Active Recombinant Rat Chemokine (C-C motif) Ligand 20

Cat.No. : Ccl20-409R
Product Overview : Recombinantrat Ccl20 protein was expressed in E. coli. Ala26-Met96.
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Cat. No. : Ccl20-409R
Description : Ccl20, also known asMIP3α, LARC (Liver and Activationregulated Chemokine) and as Exodus, is oneof many novel β chemokines identified through bioinformatics. Rat Ccl20 cDNAencodes a 96 amino acid (aa) precursor protein with a 25 aa putative signalpeptide that is predicted to be cleaved to form the 71 aa mature secretedprotein.
Source : E. coli
Form : Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrierprotein.
N-terminal Sequence : Ala26
Molecular Weight : 8.2 kDa
Activity : Measured by itsability to chemoattract human CCR6 transfected BaF3 mouse pro-B cells. The ED50for this effect is typically 0.5-3 μg/mL.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
Purity : >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstitute at 200μg/mL in sterile PBS that containing at least 0.1% human or bovine serumalbumin.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month,2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions afterreconstitution.
SDS-PAGE:
Gene Name : Ccl20 chemokine (C-C motif)ligand 20 [ Rattus norvegicus ]
Official Symbol : Ccl20
Synonyms : Ccl20; chemokine(C-C motif) ligand 20; ST38; Scya20; MIP-3-alpha; CCchemokine LARC; CC chemokine ST38; beta chemokine exodus-1; small-induciblecytokine A20; macrophage inflammatory protein 3 alpha; liver andactivation-regulated chemokine; beta-chemokine exodus-1; small induciblecytokine subfamily A20; C-C motif chemokine 20
Gene ID : 29538
mRNA Refseq : NM_019233
Protein Refseq : NP_062106
UniProt ID : P97884
Chromosome Location : 9q34
Pathway : Chemokine receptors bind chemokines; Chemokinesignaling pathway; Class A/1 (Rhodopsin-like receptors); Cytokine-cytokinereceptor interaction; G alpha (i) signalling events; GPCR downstreamsignaling; GPCR ligand binding; Peptide ligand-binding receptors; Rheumatoidarthritis; Signal Transduction; Signaling by GPCR
Function : chemokine activity; cytokine activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What are the mechanisms by which CCL20 modulates the migration and differentiation of dendritic cells? 08/25/2022

CCL20 influences dendritic cell migration and differentiation, crucial for initiating immune responses.

How does CCL20 contribute to tumor progression and the formation of the tumor microenvironment in cancer? 07/07/2022

CCL20 contributes to cancer progression by shaping the tumor microenvironment and aiding tumor cell invasion.

What role does CCL20 play in the pathogenesis of autoimmune diseases like rheumatoid arthritis? 05/17/2022

CCL20 plays a significant role in autoimmune diseases by attracting inflammatory cells to affected joints.

How does CCL20 influence wound healing and tissue repair processes? 12/21/2021

CCL20 is involved in wound healing and tissue repair, facilitating immune cell migration and tissue regeneration.

How do alterations in CCL20 expression or signaling affect skin homeostasis and the development of skin diseases? 09/05/2021

Changes in CCL20 expression impact skin health, potentially contributing to the development of skin disorders.

How does CCL20 mediate the recruitment and activation of immune cells, particularly in inflammatory conditions? 08/22/2020

CCL20 recruits and activates immune cells to sites of inflammation, coordinating the immune response.

What is the impact of CCL20 on mucosal immunity, especially in the gut and respiratory tract? 08/06/2019

CCL20 impacts mucosal immunity, playing a critical role in immune defense in the gut and respiratory system.

Customer Reviews (3)

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Reviews
08/25/2020

    Expert protein engineering support, essential for our projects' progress.

    05/14/2020

      Consistent western blot results, an indispensable tool in our lab.

      08/22/2019

        Dependable protein quantification, ensures data precision in our work.

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