Recombinant Canine CCL8 protein

Cat.No. : CCL8-29C
Product Overview : Recombinant Canine CCL8 protein was expressed in E.coli.
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Description : MCP-2 and MCP-3 are two monocyte chemotactic proteins produced by human MG-63 osteosarcoma cells. Both MCP-2 and MCP-3 are members of the C-C family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP-1. MCP-3 also shares 58% amino acid identity with MCP-2. Similarly to other C-C chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.
Source : E.coli
Species : Canine
Form : Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH7.4.
Bio-activity : Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 10-100 ng/ml.
Molecular Mass : Approximately 8.8 kDa, a single non-glycosylated polypeptide chain containing 76 amino acids.
Protein length : 76
AA Sequence : QPDSVSIPITCCFSMVKRKIPMQKL ESYMRITNSQCPQEAVIFKTKASRE ICADPKQKWVQDYMNHLDQKSQAQK P
Endotoxin : Less than 0.1 EU/μg of rCaMCP-2/CCL8 as determined by LAL method.
Purity : >98% by SDS-PAGE and HPLC analyses.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : CCL8
Official Symbol : CCL8
Synonyms : MCP-2
Gene ID : 448792
mRNA Refseq : NM_001005255.1
Protein Refseq : NP_001005255.1
UniProt ID : Q68AY9

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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