tnfrsf8
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  • Official Full Name
  • Tumor Necrosis Factor Receptor Superfamily, Member 8
  • Background
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
  • Synonyms
  • CD 30; CD153 antibodyCD30; CD30 antigen; CD30L receptor; Cytokine receptor CD30; D1S166E; KI 1; Ki-1 antigen; KI1; Lymphocyte activation; antigen CD30; TNFRSF8; Tumor Necrosis Factor Receptor Superfamily Member 8; Iratumumab; 640735-09-7; Brentuximab vedotin; 914088-09-8; CD30; Ki-1
Cat.#:TNFRSF8-2027HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF8 Protein, MYC/DDK-tagged
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Cat.#:TNFRSF8-2031HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human TNFRSF8 Protein, DDK-tagged
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Cat.#:TNFRSF8-1594HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human TNFRSF8, Fc-tagged
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Cat.#:TNFRSF8-1821HTag:His/AVI
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF8 protein, His & Avi-tagged, Biotinylated
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Cat.#:TNFRSF8-263HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human TNFRSF8, Fc Chimera
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Cat.#:TNFRSF8-26927THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TNFRSF8
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Cat.#:TNFRSF8-377HTag:His
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TNFRSF8 Protein, His-tagged
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Cat.#:TNFRSF8-563HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF8, His tagged
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Cat.#:TNFRSF8-641HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF8 Protein, Fc-tagged
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Cat.#:TNFRSF8-642HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF8, Fc-His tagged
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Cat.#:TNFRSF8-7532HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TNFRSF8, His-tagged
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Cat.#:TNFRSF8-889HTag:DDK
Source (Host):sf9 cellsSpecies:Human
Product nameRecombinant Human TNFRSF8 Protein, DDK-tagged
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Cat.#:Tnfrsf8-1713MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Tnfrsf8
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Cat.#:TNFRSF8-6201RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TNFRSF8 Protein
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Cat.#:TNFRSF8-1691RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF8 Protein
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Cat.#:TNFRSF8-1720RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF8 Protein, hIgG1-tagged
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Cat.#:TNFRSF8-1721RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey TNFRSF8 Protein, hIgG4-tagged
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Cat.#:TNFRSF8-6014CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken TNFRSF8
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Cat.#:TNFRSF8-2097HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human TNFRSF8 cell lysate
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Cat.#:CSC-P0125Tag:
Source (Host):Species:
Product nameAnti-Human CD30 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0126Tag:
Source (Host):Species:
Product nameAnti-Human CD30 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0127Tag:
Source (Host):Species:
Product nameAnti-Human CD30 scFv Stable Cell Line-CHO
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Cat.#:CSC-P0332Tag:
Source (Host):Species:
Product nameAnti-Human CD30 MAb Stable Cell Line-CHO
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Cat.#:CSC-P0333Tag:
Source (Host):Species:
Product nameAnti-Human CD30 F(ab) Stable Cell Line-CHO
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Cat.#:CSC-P0334Tag:
Source (Host):Species:
Product nameAnti-Human CD30 scFv Stable Cell Line-CHO
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Involved Pathway

TNFRSF8 involved in several pathways and played different roles in them. We selected most pathways TNFRSF8 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF8 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
FIGF; IFNA14; PDGFA; IFNPHI1; CD40LG; HGF; TNFRSF1B; CSF2RB; IL18; PPBP

Protein Function

TNFRSF8 has several biochemical functions, for example, transmembrane signaling receptor activity, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF8 itself. We selected most functions TNFRSF8 had, and list some proteins which have the same functions with TNFRSF8. You can find most of the proteins on our site.
Function
Related Protein
Function transmembrane signaling receptor activity
Related Protein MPL; TLR4; CELSR1; OR103-4; MRC1; Fzd4; FCGR2C; FZD7A; EBP; FZD3A
Function tumor necrosis factor-activated receptor activity
Related Protein TNFRSF9; TNFRSF1A; CD40; TNFRSF21; HDR; TNFRSF18; TNFRSF10B; TNFRSF8; LTBR; FAS

Interacting Protein

TNFRSF8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF8 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF8.
Traf1; Traf2; BCL6

TNFRSF8 Related Articles

Slack, GW; Steidl, C; et al. CD30 expression in de novo diffuse large B-cell lymphoma: a population-based study from British Columbia. BRITISH JOURNAL OF HAEMATOLOGY 167:608-617(2014).
Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).