Recombinant Bovine CCL20 Protein (27-96 aa), His-SUMO-tagged

• Cat.No.: CCL20-1082B
• Product Overview: Recombinant Bovine CCL20 Protein (27-96 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Full Length of Mature Protein.

Specification

• Description: Chotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.
• Source: E. coli
• Species: Bovine
• Tag: His&SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 24.1 kDa
• Protein length: 27-96 aa
• AA Sequence: ASNFDCCLRYTERILHPSILVGFTQ QLANEACDINAVVFYTRKKLAVCAD PKKKWVKQVVHMLSQRVKRM
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: CCL20 C-C motif chemokine ligand 20 [ Bos taurus (cattle) ]
• Official Symbol: CCL20
• Gene ID: 281666
• mRNA Refseq: NM_174263
• Protein Refseq: NP_776688
• UniProt ID: Q8SQB1

Reviews

08/25/2020

Expert protein engineering support, essential for our projects' progress.

05/14/2020

Consistent western blot results, an indispensable tool in our lab.

08/22/2019

Dependable protein quantification, ensures data precision in our work.

Q&As

What are the mechanisms by which CCL20 modulates the migration and differentiation of dendritic cells?

CCL20 influences dendritic cell migration and differentiation, crucial for initiating immune responses.

How does CCL20 contribute to tumor progression and the formation of the tumor microenvironment in cancer?

CCL20 contributes to cancer progression by shaping the tumor microenvironment and aiding tumor cell invasion.

What role does CCL20 play in the pathogenesis of autoimmune diseases like rheumatoid arthritis?

CCL20 plays a significant role in autoimmune diseases by attracting inflammatory cells to affected joints.

How does CCL20 influence wound healing and tissue repair processes?

CCL20 is involved in wound healing and tissue repair, facilitating immune cell migration and tissue regeneration.

How do alterations in CCL20 expression or signaling affect skin homeostasis and the development of skin diseases?

Changes in CCL20 expression impact skin health, potentially contributing to the development of skin disorders.

How does CCL20 mediate the recruitment and activation of immune cells, particularly in inflammatory conditions?

CCL20 recruits and activates immune cells to sites of inflammation, coordinating the immune response.

What is the impact of CCL20 on mucosal immunity, especially in the gut and respiratory tract?

CCL20 impacts mucosal immunity, playing a critical role in immune defense in the gut and respiratory system.