CBS
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Official Full Name
cystathionine-beta-synthase
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Overview
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene. -
Synonyms
CBS; cystathionine-beta-synthase; cystathionine beta-synthase; HIP4; beta-thionase; serine sulfhydrase; methylcysteine synthase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cynomolgus Monkey
- Human
- Mouse
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- E.coli
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- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- SUMO
- Myc
- DDK
- MYC
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CBS Related Articles
CBS involved in several pathways and played different roles in them. We selected most pathways CBS participated on our site, such as Glycine, serine and threonine metabolism, Cysteine and methionine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycine, serine and threonine metabolism | MAOB;AGXT2;AGXTB;DLDH;PIPOX;THA1;AMT;ALAS2;GATM |
| Cysteine and methionine metabolism | AHCYL1;LDHAL6A;DNMT3;LDHAL6B;LDHBB;MTR;LDHBA;AGXT2;SDS |
| Metabolic pathways | AGPAT9L;MTHFS;PSPH;NDUFS5;CYP2B6;PPAP2C;DNMT4;ALDH18A1;PDXK |
| Biosynthesis of amino acids | GPT2;PGK1;GLULA;BCAT1;ENO3;SDSL;PKM;PFKL;BCAT2 |
CBS has several biochemical functions, for example, S-adenosyl-L-methionine binding, carbon monoxide binding, cystathionine beta-synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CBS itself. We selected most functions CBS had, and list some proteins which have the same functions with CBS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| S-adenosyl-L-methionine binding | |
| carbon monoxide binding | |
| cystathionine beta-synthase activity | CBSB;CBS;CBSA |
| enzyme binding | HDHD2;RXRA;ATF7;PHKG2;NPC2;NKX2-1;AXIN2;LAMP2;GSTM2 |
| heme binding | CYP7A1A;CYP3C1L2;CYP17A1;ABCB6;CYP2D6;CYP1C2;CYP7B1;CYP20A1;HBAA |
| identical protein binding | LDHB;HCFC1;INS;PACSIN2;CLDN7;CLDND;PHC2;PAK2;DYNLT1A |
| metal ion binding | ZNF76;TRIM109;U2AF1L4;ASXL1;ACACA;RNASEL;ZDHHC23B;ZNF75A;CHPF |
| modified amino acid binding | DPEP1;MTHFR;CBS;MUT;CPS1;NOX4 |
| nitric oxide binding | CBS;GSTP1 |
| nitrite reductase (NO-forming) activity | |
| oxygen binding | CYP2D9;HBZ;BA1;CYP2B6;CYP26A1;HBD;CYP2AD3;CYP2K6;FAM84B |
| protein binding | LY6H;EPHB4;ZMYND11;ZNF124;BEGAIN;SERPINF2;CYP2S1;RBM3;HEMGN |
| protein homodimerization activity | GDNF;TRPM8;ATG7;ENO2;MBL1;BLOC1S6;PEX7;KCNK3;CISD2 |
| pyridoxal phosphate binding | AGXT2;PYGB;CTHL;PHYKPL;DDC;GPT2L;GAD1;SGPL1;PDXDC1 |
| ubiquitin protein ligase binding | MUL1;UBE2A;DLG3;AXIN1;MFN2;MOAP1;RB1;YOD1;CUL4B |
CBS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBS here. Most of them are supplied by our site. Hope this information will be useful for your research of CBS.
PSMA1; PRKAG1; UBASH3A; EHHADH; PIN1; UBE2I
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