Recombinant Mouse CBS Protein (2-561 aa), His-tagged

• Cat.No.: CBS-1960M
• Product Overview: Recombinant Mouse CBS Protein (2-561 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Cancer. Protein Description: Full Length of Mature Protein.

Specification

• Description: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (By similarity). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.
• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 63.4 kDa
• Protein length: 2-561 aa
• AA Sequence: PSGTSQCEDGSAGGFQHLDMHSEKR QLEKGPSGDKDRVWIRPDTPSRCTW QLGRAMADSPHYHTVLTKSPKILPD ILRKIGNTPMVRINKISKNAGLKCE LLAKCEFFNAGGSVKDRISLRMIED AERAGNLKPGDTIIEPTSGNTGIGL ALAAAVKGYRCIIVMPEKMSMEKVD VLRALGAEIVRTPTNARFDSPESHV GVAWRLKNEIPNSHILDQYRNASNP LAHYDDTAEEILQQCDGKLDMLVAS AGTGGTITGIARKLKEKCPGCKIIG VDPEGSILAEPEELNQTEQTAYEVE GIGYDFIPTVLDRAVVDKWFKSNDE DSFAFARMLIAQEGLLCGGSSGSAM AVAVKAARELQEGQRCVVILPDSVR NYMSKFLSDKWMLQKGFMKEELSVK RPWWWRLRVQELSLSAPLTVLPTVT CEDTIAILREKGFDQAPVVNESGAI LGMVTLGNMLSSLLAGKVRPSDEVC KVLYKQFKPIHLTDTLGTLSHILEM DHFALVVHEQIQSRDQAWSGVVGGP TDCSNGMSSKQQMVFGVVTAIDLLN FVAAREQTQT
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Cbs cystathionine beta-synthase [ Mus musculus ]
• Official Symbol: CBS
• Synonyms: CBS; beta-thionase; HIP4; AI047524; AI303044; MGC18856; MGC18895; MGC37300
• Gene ID: 12411
• mRNA Refseq: NM_144855
• Protein Refseq: NP_659104
• UniProt ID: Q91WT9