|Official Full Name||ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)|
|Background||The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]|
|Synonyms||UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; epididymis luminal protein 117; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
UCHL1 involved in several pathways and played different roles in them. We selected most pathways UCHL1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Parkinsons disease||SDHB; UQCR10; SLC18A1; HTRA2; LRRK2; VDAC2; NDUFB4; SLC25A31; ATP5A1; NDUFV3|
UCHL1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL1 itself. We selected most functions UCHL1 had, and list some proteins which have the same functions with UCHL1. You can find most of the proteins on our site.
|alpha-2A adrenergic receptor binding||ADRA2C; UCHL1; ADRBK1; ADRB1; APLP1|
|cysteine-type endopeptidase activity||USP51; USP50; PSD; CTSJ; USP47; USP19; MALT1; FAM49BA; USP44; MALT1A|
|ligase activity||PRPF19; KCMF1; HECTD3; RTCD1; RNF20; RNF19B; TTLL13; TTC3; CMTM2A; MEX3C|
|omega peptidase activity||ATXN3L; UCHL5; JOSD1; JOSD2; USP13; UCHL1; ATXN3; APEH; GGH; USP5|
|protein binding||RILP; GTF3C6; NLRP2; SLC52A2; RABAC1; LRPPRC; MBD3; ZNF69; ALDH18A1; DENND2D|
|ubiquitin binding||SHRPRBCK1R; BCL10; FAN1; SMAD3; BRAP; MARK4; UBR5; DNAJC2; IWS1; UCHL3|
|ubiquitin protein ligase binding||CUL5A; DTX1; PIAS2; YWHAE; HSPA8; HSPA9; PCBP2; KCNQ3; JAK1; PRDX6|
|ubiquitin-specific protease activity||USP43A; USP50; USP17L2; USP44; USP28; USP27X; OTUD4; ZRANB1; OTUB2; USP31|
UCHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL1.
COPS5; EGFR; TERF2IP; CDKN1B; NCAM1; EIF1B; KRT4; MCC; VHL; EIF6; KRT17; IKBKE; CCDC14; ATG5; USP21