Recombinant Mouse Wnt5a protein, His/GST-tagged

Cat.No. : Wnt5a-2055M
Product Overview : Recombinant Mouse Wnt5a(Ile62~Lys380) fused with His/GST tag at N-terminal was expressed in E. coli.
Availability December 04, 2024
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Description : Wnt5a played an important role in many functions.
Source : E. coli
Species : Mouse
Tag : His&GST
Form : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Molecular Mass : 62.2kDa
Protein length : Ile62~Lys380
AA Sequence : MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GGPLGSEF- IIGAQPLCS QLAGLSQGQK KLCHLYQDHM QYIGEGAKTG IKECQYQFRH RRWNCSTVDN TSVFGRVMQI GSRETAFTYA VSAAGVVNAM SRACREGELS TCGCSRAARP KDLPRDWLWG GCGDNIDYGY RFAKEFVDAR ERERIHAKGS YESARILMNL HNNEAGRRTV YNLADVACKC HGVSGSCSLK TCWLQLADFR KVGDALKEKY DSAAAMRLNS RGKLVQVNSR FNSPTTQDLV YIDPSPDYCV RNESTGSLGT QGRLCNKTSE GMDGCELMCC GRGYDQFKTV QTERCHCKFH WCCYVKCKKC TEIVDQFVCK
Endotoxin : <1.0eu per 1µg (determined by the lal>
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : Wnt5a wingless-related MMTV integration site 5A [ Mus musculus ]
Official Symbol : Wnt5a
Synonyms : WNT5A; wingless-related MMTV integration site 5A; protein Wnt-5a; Wnt-5a; 8030457G12Rik;
Gene ID : 22418
mRNA Refseq : NM_001256224
Protein Refseq : NP_001243153
MIM :
UniProt ID : P22725
Chromosome Location : 14 A3; 14 16.8 cM
Pathway : Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; Class B/2 (Secretin family receptors), organism-specific biosystem; ESC Pluripotency Pathways, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem;
Function : cytokine activity; frizzled binding; frizzled binding; frizzled-2 binding; protein binding; protein domain specific binding; receptor binding; receptor binding; receptor tyrosine kinase-like orphan receptor binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding;

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
11/14/2019

    Satisfied with performance, quality.

    08/27/2019

      Great product, satisfied customer.

      02/27/2019

        High purity, works well.

        Q&As (7)

        Ask a question
        What role does WNT5A play in cancer biology? 09/05/2022

        Its role in cancer is complex, acting as a tumor suppressor or promoter depending on context.

        How does WNT5A interact with its receptors to initiate signal transduction? 04/24/2022

        It binds to Frizzled receptors and co-receptors, activating non-canonical Wnt signaling pathways.

        In which developmental processes is WNT5A critically involved? 03/14/2022

        WNT5A is involved in embryonic development, particularly in limb formation and organogenesis.

        How is WNT5A implicated in immune system regulation? 01/03/2022

        WNT5A modulates various immune responses, influencing inflammation and cell migration.

        What is the primary role of WNT5A in cellular processes? 10/29/2020

        WNT5A is crucial in regulating cell proliferation, migration, and differentiation.

        What therapeutic strategies are being explored involving WNT5A modulation? 11/14/2019

        Strategies include developing WNT5A modulators for potential use in cancer therapy and regenerative medicine.

        Are there known genetic mutations in WNT5A associated with specific diseases? 02/27/2019

        Genetic mutations and altered expression of WNT5A are linked to developmental disorders and cancer.

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