Recombinant Human WNT5A, GST-tagged

• Cat.No.: WNT5A-2055H
• Product Overview: Recombinant Human WNT5A (1 aa. - 380 aa.) fused with GST-tag at N-terminal, was expressed in wheat germ.

Specification

• Cat. No.: WNT5A-2055H
• Description: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
• Source: wheat germ
• Molecular Mass: 68.7 kDa
• Sequence: MKKSIGILSPGVALGMAGSAMSSKF FLVALAIFFSFAQVVIEANSWWSLG MNNPVQMSEVYIIGAQPLCSQLAGL SQGQKKLCHLYQDHMQYIGEGAKTG IKECQYQFRHRRWNCSTVDNTSVFG RVMQIGSRETAFTYAVSAAGVVNAM SRACREGELSTCGCSRAARPKDLPR DWLWGGCGDNIDYGYRFAKEFVDAR ERERIHAKGSYESARILMNLHNNEA GRRTVYNLADVACKCHGVSGSCSLK TCWLQLADFRKVGDALKEKYDSAAA MRLNSRGKLVQVNSRFNSPTTQDLV YIDPSPDYCVRNESTGSLGTQGRLC NKTSEGMDGCELMCCGRGYDQFKTV QTERCHCKFHWCCYVKCKKCTEIVD QFVCK
• Storagebuffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
• Applications: ELISA; WB
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• OfficialSymbol: WNT5A

Gene Information

• Gene Name: WNT5A wingless-type MMTV integration site family, member 5A [ Homo sapiens ]
• Synonyms: WNT5A; wingless-type MMTV integration site family, member 5A; protein Wnt-5a; hWNT5A; WNT 5A protein; WNT-5A protein
• Gene ID: 7474
• mRNA Refseq: NM_003392
• Protein Refseq: NP_003383
• MIM: 164975
• UniProt ID: P41221
• Chromosome Location: 3p21-p14
• Pathway: Basal cell carcinoma; Class B/2 (Secretin family receptors); DNA damage response (only ATM dependent); GPCR ligand binding; HTLV-I infection
• Function: cytokine activity; frizzled binding; frizzled-2 binding; protein domain specific binding; receptor agonist activity; receptor tyrosine kinase-like orphan receptor binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding

Reviews

11/14/2019

Satisfied with performance, quality.

08/27/2019

Great product, satisfied customer.

02/27/2019

High purity, works well.

Q&As

What role does WNT5A play in cancer biology?

Its role in cancer is complex, acting as a tumor suppressor or promoter depending on context.

How does WNT5A interact with its receptors to initiate signal transduction?

It binds to Frizzled receptors and co-receptors, activating non-canonical Wnt signaling pathways.

In which developmental processes is WNT5A critically involved?

WNT5A is involved in embryonic development, particularly in limb formation and organogenesis.

How is WNT5A implicated in immune system regulation?

WNT5A modulates various immune responses, influencing inflammation and cell migration.

What is the primary role of WNT5A in cellular processes?

WNT5A is crucial in regulating cell proliferation, migration, and differentiation.

What therapeutic strategies are being explored involving WNT5A modulation?

Strategies include developing WNT5A modulators for potential use in cancer therapy and regenerative medicine.

Are there known genetic mutations in WNT5A associated with specific diseases?

Genetic mutations and altered expression of WNT5A are linked to developmental disorders and cancer.