPP3R1; MITF; FCGR4; FCGR2B; CYLD; PIK3R1; TYK2; NCF2; IFNG
Jak-STAT signaling pathway
TSLP; IL12B; IFNA12; GH1; CSF3R; JAK2B; PTPN11A; GM2002; PIAS4; PIM1
Hepatitis C
CLDN2; TRAF2; PDPK1; OAS3; IKBKB; IFNA10; CLDN20; Ifna11; OAS2; PPP2R2C
Hepatitis B
STAT5B; SMAD3; HBXIP; STAT2; RELA; NRAS; IKBKE; IFNA4; PRKCA; CCNE1
Measles
PRKCQ; TNFAIP3; IRAK1; TBK1; GSK3B; STAT2; CCND2; PIK3CD; MAVS; PIK3CB
Influenza A
PIK3R3; TNFRSF10B; NXT1; TLR3; IFNB; AKT1; MAP2K2; PML; TNFRSF10C; EIF2AK3
Herpes simplex infection
CUL1A; HLA-DRB4; MHC2DAB; RNASEL; IFNA4; CD74; HCFC1A; JAK2B; OAS1; TAF5

Protein Function

STAT2 has several biochemical functions, for example, DNA binding, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT2 itself. We selected most functions STAT2 had, and list some proteins which have the same functions with STAT2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein EN1; PPARD; GATA4; POLR3C; EME2; HIST1H4A; POLDIP2; HOXA13A; SETDB1A; ZNF565
Function identical protein binding
Related Protein MCM6; NFKB1; SYNE1; DYNLRB1; GPR50; CNTN2; MRAP2; DAPK2; MUL1; NCL
Function protein binding
Related Protein MYLK2; ESRRA; TAL2; VEGFAB; ZNF131; PTPRG; DDX17; CACNA1SB; LDHB; GRASP
Function signal transducer activity
Related Protein MUL1A; GNA11; TAAR12F; EDNRBA; MTNR1BA; PLCD3A; GNG12; MRGPRH; MTNR1C; MAPKAPK2B
Function transcription factor activity, sequence-specific DNA binding
Related Protein STAT5B; LHX1; STAT4; RAB11FIP4A; FOSL1; ZNF773; HES6; ESR2; INSM1B; ELK3

Interacting Protein

STAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT2.
STAT1; IFNAR1; IRF9

STAT2 Related Gene Family

Cytokines