Recombinant Human CASP4 Protein, His-tagged

• Cat.No.: CASP4-820H
• Product Overview: Recombinant Human CASP4, transcript variant alpha, fused with His tag at N-terminal was expressed in E. coli.

Specification

• Description: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol, 1 % Sarkosyl. Store at -80 centigrade. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
• Molecular Mass: 43.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: CASP4 caspase 4, apoptosis-related cysteine peptidase [ Homo sapiens ]
• Official Symbol: CASP4
• Synonyms: CASP4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis related cysteine protease; caspase-4; ICE(rel)II; ICH 2; TX; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease; ICH-2; Mih1/TX; ICEREL-II
• Gene ID: 837
• mRNA Refseq: NM_001225
• Protein Refseq: NP_001216
• MIM: 602664
• UniProt ID: P49662