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CCL20

  • Official Full Name

    chemokine (C-C motif) ligand 20

  • Overview

    Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family. It is strongly chemotactic for lymphocytes and weakly attracts neutrophils. CCL20 is implicated in the formation and function of mucosal lymphoid tissues via chemoattraction of lymphocytes and dendritic cells towards the epithelial cells surrounding these tissues. CCL20 elicits its effects on its target cells by binding and activating the chemokine receptor CCR6.
  • Synonyms

    CCL20; chemokine (C-C motif) ligand 20; CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; C-C motif chemokine 20; exodus-1; MIP-3-alpha; CC chemokine LARC; OTTHUMP00000164245; OTTHUMP00000204113; beta chemokine exodus-1; beta-chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20; MIP-3[a]; OTTMUSP00000017965; OTTMUSP00000017966;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Macaca mulatta
  • Mouse
  • Rabbit
  • Rat
  • Rhesus macaque
  • Rhesus Macaque
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Biotin
  • Fc
  • GST
  • HIgG1 Fc
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • MIgG2a Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL20-296H Active Recombinant Human CCL20 E.coli N/A
Human CCL20-11H Recombinant Human CCL20 protein E.coli N/A 70
Human CCL20-166H Recombinant Human CCL20, His-tagged E.coli His
Human CCL20-517H Active Recombinant Human CCL20 Protein, HIgG1 Fc-tagged CHO HIgG1 Fc
Human CCL20-161H Recombinant Human CCL20, His tagged E.coli His Ala27-Met96
Human CCL20-515H Active Recombinant Human CCL20 Protein, HIgG1 Fc-tagged, mutant CHO HIgG1 Fc
Human CCL20-0624H Recombinant Human CCL20 Protein, GST-Tagged Wheat Germ GST
Human CCL20-516H Active Recombinant Human CCL20 Protein, MIgG2a Fc-tagged CHO MIgG2a Fc
Human CCL20-717H Recombinant Human CCL20 protein, His & GST-tagged E.coli His/GST Ala27~Met96 (Accession # P78556)
Human CCL20-22H Active Recombinant Human CCL20 Protein CHO N/A
Human CCL20-61H Recombinant Human CCL20 Protein, Biotin-tagged E.coli Biotin
Human CCL20-151H Recombinant Human CCL20 Protein, His-tagged Human Cells His
Human CCL20-2651H Recombinant Human CCL20 protein, GST-tagged E.coli GST 27-95aa
Human CCL20-518H Recombinant Human CCL20 Protein, Fc-tagged HEK293 Fc
Human CCL20-327C Active Recombinant Human CCL20 Protein (70 aa) E.coli 70
Human CCL20-47H Recombinant Human CCL20 Protein E.coli 70 amino acid
Human CCL20-641H Recombinant Human CCL20 Protein, GST-tagged E.coli N-GST Ala27-Met96
Human CCL20-218C Active Recombinant Human CCL20 Protein (70 aa) CHO 70
Human CCL20-2951HF Recombinant Full Length Human CCL20 Protein, GST-tagged In Vitro Cell Free System GST 95 amino acids
Human CCL20-0752H Recombinant Human CCL20 Protein (Ser28-Met96), N-His tagged E.coli N-His Ser28-Met96
Human CCL20-17H Active Recombinant Human CCL20 Protein E.coli
Human CCL20-2729H Recombinant Human CCL20 Protein (Ser27-Met96), His tagged E.coli His Ser27-Met96
Human CCL20-073C Active Recombinant Human CCL20 Protein (70 aa) E.coli 70
Mouse CCL20-50M Recombinant Mouse CCL20 protein E.coli N/A 70
Mouse Ccl20-833M Recombinant Mouse Ccl20 Protein, His-tagged Insect Cell His
Mouse CCL20-447MCL Recombinant Mouse CCL20 cell lysate Insect Cell N/A
Mouse Ccl20-2032M Active Recombinant Mouse Ccl20 Protein E. coli
Mouse CCL20-793M Recombinant Mouse CCL20 Protein (Ala28-Met97) E.coli N/A Ala28-Met97
Mouse CCL20-3403M Recombinant Mouse CCL20 protein(Ala28-Met97) E. coli N/A Ala28-Met97
Mouse CCL20-18M Active Recombinant Mouse CCL20 Protein E.coli
Rat Ccl20-409R Active Recombinant Rat Chemokine (C-C motif) Ligand 20 E.coli N/A
Rat Ccl20-719R Recombinant Rat Ccl20 protein, His & GST-tagged E.coli His/GST Glu24~Lys95 (Accession # P97884)
Rat CCL20-1212R Recombinant Rat CCL20 Protein Mammalian Cell His
Rat Ccl20-170C Active Recombinant Rat Ccl20 Protein (71 aa) HEK293 71
Rat Ccl20-2888R Recombinant Rat Ccl20 Protein E.coli N/A
Rat CCL20-870R-B Recombinant Rat CCL20 Protein Pre-coupled Magnetic Beads HEK293
Rat CCL20-870R Recombinant Rat CCL20 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit CCL20-4364R Recombinant Rabbit CCL20 Protein Yeast N/A 70aa
Bovine CCL20-5807B Recombinant Bovine CCL20 protein, His-tagged Yeast His 27-96aa
Bovine CCL20-1082B Recombinant Bovine CCL20 Protein (27-96 aa), His-SUMO-tagged E.coli His/SUMO 27-96 aa
Macaca mulatta CCL20-15M Recombinant Macaca mulatta CCL20 protein, GST-tagged E.coli GST
Rhesus Macaque CCL20-684R Recombinant Rhesus monkey CCL20 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCL20-512R-B Recombinant Rhesus Macaque CCL20 Protein Pre-coupled Magnetic Beads HEK293
Rhesus macaque CCL20-2652R Recombinant Rhesus macaque CCL20 protein, His-GST-tagged E.coli His/GST 27-96aa
Rhesus Macaque CCL20-512R Recombinant Rhesus Macaque CCL20 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CCL20-136C Recombinant Chicken Chemokine (C-C motif) Ligand 20 Yeast N/A
Chicken CCL20-6008C Recombinant Chicken CCL20 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CCL20 Related Articles
  • CCL20 Related Gene Family
  • CCL20 Related Research Area

CCL20 involved in several pathways and played different roles in them. We selected most pathways CCL20 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL20 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL1R1;TP-1;CCL21;CCL27;CCR1;TNFSF10;CCR9A;IL6;LTB
Chemokine signaling pathwayAKT2;PARD3;CCL27;RHOA;GRK7;CXCL6;CCL25;ROCK1;VAV2
TNF signaling pathwayMAPK12;PIK3R5;PIK3CA;IL18R1;PIK3CD;MMP14;BIRC2;Ccl12;MLKL
Rheumatoid arthritisCCL2;HLA-DRA;IFNG;CCL3L3;ATP6V1C1;ATP6AP1;ATP6V0C;CD86;ATP6V1C2

CCL20 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL20 itself. We selected most functions CCL20 had, and list some proteins which have the same functions with CCL20. You can find most of the proteins on our site.

Function Related Protein
CCR chemokine receptor bindingCCL34B.1;CX3CL1;CCL19B;CCL13;CCL18;CCL34A.4;CCL11;CCL8;CCL35.1
chemokine activityCCL39.1;CCL21;CCL3;CXCL12;CXCL6;CXCL13;CCL3L1;CCL34A.3;PPBP
protein bindingSETDB2;TRAF7;GNGT1;CRYGC;PRPF4B;MOBKL2B;TBX5;STMN2;CD14

CCL20 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL20 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL20.

RALBP1; TRAF6; TGFB3

Qin, T; Yin, YY; et al. Whole inactivated avian Influenza H9N2 viruses induce nasal submucosal dendritic cells to sample luminal viruses via transepithelial dendrites and trigger subsequent DC maturation. VACCINE 33:1382-1392(2015).
Wu, HH; Hwang-Verslues, WW; et al. Targeting IL-17B-IL-17RB signaling with an anti-IL-17RB antibody blocks pancreatic cancer metastasis by silencing multiple chemokines. JOURNAL OF EXPERIMENTAL MEDICINE 212:333-349(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What are the mechanisms by which CCL20 modulates the migration and differentiation of dendritic cells? 08/25/2022

CCL20 influences dendritic cell migration and differentiation, crucial for initiating immune responses.

How does CCL20 contribute to tumor progression and the formation of the tumor microenvironment in cancer? 07/07/2022

CCL20 contributes to cancer progression by shaping the tumor microenvironment and aiding tumor cell invasion.

What role does CCL20 play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 05/17/2022

CCL20 plays a significant role in autoimmune diseases by attracting inflammatory cells to affected joints.

How does CCL20 influence wound healing and tissue repair processes? 12/21/2021

CCL20 is involved in wound healing and tissue repair, facilitating immune cell migration and tissue regeneration.

How do alterations in CCL20 expression or signaling affect skin homeostasis and the development of skin diseases? 09/05/2021

Changes in CCL20 expression impact skin health, potentially contributing to the development of skin disorders.

How does CCL20 mediate the recruitment and activation of immune cells, particularly in inflammatory conditions? 08/22/2020

CCL20 recruits and activates immune cells to sites of inflammation, coordinating the immune response.

What is the impact of CCL20 on mucosal immunity, especially in the gut and respiratory tract? 08/06/2019

CCL20 impacts mucosal immunity, playing a critical role in immune defense in the gut and respiratory system.

Customer Reviews (3)

Write a review
Reviews
08/25/2020

    Expert protein engineering support, essential for our projects' progress.

    05/14/2020

      Consistent western blot results, an indispensable tool in our lab.

      08/22/2019

        Dependable protein quantification, ensures data precision in our work.

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