tyk2
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  • Official Full Name
  • tyrosine kinase 2
  • Background
  • This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TYK2; tyrosine kinase 2; JTK1; non-receptor tyrosine-protein kinase TYK2;
Cat.#:TYK2-31641THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TYK2
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Cat.#:TYK2-345HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TYK2
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Cat.#:TYK2-3508HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TYK2, His-tagged
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Cat.#:TYK2-702HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TYK2, His-tagged
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Cat.#:TYK2-89HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TYK2 protein, Flag-tagged, Biotinylated
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Cat.#:Tyk2-7156MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tyk2 protein, His & T7-tagged
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Cat.#:TYK2-1505HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TYK2 (Active), GST-tagged
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Cat.#:TYK2-1867HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TYK2 cell lysate
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Cat.#:Kit-1635Tag:
Source (Host):Species:
Product nameTYK2 Activity Assay Kit
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Involved Pathway

TYK2 involved in several pathways and played different roles in them. We selected most pathways TYK2 participated on our site, such as Osteoclast differentiation, Jak-STAT signaling pathway, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Osteoclast differentiation
IL1A; MAP3K14; STAT2; PIK3R5; NOX3; PPP3R1; FOSB; PIK3R3; TGFB2; CSF1
Jak-STAT signaling pathway
FHL1B; IL28RA; SOCS5; GM-CSF; PTPN2B; IFNA21; AKT2L; PIK3CA; GRB2B; IFNB
Toxoplasmosis
LAMC1; STAT1; HLA-DPB1; PPIF; ALOX5; PIK3CB; NOS2; HLA-DRA; H2-AB1; GNAO1
Hepatitis C
RIPK1; PIK3R3; PIK3R1; OAS1B; IRF9; TNF; CLDN1; KRAS; STAT1; EIF2AK3
Measles
EIF3H; IL13; PIK3CD; EIF2AK1; CD3E; CD3D; DDX58; FCGR2B; TRAF6; CLEC4M; MAP3K7
Influenza A
FASLG; DNAJB1; MAVS; TBK1; IFNB1; PML; IFNGR1; MAP2K2; OAS1A; SLC25A6
Herpes simplex infection
SFRS3B; C3A.1; CLOCKA; CYCSB; PVRL2; TAF6L; TRAF2; SRPK1A; IFNA5; PPP1CAB
Epstein-Barr virus infection
PRKACA; SPN; GTF2B; FGR; YWHAB; AKT1; NFKBIE; HLA-DQA2; HSPA1A; PIK3R2

Protein Function

TYK2 has several biochemical functions, for example, ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYK2 itself. We selected most functions TYK2 had, and list some proteins which have the same functions with TYK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ACTC1B; STK25B; MYO3B; PKDCCA; KIF22; CDK16; PAK4; TTBK1; ABCA7; MOV10
Function growth hormone receptor binding
Related Protein Gh; SOCS2; TYK2; GH1; JAK2; JAK1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein BTK; EIF2AK2; PTK2BB; SRC; DYRK1A; BAZ1B; FER; ZAP70; SYK; TEC
Function protein binding
Related Protein GTF2E2; PLEKHG4; RFWD2; WSB1; KLC1; TEKT4; RNF213; NAT10; TNFSF12; CAMKK1
Function protein tyrosine kinase activity
Related Protein TYRO3; MAP2K2; TTK; ZAP70; FGR; PTK2B; Fert2; FGFR3; BTK; CSK
Function type 1 angiotensin receptor binding
Related Protein ARAP1; JAK2; AGT; GNA13; GNA13A; ARRB2; GNB1; GNG3; GNA13B; BDKRB2

Interacting Protein

TYK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYK2.
KHDRBS2; FHL3; KRT40; HNRPK; TRAF4; E6; E6