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TNFRSF8

  • Official Full Name

    Tumor Necrosis Factor Receptor Superfamily, Member 8

  • Overview

    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Synonyms

    CD 30; CD153 antibodyCD30; CD30 antigen; CD30L receptor; Cytokine receptor CD30; D1S166E; KI 1; Ki-1 antigen; KI1; Lymphocyte activation; antigen CD30; TNFRSF8; Tumor Necrosis Factor Receptor Superfamily Member 8; Iratumumab; 640735-09-7; 914088-09-8; CD30; Ki-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • Insect Cell
  • Insect cells
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • 6×His
  • 6His
  • Avi
  • hFc
  • His
  • DDK
  • Fc
  • Fc|His
  • hIgG
  • hIgG1
  • hIgG4
  • His (Fc)
  • His\Avi
  • His|Avi
  • LIgG2b Fc
  • mFc
  • Myc
  • Myc|DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TNFRSF8-1821H Active Recombinant Human TNFRSF8 protein, His & Avi-tagged, Biotinylated HEK293 His/Avi AA Phe 19 - Lys 379
Human TNFRSF8-051H Active Recombinant Human TNFRSF8 protein, His/Avi-tagged, Biotinylated HEK293 cells His/Avi Phe19-Lys379
Human TNFRSF8-263HAF555 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Human TNFRSF8-263HAF488 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Human TNFRSF8-973H Active Recombinant Human TNFRSF8 Protein, His & hFc-tagged HEK293 His & hFc Met 1-Lys 379
Human TNFRSF8-052H Active Recombinant Human TNFRSF8 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Phe19-Lys379
Human TNFRSF8-1594HAF647 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Human TNFRSF8-263HAF647 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Human TNFRSF8-1594HF Active Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Human TNFRSF8-1594HAF488 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Human TNFRSF8-263HF Active Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Human TNFRSF8-1594HAF555 Active Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Human TNFRSF8-642HP Recombinant Human TNFRSF8 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Human TNFRSF8-563H Recombinant Human TNFRSF8, His tagged Human Cell His
Human TNFRSF8-26927TH Recombinant Human TNFRSF8 Wheat Germ N/A 113 amino acids
Human TNFRSF8-642H Recombinant Human TNFRSF8, Fc-His tagged Human Cell Fc/His
Human TNFRSF8-1594H Recombinant Human TNFRSF8, Fc-tagged Mammalian cells Fc
Human TNFRSF8-7532H Recombinant Human TNFRSF8, His-tagged E.coli His 19-379aa
Human TNFRSF8-641H Recombinant Human TNFRSF8 Protein, Fc-tagged HEK293 Fc Phe 19 - Lys 379
Human TNFRSF8-377H Recombinant Human TNFRSF8 Protein, His-tagged Insect Cell His
Human TNFRSF8-889H Recombinant Human TNFRSF8 Protein, DDK-tagged Sf9 Insect Cell DDK
Human TNFRSF8-2097HCL Recombinant Human TNFRSF8 cell lysate Human Cell N/A
Human TNFRSF8-641HAF488 Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc Phe 19-Lys 379
Human TNFRSF8-563HAF647 Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 372
Human TNFRSF8-641HA Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled HEK293 Fc Met1-Lys379
Human TNFRSF8-451H Recombinant Human TNFRSF8 Protein, His-tagged E.coli N-His Met464-Lys595
Human TNFRSF8-2027H Recombinant Human TNFRSF8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human TNFRSF8-444H Recombinant Human TNFRSF8 Protein, His-Avi-tagged HEK293 His-Avi Phe19-Lys379
Human TNFRSF8-642HA Recombinant Human TNFRSF8 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Human TNFRSF8-08H Recombinant Human TNFRSF8 Protein, C-6His-Avi tagged, Biotinylated Human Cell C-6His-Avi Gln24-Lys265(Met115Thr)
Human TNFRSF8-1594HA Recombinant Human TNFRSF8 protein, Fc-tagged, APC labeled Mammalian cells Fc
Human TNFRSF8-563HAF488 Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 372
Human TNFRSF8-641HAF555 Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc Phe 19-Lys 379
Human TNFRSF8-150H Recombinant Human TNFRSF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human TNFRSF8-434H Recombinant Human TNFRSF8 Protein (Met1-Lys379), His-tagged, Biotinylated HEK293 His Met1-Lys379
Human TNFRSF8-642HAF488 Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 609
Human TNFRSF8-642HAF555 Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 609
Human TNFRSF8-0270H Recombinant Human TNFRSF8 protein, His&Avi-tagged, Biotinylated HEK293 His&Avi Met1-Lys379
Human TNFRSF8-908H Recombinant Human TNFRSF8 protein, mFc-tagged HEK293 mFc Phe19-Lys379
Human TNFRSF8-563HF Recombinant Human TNFRSF8 Protein, His-tagged, FITC conjugated HEK293 His 372
Human TNFRSF8-641HAF647 Recombinant Human TNFRSF8 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc Phe 19-Lys 379
Human TNFRSF8-2031H Recombinant Human TNFRSF8 Protein, DDK-tagged Insect Cell DDK
Human TNFRSF8-567HG Active GMP Recombinant Human TNFRSF8 protein HEK293 DNA sequence encoding Human CD30(UniProtKB - P28908 ) was expressed with His tag at the C-terminal.
Human TNFRSF8-180H Recombinant Human TNFRSF8 Protein, His\Avi-tagged Human Cell His\Avi
Human TNFRSF8-642HAF647 Recombinant Human TNFRSF8 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 609
Human TNFRSF8-1594HP Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled HEK293 Fc Met1-Lys379
Human TNFRSF8-2788H Recombinant Human TNFRSF8 protein, His-tagged E.coli His 19-246 aa
Human TNFRSF8-145H Recombinant Human TNFRSF8 Protein, His-tagged HEK293 His 595
Human TNFRSF8-642HF Recombinant Human TNFRSF8 Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 609
Human TNFRSF8-641HP Recombinant Human TNFRSF8 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human TNFRSF8-563HAF555 Recombinant Human TNFRSF8 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 372
Human TNFRSF8-150H-B Recombinant Human TNFRSF8 Protein Pre-coupled Magnetic Beads HEK293
Human TNFRSF8-2637H Active Recombinant Human TNFRSF8 protein, His-tagged HEK293 His Phe19-Lys379
Human TNFRSF8-373H Active Recombinant Human TNFRSF8 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 LIgG2b Fc Phe 19 - Lys 379
Human TNFRSF8-146H Recombinant Human TNFRSF8 Protein, Fc-tagged HEK293 Fc 595
Human TNFRSF8-4659H Active Recombinant Human TNFRSF8 Protein, His-tagged, PE-Labeled HEK293 His Phe 19 - Lys 379
Human TNFRSF8-561H Recombinant Human TNFRSF8 Protein (Phe19-Lys379), C-6×His-tagged HEK293 C-6×His Phe19-Lys379
Human Tnfrsf8-058M Recombinant Mouse Tnfrsf8 Protein, hFc-tagged HEK293 hFc Met1-Thr258
Human TNFRSF8-641HF Recombinant Human TNFRSF8 Protein, Fc-tagged, FITC conjugated HEK293 Fc Phe 19-Lys 379
Human TNFRSF8-0272H Recombinant Human TNFRSF8 protein, His-tagged, Biotinylated HEK293 His Met1-Lys379
Human TNFRSF8-5335H Recombinant Human TNFRSF8 Protein (Met1-Lys379), C-His tagged Mammalian cells C-His Met1-Lys379
Mouse Tnfrsf8-1713M Recombinant Mouse Tnfrsf8 Mammalian cells N/A
Mouse Tnfrsf8-10625M-B Recombinant Mouse Tnfrsf8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Tnfrsf8-10625M Recombinant Mouse Tnfrsf8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Tnfrsf8-038M Recombinant Mouse Tnfrsf8 Protein, hIgG/His-tagged Insect cells hIgG/His
Mouse TNFRSF8-1155M Recombinant Mouse TNFRSF8 Protein (Met1-Thr258), His-tagged HEK293 His Met1-Thr258
Mouse TNFRSF8-1156M Recombinant Mouse TNFRSF8 protein(Met1-Thr258), hFc-tagged HEK293 C-hFc Met1-Thr258
Mouse Tnfrsf8-006M Recombinant Mouse Tnfrsf8 Protein, hIgG/His-tagged Insect Cells hIgG/His 19-258aa
Mouse Tnfrsf8-6549M Recombinant Mouse Tnfrsf8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat TNFRSF8-6201R Recombinant Rat TNFRSF8 Protein Mammalian Cell His
Rat TNFRSF8-5858R Recombinant Rat TNFRSF8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat TNFRSF8-5858R-B Recombinant Rat TNFRSF8 Protein Pre-coupled Magnetic Beads HEK293
Rat Tnfrsf8-452R Recombinant Rat Tnfrsf8 Protein, His&GST-tagged E.coli N-His&GST Asn43-Leu201
Rhesus monkey TNFRSF8-1720R Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey TNFRSF8-1691R Recombinant Rhesus Monkey TNFRSF8 Protein HEK293 N/A
Rhesus monkey TNFRSF8-1721R Recombinant Rhesus Monkey TNFRSF8 Protein, hIgG4-tagged HEK293 hIgG4
Cynomolgus TNFRSF8-045C Recombinant Cynomolgus TNFRSF8 protein, His-tagged HEK293 His Met1-Gly194
Homo sapiens (Human) RFL31646HF Recombinant Full Length Human Tumor Necrosis Factor Receptor Superfamily Member 8(Tnfrsf8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-595)
Rattus norvegicus (Rat) RFL12946RF Recombinant Full Length Rat Tumor Necrosis Factor Receptor Superfamily Member 8(Tnfrsf8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (19-493)
Chicken TNFRSF8-6014C Recombinant Chicken TNFRSF8 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TNFRSF8 Related Articles
  • TNFRSF8 Related Research Area
  • TNFRSF8 Related Signal Pathway

TNFRSF8 involved in several pathways and played different roles in them. We selected most pathways TNFRSF8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCSF1RA;CXCL2;IL19;CCR10;LOC100033925;Il23a;BMPR1A;CRLF2;Il6ra

TNFRSF8 has several biochemical functions, for example, transmembrane signaling receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF8 itself. We selected most functions TNFRSF8 had, and list some proteins which have the same functions with TNFRSF8. You can find most of the proteins on our site.

Function Related Protein
transmembrane signaling receptor activityKLRD1;OR12D3;TNFRSF11A;M6PR;TLR5;FZD7A;CD79B;EGFR;CELSR3
tumor necrosis factor-activated receptor activityTNFRSFA;TNFRSF1A;TNFRSF9A;NGFRB;TNFRSF25;EDA2R;CD40;TNFRSF1B;HDR

TNFRSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF8.

Traf1; Traf2; BCL6

Slack, GW; Steidl, C; et al. CD30 expression in de novo diffuse large B-cell lymphoma: a population-based study from British Columbia. BRITISH JOURNAL OF HAEMATOLOGY 167:608-617(2014).
Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).
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