tyk2
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  • Official Full Name
  • tyrosine kinase 2
  • Background
  • This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
  • Synonyms
  • TYK2; tyrosine kinase 2; JTK1; non-receptor tyrosine-protein kinase TYK2;
Cat.#:TYK2-31641THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human TYK2
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Cat.#:TYK2-345HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TYK2
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Cat.#:TYK2-3508HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TYK2, His-tagged
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Cat.#:TYK2-702HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TYK2, His-tagged
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Cat.#:TYK2-89HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human TYK2 protein, Flag-tagged, Biotinylated
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Cat.#:Tyk2-7156MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Tyk2 protein, His & T7-tagged
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Cat.#:TYK2-1505HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TYK2 (Active), GST-tagged
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Cat.#:TYK2-1867HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TYK2 cell lysate
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Cat.#:Kit-1635Tag:
Source (Host):Species:
Product nameTYK2 Activity Assay Kit
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Involved Pathway

TYK2 involved in several pathways and played different roles in them. We selected most pathways TYK2 participated on our site, such as Osteoclast differentiation, Jak-STAT signaling pathway, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Osteoclast differentiation
LILRA4; TYK2; PPP3CA; FCGR1; ITGB3; NCF1; IFNG; TGFB2; NFATC2; STAT2
Jak-STAT signaling pathway
IL6; IL7R; Ifnl2; IL22RA2; CNTF; IL-15RA; IFNL3; IL17D; NT5C3; SOCS1
Toxoplasmosis
IKBKB; ITGB1; STAT3; STAT1; NOS2; TNFRSF1A; HLA-DRB4; TAB2; LAMB3; CD40
Hepatitis C
IFNB1; MAPK11; IRF7; GRB2; PIK3R5; MAPK8; OSTN; RIPK1; IKBKE; CLDN7
Measles
IL12B; TLR2; OAS1; PIK3CA; CCND2; RELA; HSPA1B; TACR1; Ifna11; EIF3H
Influenza A
PABPN1L; TNFRSF10D; DNAJC3; IL6; HLA-DMA; CASP1; NLRX1; HLA-DQB1; PIK3CB; MAP2K1
Herpes simplex infection
HLA-DOB; IFNA10; SRSF2B; STAT2; IL6; IL12BA; BF2; CUL1A; CYCSB; SOCS3
Epstein-Barr virus infection
PSMD11; LYN; PSMC3; MAPK12; MAP3K7; ITGAL; TRP53; PSMD13; SPI1; POLR3B

Protein Function

TYK2 has several biochemical functions, for example, ATP binding, growth hormone receptor binding, non-membrane spanning protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TYK2 itself. We selected most functions TYK2 had, and list some proteins which have the same functions with TYK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein STK38A; BMX; STK35; PRKACB; TPX2; LRRK2; GSS; NAGK; PFKFB2A; NTRK2B
Function growth hormone receptor binding
Related Protein SOCS2; Gh; JAK1; TYK2; JAK2; GH1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein FER; CSK; TXK; ZAP70; Fert2; SYK; YRK; DYRK1A; SRC; STK16
Function protein binding
Related Protein PDZD7; IL1RAPL1; SPSB4; TPM1; SNRPF; PPP1R16A; PPP1R12A; SPTAN1; KLC3; TNNT1
Function protein tyrosine kinase activity
Related Protein PDGFRB; BTK; JAK1; Fert2; TNK1; INSRB; DYRK1B; PTK7; ERBB4A; Aatk
Function type 1 angiotensin receptor binding
Related Protein GNA13A; GNA13; GNA13B; GNG3; ARRB2; AGT; TYK2; JAK2; BDKRB2; ARAP1

Interacting Protein

TYK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYK2.
KHDRBS2; FHL3; KRT40; HNRPK; TRAF4; E6; E6