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Official Full Name ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Background The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Synonyms UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; epididymis luminal protein 117; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Rabbit
    • Tag :
    • GST
    • His
    • S
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UCHL1-35H Recombinant Human UCHL1 Protein, His-tagged E. coli His
    Human CAB11621RH Rabbit Monoclonal Antibody to Human Ubiquitin Carboxyl-Terminal Esterase L1 Rabbit N/A
    Human UCHL1-1520H Recombinant Human UCHL1 Human N/A
    Human UCHL1-1637H Recombinant Human Ubiquitin Carboxyl-Terminal Esterase L1 (ubiquitin thiolesterase), His-tagged E.coli His
    Human UCHL1-181H Recombinant Human Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) E.coli N/A
    Human UCHL1-227H Recombinant Human UCHL1 protein, T7/His-tagged E.coli T7/His
    Human UCHL1-3091H Recombinant Human UCHL1, His tagged E.coli His
    Human UCHL1-392H Recombinant Human UCHL1 protein, His-tagged E.coli His
    Human UCHL1-49H Recombinant Human UCHL1, GST-tagged E.coli GST
    Human UCHL1-535HCL Recombinant Human UCHL1 293 Cell Lysate HEK293 N/A
    Human UCHL1-7026H Recombinant Human UCHL1, His-tagged E.coli His
    Mouse UCHL1-17778M Recombinant Mouse UCHL1 Protein Mammalian Cell His
    Mouse Uchl1-20M Recombinant Mouse Uchl1, His tagged E.coli His
    Mouse Uchl1-611M Recombinant Mouse Uchl1 Protein, His-tagged E.coli His
    Mouse Uchl1-69M Recombinant Mouse Uchl1, His-tagged E.coli His
    Rat Uchl1-17R Recombinant Rat Uchl1 protein, His/S-tagged E.coli His/S
    Rat Uchl1-1809R Recombinant Rat Uchl1, His tagged E.coli His
    Rat Uchl1-612R Recombinant Rat Uchl1 Protein, His-tagged E.coli His
    Rat UCHL1-6418R Recombinant Rat UCHL1 Protein Mammalian Cell His
    Chicken UCHL1-3608C Recombinant Chicken UCHL1 Mammalian Cell His
    Zebrafish UCHL1-11523Z Recombinant Zebrafish UCHL1 Mammalian Cell His

    UCHL1 involved in several pathways and played different roles in them. We selected most pathways UCHL1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Parkinsons disease SDHB; UQCR10; SLC18A1; HTRA2; LRRK2; VDAC2; NDUFB4; SLC25A31; ATP5A1; NDUFV3

    UCHL1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL1 itself. We selected most functions UCHL1 had, and list some proteins which have the same functions with UCHL1. You can find most of the proteins on our site.

    Function Related Protein
    alpha-2A adrenergic receptor binding ADRA2C; UCHL1; ADRBK1; ADRB1; APLP1
    cysteine-type endopeptidase activity USP51; USP50; PSD; CTSJ; USP47; USP19; MALT1; FAM49BA; USP44; MALT1A
    ligase activity PRPF19; KCMF1; HECTD3; RTCD1; RNF20; RNF19B; TTLL13; TTC3; CMTM2A; MEX3C
    omega peptidase activity ATXN3L; UCHL5; JOSD1; JOSD2; USP13; UCHL1; ATXN3; APEH; GGH; USP5
    protein binding RILP; GTF3C6; NLRP2; SLC52A2; RABAC1; LRPPRC; MBD3; ZNF69; ALDH18A1; DENND2D
    ubiquitin binding SHRPRBCK1R; BCL10; FAN1; SMAD3; BRAP; MARK4; UBR5; DNAJC2; IWS1; UCHL3
    ubiquitin protein ligase binding CUL5A; DTX1; PIAS2; YWHAE; HSPA8; HSPA9; PCBP2; KCNQ3; JAK1; PRDX6
    ubiquitin-specific protease activity USP43A; USP50; USP17L2; USP44; USP28; USP27X; OTUD4; ZRANB1; OTUB2; USP31

    UCHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL1.


    Zheng, S; Qiao, GL; et al. Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma. CANCER LETTERS 359:36-46(2015).
    Brackeva, B; De Punt, V; et al. Potential of UCHL1 as biomarker for destruction of pancreatic beta cells. JOURNAL OF PROTEOMICS 117:156-167(2015).

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