CCL8
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Official Full Name
chemokine (C-C motif) ligand 8 -
Overview
Monocyte chemotactic protein-2 (MCP-2); is a non-glycosylated polypeptide that is a member of the C-C chemokine subfamily and it specifically attracts monocytes, lymphocytes, basophils and eosinophils. It also plays a role in neoplasia and inflammatory ho -
Synonyms
CCL8;chemokine (C-C motif) ligand 8;SCYA8, small inducible cytokine subfamily A (Cys Cys), member 8 (monocyte chemotactic protein 2);C-C motif chemokine 8;HC14;MCP 2;small-inducible cytokine A8;monocyte chemotactic protein 2;monocyte chemoattract
Recombinant Proteins
- Mouse
- Human
- Cattle
- Rhesus macaque
- Pig
- Horse
- Dog
- Canine
- E.coli
- CHO
- HEK293
- Mammalian Cells
- Human Cells
- Yeast
- GST
- SUMO
- His
- NusA
- Non
- Fc
- Flag
- T7
- Avi
Involved Pathway
CCL8 involved in several pathways and played different roles in them. We selected most pathways CCL8 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | CCL28,PIK3R5,GNG4,CCL2,WAS,HCK,CCR5,CDC42,GM1987,RAP1B |
| Cytokine-cytokine receptor interaction | IL20,LEPR,TNFSF13,BMP7,Il2,AMHR2,VEGFAB,TNFSF18,TNFSF13B,TNFRSF18 |
Protein Function
CCL8 has several biochemical functions, for example, CCR chemokine receptor binding,chemokine activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL8 itself. We selected most functions CCL8 had, and list some proteins which have the same functions with CCL8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase activity | CDK12,MMD2,ROCK2B,PRKDC,MAPKAPK2B,TBK1,DCLK1,PRKCHA,ERBB3A,IGF1RB |
| heparin binding | RSPO3,LPA,OGN,ADAMTS3,SAA1,RSPO1,VTN,LIPH,CXCL6,NRP1 |
| chemokine activity | CXCL12,CCL39.1,CCL20,CXL34B.11,CCL13,CXCL11.8,CXCL1,CXCL32B.1,CCL25,CCL28 |
| CCR chemokine receptor binding | CCL19A.2,CCL35.1,CCL25B,CCL20A.3,CCL18,CCL22,CCL34B.4,CCL15,CCL26,CCL21 |
| phospholipase activator activity | ARHGAP6,CCL5,APOC2,PDPK1,GM2A,CCL3 |
Interacting Protein
CCL8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL8 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL8.
Resources
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References
- Hayes, LN; Severance, EG; et al. Inflammatory Molecular Signature Associated With Infectious Agents in Psychosis. SCHIZOPHRENIA BULLETIN 40:963-972(2014).
- Ludlow, LE; Hasang, W; et al. Peripheral Blood Mononuclear Cells Derived from Grand Multigravidae Display a Distinct Cytokine Profile in Response to P. falciparum Infected Erythrocytes. PLOS ONE 9:-(2014).
