Cd36

  • Official Full Name

    CD36 molecule (thrombospondin receptor)

  • Overview

    The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
  • Synonyms

    CD36; CD36 molecule (thrombospondin receptor); FAT; GP4; GP3B; GPIV; CHDS7; PASIV; SCARB3; BDPLT10; platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canine
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mesocricetus auratus (Golden hamster)
  • Monkey
  • Mouse
  • Rat
  • Rhesus Macaque
  • Rhesus monkey
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Avi
  • His
  • C
  • hFc
  • Fc
  • Flag
  • GST
  • His (Fc)
  • His|T7
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD36-22H Active Recombinant Human CD36 Protein, Fc-tagged Insect Cell Fc Gly30 - Asn439
Human CD36-2954H Active Recombinant Human CD36 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CD36-27868TH Recombinant Human CD36, His-tagged Wheat Germ His 472 amino acids
Human CD36-257H Recombinant Human CD36 protein, His-tagged Insect Cell His
Human CD36-0795H Recombinant Human CD36 Protein, GST-Tagged Wheat Germ GST
Human CD36-3184H Recombinant Human CD36 protein(Gly30-Asn439), His-tagged HEK293 C-His Gly30-Asn439
Human CD36-7084H Recombinant Human CD36 protein, His & T7-tagged E.coli His/T7 Leu187~Asn428 (Accession # P16671)
Human CD36-179H Recombinant Human CD36 protein, His-tagged HEK293 His Gly30-Asn439
Human CD36-0794H Recombinant Human CD36 Protein Wheat Germ N/A
Human CD36-2539HCL Recombinant Human CD36 cell lysate Human Cell N/A
Human CD36-1282H Recombinant Human CD36 protein, His-GST-tagged E.coli His Gly30~Asn439
Human CD36-074H Recombinant Human CD36 protein, His-Avi-tagged HEK293 His-Avi It contains Gly30-Asn439.
Human CD36-3084H Recombinant Human CD36 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD36-2828H Recombinant Human CD36 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD36-1957H Recombinant Human CD36 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD36-4963H Recombinant Human CD36 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD36-3163H Recombinant Human CD36 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD36-57HF Recombinant Full Length Human CD36 Protein, His-tagged In Vitro Cell Free System His 472 amino acids
Human CD36-39HFL Recombinant Full Length Human CD36 Protein, C-Flag-tagged Mammalian cells Flag
Human CD36-3169HF Recombinant Full Length Human CD36 Protein, GST-tagged In Vitro Cell Free System GST 472 amino acids
Human CD36-540H-B Recombinant Human CD36 Protein Pre-coupled Magnetic Beads HEK293
Human CD36-3166HF Recombinant Full Length Human CD36 Protein In Vitro Cell Free System 506 amino acids
Human CD36-0942H Recombinant Human CD36 Protein (Leu187-Asn428), N-His tagged E.coli N-His Leu187-Asn428
Human CD36-540H Recombinant Human CD36 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD36-153H Recombinant Human CD36 Protein, His-tagged HEK293 His 472
Human CD36-5346H Recombinant Human CD36 Protein (Gly30-Asn439), C-His tagged Mammalian cells C-His Gly30-Asn439
Human CD36-3077H Active Recombinant Human CD36 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Gly 30-Asn 439
Human CD36-5347H Recombinant Human CD36 Protein (Gln35-Asn439), C-His tagged Mammalian cells C-His Gln35-Asn439
Mouse Cd36-3323M Active Recombinant Mouse Cd36 protein, His-tagged HEK293 His Gly 30-Lys 439
Mouse Cd36-3322M Recombinant Mouse Cd36 protein(Gly30-Lys439), His&hFc-tagged HEK293 C-His&hFc Gly30-Lys439
Mouse Cd36-7085M Recombinant Mouse Cd36 protein, His & T7-tagged E.coli His/T7 Glu45~Pro203 (Accession # Q08857)
Mouse Cd36-365M Recombinant Mouse Cd36 Protein, His-tagged Insect Cell His
Mouse CD36-2400MCL Recombinant Mouse CD36 cell lysate Human Cell N/A
Mouse Cd36-834M Recombinant Mouse Cd36 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cd36-7170M Recombinant Mouse Cd36 Protein, His-tagged Insect Cell His 30-439
Mouse Cd36-3324M Recombinant Mouse Cd36(Gly30Lys439) Protein, C-Avi-6*His-tagged, Biotinylated HEK293 Avi-His
Rat Cd36-8751R Recombinant Rat Cd36 protein(Gly30-Lys439), hFc-tagged HEK293 C-hFc Gly30-Lys439
Rat Cd36-7086R Recombinant Rat Cd36 protein, His & T7-tagged E.coli His/T7 Tyr91~Cys311 (Accession # Q07969)
Rat CD36-1236RCL Recombinant Rat CD36 cell lysate Human Cell N/A
Rat Cd36-716R Recombinant Rat Cd36 protein, His-tagged HEK293 His Gly30-Lys439
Monkey CD36-001M Recombinant Monkey CD36 Protein HEK293
Rhesus monkey CD36-737R Recombinant Rhesus monkey CD36 Protein, Fc-tagged HEK293 Fc Gly30-Asn439
Bos taurus (Bovine) RFL32958BF Recombinant Full Length Bovine Platelet Glycoprotein 4(Cd36) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-472)
Canine CD36-3075C Recombinant Canine CD36 protein, His-tagged HEK293 His Gly 30-Asn 439
Cynomolgus CD36-96C Recombinant Cynomolgus CD36, Fc-tagged HEK293 Fc Gly30-Asn439
Cynomolgus CD36-3076C Recombinant Cynomolgus CD36 protein, His-tagged HEK293 His Gly 30-Asn 439
Cynomolgus Monkey CD36-1109CCL Recombinant Cynomolgus CD36 cell lysate Human Cell N/A
Homo sapiens (Human) RFL20295HF Recombinant Full Length Human Platelet Glycoprotein 4(Cd36) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-472)
Mesocricetus auratus (Golden hamster) RFL4071MF Recombinant Full Length Mesocricetus Auratus Platelet Glycoprotein 4(Cd36) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (2-472)
Rhesus Macaque CD36-736R Recombinant Rhesus monkey CD36 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD36-562R Recombinant Rhesus Macaque CD36 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CD36-562R-B Recombinant Rhesus Macaque CD36 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CD36-508Z Recombinant Zebrafish CD36 Mammalian Cell His
Chicken CD36-2432C Recombinant Chicken CD36 Mammalian Cell His
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
CD36 plays a role in tumor immunity.jpg

Fig1. CD36 plays a role in tumor immunity. (Xinzhi Liao, 2022)

What is CD36 protein?

CD36 (CD36 molecule) gene is a protein coding gene which situated on the long arm of chromosome 7 at locus 7q21. The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. The CD36 protein is consisted of 472 amino acids and its molecular mass is approximately 53.1 kDa.

What is the function of CD36 protein?

As a key receptor for fatty acid transmembrane transport, CD36 is involved in the uptake of long-chain fatty acids and is essential for maintaining energy balance and metabolic health. CD36 plays a role in regulating lipid metabolism, affecting the accumulation and breakdown of lipids within cells, and has been linked to the risk of obesity and cardiovascular disease. CD36 is involved in signaling during inflammation and promotes the release of inflammatory cytokines by binding ligands such as oxidized low density lipoprotein (oxLDL). As a cell surface molecule, CD36 is involved in intercellular adhesion and plays an important role in the migration and localization of immune cells. CD36 is also involved in iron transport, influencing iron metabolism and utilization by binding to heme. CD36 is involved in the regulation of energy balance by regulating the intake and utilization of fatty acids and is associated with the development of metabolic syndrome.

CD36 Related Signaling Pathway

As a co-receptor of TLR4, CD36 recognizes pathogen-related molecular patterns, activates NF-κB signaling pathway, and regulates natural immune processes. CD36 promotes thrombosis by activating REDOX sensitive signaling molecules, such as ERK5, and interacts with the ox-LDL/CRP/β2GP1 complex to activate the p38 MAPK/NF-κB signaling pathway, inducing lipid accumulation and inflammatory response in macrophages. Cd36-induced signaling cascades lead to activation of specific Src kinase and activation of FAK, promoting foam cell formation and expansion, influencing actin polymerization and macrophage migration. CD36 is related to mTOR signaling pathway, regulating energy metabolism and lipid accumulation. Liquid fructose supplement can activate mTOR signaling pathway and improve CD36 translation efficiency, causing lipid accumulation. CD36 is involved in Fyn/LKB1/AMPK pathway through LKB1 mediated phosphorylation of AMPK, and influences the uptake and oxidation of fatty acids.

CD36 Related Diseases

CD36 is involved in lipid metabolism, and its abnormal expression is associated with type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), atherosclerosis (AS), and obesity. CD36 plays a role in atherosclerosis and is associated with an increased risk of cardiovascular disease. CD36 is expressed in a variety of tumors, including breast, brain, and ovarian cancers, and its expression levels are associated with poor tumor progression and prognosis. CD36 is involved in the regulation of inflammatory responses and is associated with inflammatory diseases such as metabolic inflammatory syndrome (MIS). As a pattern recognition receptor, CD36 participates in natural immune processes and is associated with the occurrence and development of some infectious diseases. CD36 plays a role in age-related macular degeneration (AMD) and diabetic retinopathy (DR). CD36 may play a role in the development of chronic kidney disease by mediating lipid deposition and inflammatory responses in the kidneys.

Bioapplications of CD36

Because of its role in a variety of diseases, CD36 is an important research target, helping to shed light on the pathogenesis of metabolic diseases, cardiovascular diseases, tumors, and neurodegenerative diseases. As a potential target for drug development, CD36 is being investigated for the development of small molecule inhibitors and antibody drugs targeting this protein for the treatment of the above-mentioned related diseases.

High Purity

SDS PAGE (CD36-2954H).jpg

Fig1. SDS-PAGE (CD36-2954H)

High Bioactivity

Activity Data (CD36-2954H).jpg

Fig2. Activity Data (CD36-2954H)

Case Study 1: Shruti Gururaj Gadagkar, 2023

Innate immune response in neonatal brain is associated with a robust microglial activation and induction of Toll-like Receptors (TLRs). To date, the role of the scavenger receptor CD36 in TLRs modulation, particularly TLR2 signaling, has been well established in adult brain. However, the crosstalk between TLR4, TLR2 and CD36 and its immunogenic influence in the neonatal brain remains unclear. In this study, using a CD36 blocking antibody (anti-CD36) at post-natal day 8, the researchers evaluated the response of neonates to systemic endotoxin (lipopolysaccharide; LPS) challenge. They visualized the TLR2 response by bioluminescence imaging using the transgenic mouse model bearing the dual reporter system luciferase/green fluorescent protein under transcriptional control of a murine TLR2 promoter. The anti-CD36 treatment modified the LPS induced inflammatory profile in neonatal brains, causing a significant decrease in inflammatory cytokine levels and the TLR2 and TLR3 mediated signalling.The interferon regulatory factor 3 (IRF3) pathway remained unaffected. Treatment of the LPS-challenged human immature microglia with anti-CD36 induced a marked decrease in TLR2/TLR3 expression levels while TLR4 and IRF3 expression was not affected, suggesting the shared CD36 regulatory mechanisms in human and mouse microglia.

Quantification of the in vivo bioluminescence data from P8–P12.jpg

Fig1. Quantification of the in vivo bioluminescence data from P8–P12 (in photons per second, p/s).

CXCL13 when the pups are treated with anti-CD36 before LPS.jpg

Fig2. CXCL13 when the pups are treated with anti-CD36 before LPS.

Case Study 2: Jun Zhang, 2022

This study aimed to elucidate the roles of miR-1254 in cervical cancer progression and to explore the underlying mechanisms. The binding sites between CD36 and miR-1254 were determined using luciferase reporter assays. The correlation of CD36 and miR-1254 with cervical cancer development was re-confirmed by co-transfection of miR-1254 mimic and CD36 overexpression using CCK-8, colony formation, transwell and western blot assays. The luciferase reporter assays demonstrated that CD36 messenger RNA and miR-1254 bound to one another. CD36 overexpression reversed the inhibitory effects of upregulated miR-1254 in the cervical cancer cells, suggesting that miR-1254 regulates cervical cancer progression by modulating CD36.

CD36 overexpression rescued the effects of miR-1254 on the cervical cancer cells.jpg

Fig3. CD36 overexpression rescued the effects of miR-1254 on the cervical cancer cells.

The transwell assays showed that CD36 overexpression enhanced the invasive ability of the SiHa cells transfected with miR-1254 mimic.jpg

Fig4. The transwell assays showed that CD36 overexpression enhanced the invasive ability of the SiHa cells transfected with miR-1254 mimic.

Cd36 involved in several pathways and played different roles in them. We selected most pathways Cd36 participated on our site, such as PPAR signaling pathway, Phagosome, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cd36 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayACSL1B;APOA2;ADIPOQ;LPL;ACSL4B;FABP1A;ACSBG1;CYP7A1A;FABP1
PhagosomeHLA-A;FAM49BA;ATP6V0C;TUBB1;TLR2;CD36;THBS4B;TUBA8L3;TUBA1L2
AMPK signaling pathwayTSC2;ELAVL1;CCNA1;PIK3CD;FBP2;PRKAB1;PPP2R1A;PIK3CB;PPP2R2B
ECM-receptor interactionCOL1A1A;FN1;THBS2;DAG1;COL6A1;GP6;LAMB1A;TNR;FN1A
Hematopoietic cell lineageCD14;CSF3;ITGB3;EPOR;ITGA1;ITGA4;CSF1R;ITGA6;GP5
Adipocytokine signaling pathwaySLC2A4;G6PC;SLC2A1;ACSL4;PTPN11B;NFKBIA;PCK2;PPARA;PRKAA1
Insulin resistancePRKCBB;TBC1D4;RPS6KA3;INSRA;PIK3R3B;PPP2R4;PRKAG2A;INS;INSRB
Fat digestion and absorptionCD36;FABP2;MOGAT3;LIPF;APOB;PLA2G12B;MOGAT2;FABP1;AGPAT2
MalariaHBB;KLRC4-KLRK1;GYPA;HBA1;IL-8;CD40LG;VCAM1;CD81;CD40

Cd36 has several biochemical functions, for example, MAP-kinase scaffold activity, kinesin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Cd36 itself. We selected most functions Cd36 had, and list some proteins which have the same functions with Cd36. You can find most of the proteins on our site.

Function Related Protein
MAP-kinase scaffold activityCD36;DUSP19;MAPK8IP2;JIP1;SPAG9A;KSR1;SPAG9;MAPK8IP3
kinesin bindingJAKMIP1;DISC1;PLEKHM2;MAPK8IP3;KIF18B;KLC3;ATCAY;SYBU;TOR1A
protein bindingZFP36;BNIP1;EVC2;NAB2;KLF4;MPZL2B;CTGF;SOCS1;ALS2
protein kinase bindingCCNL1A;CADPS;MAPK8IP2;RPTOR;MAP3K1;CSPG4;SLC12A4;SPAG16;PRKAB1
protein kinase inhibitor activitySOCS3B;SOCS1B;GMFG;CD36;SOCS1;DUSP19;SOCS3A;CAMK2N1A;MBIP

Cd36 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cd36 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cd36.

dacD; cutA; q7ciq1_yerpe; yapE; icc; CHRD; cona_canen

Research Area

Related articles

Puig, KL; Manocha, GD; et al. Amyloid Precursor Protein Mediated Changes in Intestinal Epithelial Phenotype In Vitro. PLOS ONE 10:-(2015).
He, L; Zhou, XM; et al. Comparative Study of the Growth and Survival of Recombinant Mycobacterium smegmatis Expressing Mce4A and Mce4E from Mycobacterium bovis. DNA AND CELL BIOLOGY 34:125-132(2015).
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Q&As (7)

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What is the impact of CD36 on inflammation and the immune response, particularly in chronic inflammatory diseases? 01/23/2022

CD36 is involved in inflammation and immune responses, potentially exacerbating chronic inflammatory conditions.

How do alterations in CD36 expression or activity affect obesity and related health complications? 07/08/2021

Variations in CD36 function can influence the risk of obesity and associated health issues like metabolic syndrome.

What are the mechanisms by which CD36 modulates cell signaling and energy homeostasis? 03/15/2021

CD36 modulates cell signaling related to energy utilization and storage, impacting metabolic health.

How does CD36 contribute to the pathogenesis of metabolic disorders, such as insulin resistance and type 2 diabetes? 03/01/2021

CD36 affects the development of metabolic disorders by influencing lipid metabolism and insulin sensitivity.

How does CD36 influence taste perception, especially in the detection of dietary fats? 06/27/2020

CD36 aids in taste perception, particularly in detecting and responding to dietary fats.

What role does CD36 play in the development of cardiovascular diseases like atherosclerosis? 02/09/2020

CD36 is implicated in cardiovascular diseases, contributing to the formation of atherosclerotic plaques.

How does CD36 (Cluster of Differentiation 36) function in fatty acid metabolism and uptake? 08/27/2019

CD36 facilitates the uptake and metabolism of fatty acids in cells, playing a critical role in lipid processing.

Customer Reviews (3)

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Reviews
05/21/2020

    Dependable protein purification, consistently high-quality results.

    04/10/2019

      Great antibody validation, enhances our immunoprecipitation experiments.

      12/28/2018

        Swift protein expression optimization, invaluable for our research efficiency.

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