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Recombinant Rat Casp4 Protein, His-tagged

Cat.No. : Casp4-626R
Product Overview : Recombinant Rat Casp4 Protein (Met1-Asn373) with His tag was expressed in E. coli.
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  • Gene Information
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Description : Enables scaffold protein binding activity. Predicted to be involved in several processes, including cellular response to amyloid-beta; positive regulation of tumor necrosis factor-mediated signaling pathway; and protein autoprocessing. Predicted to act upstream of or within ectopic germ cell programmed cell death; positive regulation of interleukin-1 beta production; and pyroptosis. Located in neuron projection and neuronal cell body. Part of protein-containing complex. Orthologous to human CASP4 (caspase 4).
Source : E. coli
Species : Rat
Tag : N-His
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 46.4 kDa; Accurate Molecular Mass: 46 kDa
Protein length : Met1-Asn373
Purity : > 90%
Applications : Positive Control; Immunogen; SDS-PAGE; WB.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Storage Buffer : PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Reconstitution : Reconstitute in PBS or others.
Gene Name : Casp4 caspase 4, apoptosis-related cysteine peptidase [ Rattus norvegicus (Norway rat) ]
Official Symbol : Casp4
Synonyms : CASP4; caspase 4, apoptosis-related cysteine peptidase; caspase 4; caspase 11; Casp11; MGC124949;
Gene ID : 114555
mRNA Refseq : NM_053736
Protein Refseq : NP_446188
UniProt ID : E9PSM0

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How is CASP4 protein linked to sepsis? 07/01/2020

CASP4 protein is involved in the recognition of bacterial lipopolysaccharide (LPS) and the initiation of the inflammatory response, which can contribute to the development of sepsis.

How does CASP4 protein interact with other proteins in the inflammatory pathway? 12/19/2019

CASP4 protein interacts with other caspases and inflammatory mediators, contributing to the amplification of the inflammatory response.

How is CASP4 protein involved in inflammation? 07/30/2018

CASP4 protein plays a role in the activation of inflammatory pathways and the production of inflammatory cytokines in response to bacterial infection.

Are there any drugs targeting CASP4 protein in clinical development? 11/10/2017

Several pharmaceutical companies are researching potential inhibitors of CASP4 protein as a strategy for treating inflammatory conditions.

How can CASP4 protein be used as a diagnostic biomarker? 09/18/2017

Elevated levels of CASP4 protein in the blood may indicate the presence of inflammation or infection, and could be used as a diagnostic marker for such conditions.

Customer Reviews (3)

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09/03/2017

    By relying on the CASP4 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.

    08/05/2016

      Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.

      06/28/2016

        In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the CASP4 protein.

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