Wnt5a
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Official Full Name
wingless-type MMTV integration site family, member 5A
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Overview
The Wnt family includes several secreted glycoproteins that play important roles in animal development. There are 19 Wnt genes in the human genome that encode functionally distinct Wnt proteins. Wnt members bind to the Frizzled family of seven-pass transm -
Synonyms
WNT5A; wingless-type MMTV integration site family, member 5A; protein Wnt-5a; hWNT5A; WNT 5A protein; WNT-5A protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Human/Mouse
- Mouse
- Rat
- Zebrafish
- CHO
- E. coli
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- L-Wnt-5a-expressing Mouse Fibroblast
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- His|GST
- SUMO
- DDK
- Myc|DDK
- N/A
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- Wnt5a Related Articles
- Wnt5a Related Gene Family
- Wnt5a Related Research Area
- Wnt5a Related Signal Pathway
Wnt5a involved in several pathways and played different roles in them. We selected most pathways Wnt5a participated on our site, such as Wnt signaling pathway, Hedgehog signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Wnt5a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Wnt signaling pathway | WNT4A;WNT10B;WNT11;RAC3;TCF7L1A;CSNK1A1L;NFATC2;SERPINF1;TCF7 |
Hedgehog signaling pathway | WNT1;WNT5A;LRP2;ZIC2B;WNT3;BMP4;GAS1B;DHH;CSNK1G3 |
Hippo signaling pathway | JUB;TGFB2;WWTR1;BMP8A;FZD10;PPP2R2D;TEAD2;CTNNA2;FRMD6 |
Signaling pathways regulating pluripotency of stem cells | NEUROG1;PIK3R3;LIFR;BMPR2;FGFR4;ZIC3;WNT1;NODAL;ID3 |
Melanogenesis | GNAI3;FZD7A;PLCB2;DVL3A;WNT9A;WNT7B;CALM2;CALM2A;WNT7AA |
HTLV-I infection | HLA-DRB5;WNT4;MYBL1;NFYB;NFKB2;WNT2;RELB;MYBL2;SLC2A1 |
Pathways in cancer | BRCA2;FZD6;FGF19;PDGFA;PAX8;TRAF3;FGF12;TRAF6;RXRG |
Proteoglycans in cancer | PRKACB;TNF;WNT8B;WNT9A;SDC4;SDC1;MAP2K1;SMO;VEGFA |
Basal cell carcinoma | FZD7;SMO;GLI3;FZD6;AXIN1;TCF7;WNT2B;WNT16;WNT10B |
Wnt5a has several biochemical functions, for example, cytokine activity, frizzled binding, frizzled-2 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Wnt5a itself. We selected most functions Wnt5a had, and list some proteins which have the same functions with Wnt5a. You can find most of the proteins on our site.
Function | Related Protein |
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cytokine activity | MSTNA;IL8L2;IL12BA;IL22;IL1B;BMP1;LEFTY2;IL17A;IFNG |
frizzled binding | WNT2B;FZD1;WNT9A;WNT11;WNT4;DVL1B;SFRP1;DVL3;WNT2BB |
frizzled-2 binding | WNT5A;WNT3A |
protein domain specific binding | ITGA3;CALM;LIN7B;ARRB2;CASKIN1;RUNX2;SHC4;PTPN11;CHMP2B |
receptor agonist activity | NODAL;WNT3;WNT4;SFRP2;CXCL13;WNT3A;WNT8A;WNT1;GREM1 |
receptor tyrosine kinase-like orphan receptor binding | |
transcription factor activity, sequence-specific DNA binding | POU4F3;ATOH1;MLLT10;MSRB2;SP3A;FOXD5;NR1D4A;VDRA;DLX4 |
transcription regulatory region DNA binding | BCL11B;TP73;PAX8;ARID4A;GRHL2B;ZNF649;OVOL2;SP1;SREBF1 |
Wnt5a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Wnt5a here. Most of them are supplied by our site. Hope this information will be useful for your research of Wnt5a.
FZD5
- Q&As
- Reviews
Q&As (7)
Ask a questionIts role in cancer is complex, acting as a tumor suppressor or promoter depending on context.
It binds to Frizzled receptors and co-receptors, activating non-canonical Wnt signaling pathways.
WNT5A is involved in embryonic development, particularly in limb formation and organogenesis.
WNT5A modulates various immune responses, influencing inflammation and cell migration.
WNT5A is crucial in regulating cell proliferation, migration, and differentiation.
Strategies include developing WNT5A modulators for potential use in cancer therapy and regenerative medicine.
Genetic mutations and altered expression of WNT5A are linked to developmental disorders and cancer.
Customer Reviews (3)
Write a reviewSatisfied with performance, quality.
Great product, satisfied customer.
High purity, works well.
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