Active Recombinant Human APOE Protein, Myc/DDK-tagged

• Cat.No.: APOE-088H
• Product Overview: Recombinant protein of human apolipoprotein E (APOE) with a C-Myc/DDK tag was expressed in HEK293T.

Specification

• Description: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
• Source: HEK293T
• Species: Human
• Tag: Myc/DDK
• Bio-activity: Binding assay
• Molecular Mass: 34.2 kDa
• AA Sequence: MKVLWAALLVTFLAGCQAKVEQAVE TEPEPELRQQTEWQSGQRWELALGR FWDYLRWVQTLSEQVQEELLSSQVT QELRALMDETMKELKAYKSELEEQL TPVAEETRARLSKELQAAQARLGAD MEDVCGRLVQYRGEVQAMLGQSTEE LRVRLASHLRKLRKRLLRDADDLQK RLAVYQAGAREGAERGLSAIRERLG PLVEQGRVRAATVGSLAGQPLQERA QAWGERLRARMEEMGSRTRDRLDEV KEQVAEVRAKLEEQAQQIRLQAEAF QARLKSWFEPLVEDMQRQWAGLVEK VQAAVGTSAAPVPSDNH
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: APOE apolipoprotein E [ Homo sapiens (human) ]
• Official Symbol: APOE apolipoprotein E [ Homo sapiens (human) ]
• Synonyms: APOE; apolipoprotein E; AD2; LPG; APO-E; ApoE4; LDLCQ5; apolipoprotein E; apolipoprotein E3
• Gene ID: 348
• mRNA Refseq: NM_000041
• Protein Refseq: NP_000032
• MIM: 107741
• UniProt ID: P02649