Recombinant Human CASP4

• Cat.No.: CASP4-26607TH
• Product Overview: Recombinant full length protein (Human)

Specification

• Description: This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
• Source: E. coli
• Tissue specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.
• Biological activity: 5000 units/mg.
• Form: Lyophilised:Reconstitute to 1 unit per μl in PBS containing 15% glycerol. Aliquot and store immediately at -80°C.
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 15% Glycerol, PBS
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the peptidase C14A family.Contains 1 CARD domain.

Gene Information

• Gene Name: CASP4 caspase 4, apoptosis-related cysteine peptidase [ Homo sapiens ]
• Official Symbol: CASP4
• Synonyms: CASP4; caspase 4, apoptosis-related cysteine peptidase; caspase 4, apoptosis related cysteine protease; caspase-4; ICE(rel)II; ICH 2; TX
• Gene ID: 837
• mRNA Refseq: NM_001225
• Protein Refseq: NP_001216
• MIM: 602664
• Uniprot ID: P49662
• Chromosome Location: 11q22.2-q22.3
• Pathway: Apoptosis, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NOD1/2 Signaling Pathway, organism-specific biosystem
• Function: cysteine-type endopeptidase activity; peptidase activity

Reviews

09/03/2017

By relying on the CASP4 protein and the manufacturer's exceptional technical support, researchers can confidently pursue their experimental goals while knowing they have access to reliable resources and expert guidance.

08/05/2016

Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various disciplines.

06/28/2016

In addition to their expertise, the manufacturer's technical support team can assist in troubleshooting and optimizing the handling and application of the CASP4 protein.

Q&As

How is CASP4 protein linked to sepsis?

CASP4 protein is involved in the recognition of bacterial lipopolysaccharide (LPS) and the initiation of the inflammatory response, which can contribute to the development of sepsis.

How does CASP4 protein interact with other proteins in the inflammatory pathway?

CASP4 protein interacts with other caspases and inflammatory mediators, contributing to the amplification of the inflammatory response.

How is CASP4 protein involved in inflammation?

CASP4 protein plays a role in the activation of inflammatory pathways and the production of inflammatory cytokines in response to bacterial infection.

Are there any drugs targeting CASP4 protein in clinical development?

Several pharmaceutical companies are researching potential inhibitors of CASP4 protein as a strategy for treating inflammatory conditions.

How can CASP4 protein be used as a diagnostic biomarker?

Elevated levels of CASP4 protein in the blood may indicate the presence of inflammation or infection, and could be used as a diagnostic marker for such conditions.