AGTR1
-
Official Full Name
angiotensin II receptor, type 1
-
Overview
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. -
Synonyms
AGTR1; angiotensin II receptor, type 1; AGTR1B, angiotensin receptor 1B; type-1 angiotensin II receptor; AG2S; AGTR1A; AT1; AT1B; AT2R1; AT2R1A; AT2R1B; HAT1R; Agtr 1; AGTR1_HUMAN; AGTR1B; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; Angiotensin II type-1 receptor; AT 1B; AT 1r; At1a; AT1AR; AT1BR; Type 1 angiotensin II receptor; angiotensin receptor 1; angiotensin receptor 1B; type-1B angiotensin II receptor; AT1R;
- Recombinant Proteins
- Cell & Tissue Lysates
- Assay Kits
- Bos taurus (Bovine)
- Canis lupus familiaris (Dog) (Canis familiaris)
- Cavia porcellus (Guinea pig)
- Chicken
- Gallus gallus (Chicken)
- Human
- Meleagris gallopavo (Wild turkey)
- Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
- Oryctolagus cuniculus (Rabbit)
- Ovis aries (Sheep)
- Pan troglodytes (Chimpanzee)
- Sus scrofa (Pig)
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- Flag
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- AGTR1 Related Research Area
- AGTR1 Related Signal Pathway
AGTR1 involved in several pathways and played different roles in them. We selected most pathways AGTR1 participated on our site, such as ACE Inhibitor Pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with AGTR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ACE Inhibitor Pathway | AGTR1;ACE;CTSG;CMA1;CYP11B2;AGTR2;ATP6AP2;AGT |
| Adrenergic signaling in cardiomyocytes | AGTR1B;PPP2R2A;PPP1R1A;VMHC;CREB3L3L;TPM1;ADRB2A;ACTC1;PPP2R5B |
| Aldosterone synthesis and secretion | PRKD3;MC2R;ATF6B;LIPE;AGTR1A;CREB5;CYP11A1;DDX1;Adcy4 |
| Angiopoietin receptor Tie2-mediated signaling | CDKN1A;ELF1;CRK;DOK2;ELF2;GRB14;BMX;AGTR1;GRB7 |
| Arf6 signaling events | ADRB2;ARAP2;IPCEF1;ADAP1;EFNA1;GULP1;EGF;USP6;EPHA2 |
| Calcium signaling pathway | ERBB3A;STIM1A;GRIN1A;CCKAR;TACR1;PLCD1;EDNRBA;CACNA1DA;PTGER3 |
| Class A/1 (Rhodopsin-like receptors) | CX3CR1;CHRM2;CCRL2;PYYA;OPN1MW2;CHRM1;CCR1;SSTR3;RLN3 |
| G alpha (q) signalling events | NMU;AGTR1;CCK;LPAR5A;RASGRP2;NTS;DGKB;MLN;FFAR3 |
AGTR1 has several biochemical functions, for example, angiotensin type I receptor activity, angiotensin type II receptor activity, bradykinin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGTR1 itself. We selected most functions AGTR1 had, and list some proteins which have the same functions with AGTR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| angiotensin type I receptor activity | AGTR1B;AGTR1;AGTR1A |
| angiotensin type II receptor activity | AGTR1;APLNRB;AGTRAP;AGTR1B;RXFP4;AGTR2;CXCR3.2;AGTR1A;APLNRA |
| bradykinin receptor binding | AGTR1;ACE;AGTR1A |
| protein binding | NTHL1;CT45A3;TAGLN2;OFCC1;HER11;POLD3;FRG1;SLC3A1;RBP4 |
| protein heterodimerization activity | POU5F3;HIST1H4L;RALGAPA2;GABPA;SRI;ADORA2A;MAP3K7;CD3D;AGTR1 |
AGTR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGTR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AGTR1.
AGT; AGT; ARRB1; GNAQ; PLCG1
- Q&As
- Reviews
Q&As (10)
Ask a questionAGTR1 activation in the kidneys leads to vasoconstriction of renal blood vessels, increased sodium reabsorption, and stimulation of aldosterone release, ultimately impacting renal function.
Overactivation of AGTR1 can lead to increased vasoconstriction, sodium retention, and stimulation of aldosterone release, all of which contribute to hypertension.
AGTR1 is widely expressed throughout the body, with high levels found in the cardiovascular system, kidneys, and adrenal glands.
Yes, genetic variations in the AGTR1 gene have been associated with increased susceptibility to cardiovascular diseases, hypertension, and other conditions influenced by the renin-angiotensin system.
AGTR1 activation can modulate inflammatory responses, contributing to inflammation-associated conditions such as atherosclerosis and chronic kidney disease.
Upon angiotensin II binding, AGTR1 activates intracellular signaling pathways, such as G-protein-mediated pathways and the activation of downstream kinases.
AGTR1 activation can promote angiogenesis, the formation of new blood vessels, by stimulating endothelial cell proliferation and migration.
AGTR1 can activate pathways such as the phosphoinositide 3-kinase (PI3K)/Akt pathway, mitogen-activated protein kinase (MAPK) pathway, and the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway.
AGTR1 has been implicated in cancer development and progression due to its role in cellular growth, angiogenesis, and inflammation.
AGTR1 activation can promote the generation of reactive oxygen species, contributing to oxidative stress and cellular damage.
Customer Reviews (5)
Write a reviewIt's like a ray of sunshine in our experiments, bringing joy and reliable data. A true delight to work with!
I have been a loyal customer of this supplier for years due to their commitment to delivering proteins of exceptional quality at competitive prices.
The post-sale services provided detailed technical support and ensured that I had a positive experience with their products.
Love the affordable price and great quality of the recombinant proteins I purchased!
Ask a Question for All AGTR1 Products
Required fields are marked with *
My Review for All AGTR1 Products
Required fields are marked with *
