Recombinant Human WNT5A, GST-tagged
Cat.No. : | WNT5A-2052H |
Product Overview : | Recombinant Human WNT5A (201 a.a. - 300 a.a.) fused with GST-tag at N-terminal, was expressed in vitro wheat germ expression system. |
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Cat. No. : | WNT5A-2052H |
Description : | The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. |
Source : | wheat germ |
Molecular Mass : | 36.74 kDa |
Sequence : | ERERIHAKGSYESARILMNLHNNEA GRRTVYNLADVACKCHGVSGSCSLK TCWLQLADFRKVGDALKEKYDSAAA MRLNSRGKLVQVNSRFNSPTTQDLV |
Purification : | Glutathione Sepharose 4 Fast Flow |
Storage buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer. |
Applications : | ELISA; WB |
Storage : | Store at -80°C. Aliquot to avoid repeated freezing and thawing. |
Note : | Best use within three months from the date of receipt of this protein. |
OfficialSymbol : | WNT5A |
Gene Name : | WNT5A wingless-type MMTV integration site family, member 5A [ Homo sapiens ] |
Synonyms : | WNT5A; wingless-type MMTV integration site family, member 5A; protein Wnt-5a; hWNT5A; WNT 5A protein; WNT-5A protein |
Gene ID : | 7474 |
mRNA Refseq : | NM_001256105 |
Protein Refseq : | NP_001243034 |
MIM : | 164975 |
UniProt ID : | P41221 |
Chromosome Location : | 3p21-p14 |
Pathway : | Basal cell carcinoma; Class B/2 (Secretin family receptors); DNA damage response (only ATM dependent); GPCR ligand binding; HTLV-I infection |
Function : | cytokine activity; frizzled binding; frizzled-2 binding; protein domain specific binding; receptor agonist activity; receptor tyrosine kinase-like orphan receptor binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding |
Products Types
◆ Recombinant Protein | ||
WNT5A-2951H | Recombinant Human WNT5A Full Length protein, His-tagged | +Inquiry |
Wnt5a-65R | Recombinant Rat Wnt5a Protein, His-tagged | +Inquiry |
WNT5A-5884H | Recombinant Human WNT5A protein, His-tagged | +Inquiry |
WNT5A-3765H | Recombinant Human WNT5A Full Length protein, His-tagged | +Inquiry |
WNT5A-20H | Recombinant Human?WNT5A?Full Length Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
WNT5A-293HCL | Recombinant Human WNT5A 293 Cell Lysate | +Inquiry |
Related Gene
Not For Human Consumption!
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Customer Reviews (3)
Write a reviewSatisfied with performance, quality.
Great product, satisfied customer.
High purity, works well.
Q&As (7)
Ask a questionIts role in cancer is complex, acting as a tumor suppressor or promoter depending on context.
It binds to Frizzled receptors and co-receptors, activating non-canonical Wnt signaling pathways.
WNT5A is involved in embryonic development, particularly in limb formation and organogenesis.
WNT5A modulates various immune responses, influencing inflammation and cell migration.
WNT5A is crucial in regulating cell proliferation, migration, and differentiation.
Strategies include developing WNT5A modulators for potential use in cancer therapy and regenerative medicine.
Genetic mutations and altered expression of WNT5A are linked to developmental disorders and cancer.
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