CCL20
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Official Full Name
chemokine (C-C motif) ligand 20
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Background
Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6. -
Synonyms
CCL20; chemokine (C-C motif) ligand 20; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; C-C motif chemokine 20; exodus-1; MIP-3-alpha; CC chemokine LARC; OTTHUMP00000164245; OTTHUMP00000204113; beta chemokine exodus-1; beta-chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20; MIP-3[a]; OTTMUSP00000017965; OTTMUSP00000017966;
- Involved Pathway
- Protein Function
- Interacting Protein
- CCL20 Related Articles
- CCL20 Related Gene Family
- CCL20 Related Research Area
CCL20 involved in several pathways and played different roles in them. We selected most pathways CCL20 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF13C;VEGFAB;TNFRSF10B;IFNW1;CCL27B;TGFB1;TNFSF14;IL2RG;LEPB |
| Chemokine signaling pathway | HCK;CCR10;CCL6;PLCB1;VAV2;MAPK3;LYN;GRK7;PAK1 |
| TNF signaling pathway | RPS6KA5;PGAM5;NFKB1;AKT2;ATF4;BCL3;MAP3K5;IKBKB;VEGFC |
| Rheumatoid arthritis | IL17A;ATP6V0D2;TNFRSF11A;CCL2;GM-CSF;TGFB3;VEGFA;CCL3;ATP6V0E1 |
CCL20 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL20 itself. We selected most functions CCL20 had, and list some proteins which have the same functions with CCL20. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CCR chemokine receptor binding | CCL34B.1;CCL20B;CCL44;CCL19;CCL34B.4;CCL22;CX3CL1;CCL15;CCL38A.5 |
| chemokine activity | CCL2;AMCF-II;CCL38A.4;CCL21B;IL-8;CXCL2;CCL3;CCL5;CCL14 |
| protein binding | C16orf87;TRAPPC10;KRT1;KLRG1;PLD1;RTN4;NFIL3;DDB2;ACMSD |
CCL20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL20 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL20.
RALBP1; TRAF6; TGFB3
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